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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry 显示文摘 | Giuffrida A Rodriguez de Fonseca F Piomelli D | 2000 | Anal Biochem2000，280，1： | 1 |
| 3 | Structural integrity of hot strip mill rolling rolls显示文摘 | Belzunce F J Ziadi A Rodriguez C | 2004 | Engineering Failure Analysis2004，11，78： | 1 |
| 4 | Characteristics of the heterotrophic population in hypersaline environments of different salt concentration显示文摘 | RODRIGUEZ V F RUIZ B F RAMOS C A | 1981 | Microbiol Ecol1981，7，： | 1 |
| 5 | Mice cloned from embryonic stem cell显示文摘 | Wakayama T Rodriguez I Perry A C F | 1999 | Proc Natl Acad Sci USA1999，，14： | 1 |
| 6 | Retinoid-dependent mRNA expression and poly-(A) contents in bovine oocytes meiotically arrested and/or matured in vitro 显示文摘 | Gomez E Rodriguez A Goyaehe F | 2004 | Mol Reprod Dve2004，69，： | 1 |
| 7 | Physical characterization of hydroxyapatite porous scaffolds for tissue engineering 显示文摘 | Teixeira S Rodriguez M A Pena P De Aza A H De Aza S Ferraz M P Monteiro F J | 2009 | Materials Science & Engineering C-Biomimetic and Supramolecular Systems2009，29，5： | 1 |
| 8 | Simplified modeling of a DFIG for transient studies in wind power applica- tions显示文摘 | LUNA A LIMA F K RODRIGUEZ D SANTOS P | 2011 | IEEE Transactions on Industrial Electronics2011，58，1： | 1 |
| 9 | Rotor voltage dynamics in the doubly fed induction generator during grid faults显示文摘 | Lima F K Luna A Rodriguez P A | 2010 | IEEE Transactions on Power Electronics2010，25，1： | 1 |
| 10 | Genetic manipulation of lignin reduces recalcitrance and improves ethanol production from switchgrass 显示文摘 | Fu C Mielenz JR Xiao X Ge Y hamilton CY Rodriguez M Chen F Foston M Ragauskas A Bouton J Dixon RA Wang ZY | 2011 | Proc Natl Acad Sci USA2011，108，9： | 1 |
| 11 | Management of spermatic cord tumors: a rare urologic malignancy显示文摘 | Rodriguez D Olumi A F | 2012 | Ther AdvUrol2012，4，6： | 1 |
| 12 | Carbon nanotubes provide self extinguishing grade to silicone-based foams显示文摘 | VERI)EJO R BARROS()-BUJANS F RODRIGUEZ PEREZ M A | 2008 | Journal of Materials Chemistry2008，18，33： | 1 |
| 13 | Incidentally detected renal cell carcinoma 显示文摘 | RODRIGUEZ RUBIO FI DIEZ CABALLERO F MARTIN MARGUINA A | 1996 | Br J Urol1996，78，： | 1 |
| 14 | 显示文摘 | Medina F Rodriguez X | 2001 | Applied Catalysis B:Environmental2001，30，： | 1 |
| 15 | Cu/Ni/AI layereddouble hydroxides as Precursors of catalysts for the wet air oxidation of phenol aqueous solutions 显示文摘 | Alejandre A Medina F Rodriguez X | 2001 | Applied Catalysis Environmental2001，30，： | 1 |
| 16 | Rotor voltage dynamic in the doubly fed induction generator during grid faults 显示文摘 | Lima F K A Luna A Rodriguez P | 2010 | IEEE Trans on Power Electronics2010，25，1： | 1 |
| 17 | Characterization and molecular basis of heterogeneity of the African swine fever vi- rus envelope protein p54 显示文摘 | Rodriguez F Alcaraz C Eiras A | 1994 | J Virol1994，68，11： | 1 |
| 18 | Activated carbons form sewage sludge:Application to aqueousphase adsorption of 4-chlorophenol显示文摘 | Monsalvo V M Mohedano A F Rodriguez J J | 2011 | Desalination2011，277，123： | 1 |
| 19 | Alterations in left ventricular torsion and diastolic recoil after myocardial infarction with and without chronic ischemic mitral regurgitation显示文摘 | TIBAYAN F A RODRIGUEZ F LANGER F | 2004 | Circulation2004，110，11： | 1 |
| 20 | mi- eroRNA 30c expression lvel is an independent predictor of clinical benefit o{ endocrine therapy in advanced estrogen re- ceptor positive breast cancer显示文摘 | Rodriguez Gonzalez F G Sieuwerts A M Smlcl M | 2011 | Breast Cancer Res Treat2011，127，1： | 1 |
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