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| 1 | Dating the endometrial biopsy显示文摘 | NOYES R W HERTIG A T ROCK J | 1975 | Am J Obstet Gynecol1975，122，2： | 1 |
| 2 | Cytogenetic findings in pituitary adenoma: results of a pilot study 显示文摘 | Babu R Drumheller T | 1993 | Surg Neurol1993，41，： | 1 |
| 3 | Proteomic analysis reveals changes in the liver protein pattern of rats exposed to dietary folate deficiency显示文摘 | Chanson A Sayd T Rock E | 2005 | J Nutr2005，135，： | 1 |
| 4 | Commonage Land and Farmer Up- take of the Rural Environment Protection Scheme in Ireland 显示文摘 | Van Rensburg T M Murphy E Rocks P | 2009 | Land Use Policy2009，26，2： | 1 |
| 5 | Women at altitude:energy requirement at 4,300 m显示文摘 | MAWSON J T BRAUN B ROCK P B | 2000 | J Appl Physiol2000，88，1： | 1 |
| 6 | Comparison of in Situ and Airborne Spectral Measurements of the Blue Shift Associated with Forest Decline显示文摘 | Rock B N Hoshizaki T Miller J R | 1988 | Remote Sensing of Environment1988，24，： | 1 |
| 7 | Trends in mortality from coronary heart and cerebrovascular diseases in the Americas: 1970-2000显示文摘 | Rock iguez T Malvezzi M Chatenoud L | 2006 | Heart2006，92，4： | 1 |
| 8 | Comparison of in situ and airbome spectral measurements of the blue shift associated with forest decline显示文摘 | Rock B N Hoshizaki T Miller J R | | 0，，01： | 1 |
| 9 | Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism显示文摘We have recently developed an enzyme-directed immunostimulant(EDI)prodrug motif,which is metabolized to active immunostimulant by cancer cells and,following drug efflux,activates nearby immune cells,resulting in immunogenicity.In this study,we synthesized several EDI prodrugs featuring an imidazoquinoline immunostimulant resiquimod(a Toll-like receptor 7/8 agonist)covalently modified with glycosidase enzyme-directing groups selected from substrates of β-glucuronidase,α-mannosidase,or β-galactosidase.We compared the glycosidase-dependent immunogenicity elicited by each EDI in RAW-Blue macrophages following conversion to active immunostimulant by complementary glycosidase.At a cellular level,we examined EDI metabolism across three cancer cell lines(B16 melanoma,TC2 prostate,and 4T1 breast cancer).Comparing the relative immunogenicity elicited by each EDI/cancer cell combination,we found that B16 cells produced the highest EDI prodrug immunogenicity,achieving>95% of that elicited by unmodified resiquimod,followed by TC2 and 4T1 cells(40% and 30%,respectively).Immunogenicity elicited was comparable for a given cell type and independent of the glycosidase substrate in the EDIs or differences in functional glycosidase activity between cell lines.Measuring drug efflux of the immunostimulant payload and efflux protein expression revealed that EDI/cancer cell-mediated immunogenicity was governed by efflux potential of the cancer cells.We determined that,following EDI conversion,immunostimulant efflux occurred through both P-glycoprotein-dependent and P-glycoprotein-independent transport mechanisms.Overall,this study highlights the broad ability of EDIs to couple immunogenicity to the metabolism of many cancers that exhibit drug efflux and suggests that designing future generations of EDIs with immunostimulant payloads that are optimized for drug efflux could be particularly beneficial. | Austin T Ryan Anunay J Pulukuri Maryam Davaritouchaee Armina Abbasi Aaron T Hendricksen Larissa K Opp Anthony J Burt Amy E Nielsen Rock J Mancini | 2020 | Acta Pharmacologica Sinica2020，41，7： | 1 |
| 10 | Protein degradation and the generation of MHC class I-presented peptides显示文摘 | Rock K L York I A Saric T | 2002 | Adv Immunol2002，80，： | 1 |
| 11 | Colony-stimulating factor 1 regulates CTP:phosphocholine cytidylyltransferase mRNA levels显示文摘 | Tessner T G Rock C O Kalmar G B | 1991 | J Biol Chem1991，266，16： | 1 |
| 12 | Nutrition and Physical Activity Guidelines for Cancer Survivors显示文摘 | Rock CL Doyle C Gansler T | 2012 | CA CANCER J CLIN2012，62，4： | 1 |
| 13 | Development and experimental valida- tion of an underwater manipulator hydrodynamic model 显示文摘 | McLain T W Rock S M | 1998 | The International Journal of Robotics Research1998，17，7： | 1 |
| 14 | The Comparative Politics ot torrup- tion: Accounting for the East Asian Paradox in Empirical Studies of Corruption, growth and investment 显示文摘 | Rock M T H Bonnett | 2004 | World Development2004，32，6： | 1 |
| 15 | Space environment effects on damaping of polymer matrix carbon fiber composites显示文摘 | Strganac T W Letton A Rock N I | 2000 | Journal of Spacecraft and Rockets2000，37，4： | 1 |
| 16 | Detection of latent pseudorabies virus in swine using in si tu hybridization 显示文摘 | Brown T M Osorio F A Rock D L | 1990 | Vet Microbiol1990，24，： | 1 |
| 17 | Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory ( FOXP3 )/effector ( CIM, CDS) T cell ratios显示文摘 | WeitkampJH Koyama T Rock MT | 2013 | Gut2013，62，1： | 1 |
| 18 | Detection of tibial condylar fractures using 3D imaging with a mobile image amplifier (Siemens ISO-C-3D):Comparison with plain films and spiral CT显示文摘 | Kotsianos D Rock C Wirth S Linsenmaier U Brandl R Fischer T Euler E Mutschler W Pfeifer KJ Reiser M | 2002 | Rofo2002，174，： | 1 |
| 19 | Commonage land and farmer uptake of the rural environment protection scheme in Ireland 显示文摘 | Van Rensburg T M Murphy E Rocks P | 2009 | Land Use Policy2009，26，2： | 1 |
| 20 | Detection of latent PRV in swine in situ hybridization显示文摘 | Brown T M Osorio F A Rock D L | 1990 | Vet Microbiol1990，，24： | 1 |
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