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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Neural mechanisms involved in the delay of gastric emptying and gastrointestinal transit of liquid after thoracic spinal cord transection in awake rats 显示文摘 | Gondim F A Rodrigues C L da-Graca J R | 2001 | Auton Neurosci2001，87，1： | 1 |
| 3 | Normal human monocytes exposed to glioma cells acquire myeloid-derived suppressor cell-like properties显示文摘 | RODRIGUES J C GONZALEZ G C ZHANG L | 2010 | Neuro Oncol2010，12，4： | 1 |
| 4 | Spatial and temporal variation of phytoplankton in two subtropical Brazilian reservoirs 显示文摘 | BORGES P A F TRAIN S RODRIGUES L C | 2008 | Hydrobiologia2008，607，： | 1 |
| 5 | Novel core (polyester)-shell (polysaccharide) nanoparticles :protein loading and surface modification with leetins显示文摘 | Rodrigues J S Santos-Magalhaes N S Coelho L C B B | 2003 | Journal of Controlled Release2003，92，： | 1 |
| 6 | Novel core (polyester) -shell (polysaccharide) nanoparticles:protein loading and surface modification with lectins显示文摘 | Rodrigues J S Santos-Magalhes N S Coelho L C B B | 2003 | J Controlled Release2003，92，12： | 1 |
| 7 | Pollution source evaluation using petroleum and aliphatic hydrocarbons in surface sediments from two Brazilian estuarine systems显示文摘 | Maioli O L G Rodrigues K C Knoppers B A | | 0，，09： | 1 |
| 8 | Acclima- tion of Myrtus communis to contrasting Mediterranean light environments effects on structure and chemical composition of foliage and plant water relations 显示文摘 | Mendes M M Gazarini L C Rodrigues M L | 2001 | En- vironmental and Experimental Botany2001，45，2： | 1 |
| 9 | Physiological effects of copper in the euryhaline copepod Acartia tonso:Waterborne versus watarborne plus dietborne exposure显示文摘 | Pinho G L Pedroso M S Rodrigues S C | | 0，，01： | 1 |
| 10 | Physieochemical and functional characterization of a biosurfactant produced by lactococcus lactic 53显示文摘 | Rodrigues L R Teixeira J A Vander Mei H C | 2006 | Colloids and surfaces B2006，49，1： | 1 |
| 11 | Effects of Deficit Irrigation Strategies on Cluster Microclimate for Improving Fruit Composition of Moscatel field-grown Grapevines显示文摘 | Dos Santos T P Lopes C M Rodrigues M L | 2007 | Scientia Horticuhurae2007，112，3： | 1 |
| 12 | Antioxidant principles and volatile constituents from the north-western iberian mint 'erva-peixeira',mentha cervina显示文摘 | Politi M Rodrigues C L Giao M S | | 0，，12： | 1 |
| 13 | NO~ storage on barium-contai- ning three-way catalyst in the presence of CO2 显示文摘 | Rodrigues F Juste L Potvin C | 2001 | Catalysis Let- ters2001，72，12： | 1 |
| 14 | On rational recursive sequences显示文摘 | Kocic V L Ladas C Rodrigues I W | 1993 | J Math Anal Appl1993，172，： | 1 |
| 15 | Response surface methodology for xylitol production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables显示文摘 | Rodrigues R C L B das Gracis A Felipc M | 2003 | Process Biochemistry2003，38，： | 1 |
| 16 | Haematological and biochemical characteristics of male jundi(Rhamdia quelen Quoy & Gaimard Pimelodidae):changesafter acute stress显示文摘 | BARCELLOS L J G KREUTZ L C RODRIGUES L B | 2003 | Aquacult Res2003，34，15： | 1 |
| 17 | Death receptors and mitochondria: Two prime triggers of neural apoptosis and dif- ferentiation显示文摘 | Sold S Morgado A L Rodrigues C M P | 2013 | Biochimicaet Biophysica Aeta (BBA) GeneralSubjects2013，1830，1： | 1 |
| 18 | Prevalence of caries and associated factors in hemophiliac children 显示文摘 | Rodrigues M J Luna A C A Lea1 L C | 2008 | Hemoterapia2008，30，： | 1 |
| 19 | Evalu- ation of the knowledge of health professionals at a pediatric hospital regarding the use of metered - dose inhalers 显示文摘 | Muchao F P Perin S L R R Rodrigues J C | 2008 | Jornal Brasileiro de Pneumologia2008，34，1： | 1 |
| 20 | Optimizing dissolved air flotation design and saturation显示文摘 | Feris L A Gallina C W Rodrigues R T | 2001 | Water Science and Technology2001，43，8： | 1 |
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