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| 1 | Depletion of Beelin-1 due to proteolytic cleavage by easpases in the Alzheimer' s disease brain 显示文摘 | Rohn TI' Wirawan E Brown R J | 2011 | Neurobiol Dis2011，43，1： | 1 |
| 2 | Apoptin induces tumor-specific apoptosis as a globular multimer显示文摘 | Leliveld S R Zhang Y J Rohn J L | 2003 | J Biol Chem2003，278，11： | 1 |
| 3 | Apoptin induces tumor-specific apoptosis as a random,globular multimer显示文摘 | Zhang Y H Rohn J L | 2003 | J Biol Chem2003，278，11： | 1 |
| 4 | A tumor-specific kinase activity regulates the viral death protein apoptin显示文摘 | Zhang Y H Aralbers R I | 2002 | J Biol Chem2002，277，50： | 1 |
| 5 | Polyamine Metabolism in Brain Tumors:Diagnostic Relevance of Quantitative Biochemistry显示文摘 | ERNESTUS RI ROHN G SCHRODER R | 2001 | J Neurol Neurosurg Psychiatry(S0022-3050)2001，71，： | 1 |
| 6 | Polyamine metabolism in brain tumours: diagnostic relevance of quantitative biochemistry 显示文摘 | Ernestus RI Rohn G Schroder R | 2001 | J-Neurol-Neurosurg-Psychiatry2001，71，1： | 1 |
| 7 | Non-secreted clusterin iso- forms are translated in rare amounts from distinct human mRNA vari- ants and do not affect Bax-mediated apoptosis or the NF-KB signaling pathway 显示文摘 | Prochnow H Gollan R Rohne P ct al | 2013 | PLoS One2013，8，75： | 1 |
| 8 | Depletion of Beclin - 1 due to proteolytic cleavage by caspases in the Alzheimers dis- ease brain 显示文摘 | Rohn T T Wirawan E Brown R J | 2011 | Neurobiol Dis2011，43，1： | 1 |
| 9 | A tumor specific kinase activity regulates the viral death protein apoptin显示文摘 | Rohn J Zhang Y H Aalbers R I | 2002 | Biol Chem2002，277，50： | 1 |
| 10 | Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain 显示文摘 | ROHN :1' 1' RISSMAN R A DAVIS M C | 2002 | Neurobiol Dis2002，15，： | 1 |
| 11 | Apoptin induces tumor-specific apoptosis as a globular multimer显示文摘 | Leliveld S R Zhang Y H Rohn J L | 2003 | Biol Chem2003，278，11： | 1 |
| 12 | Apoptin's functional N-and C-termini independently bindDNA显示文摘 | Leliveld S R Dame R T Rohn J L | 2004 | FEBS Lett2004，557，13： | 1 |
| 13 | A Multipathogen Bile Sample-based PCR Assay Can Guide Empirical Antimicrobial Strategies in Cholestatic Liver Diseases显示文摘Background and objectives:Polymerase chain reaction(PCR)techniques provide rapid detection of pathogens.This pilot study evaluated the diagnostic utility and clinical impact of multiplex real-time PCR(mRT-PCR,SeptiFast)vs.conventional microbial culture(CMC)in bile samples of patients with chronic cholestatic liver diseases(cCLDs),endoscopic retrograde cholangio-pancreatography(ERCP),and peri-interventional-antimicrobial-prophylaxis(pAP).Methods:We prospectively collected bile samples from 26 patients for microbiological analysis by CMC and mRT-PCR.Concordance of the results of both methods was determined by Krippendorff's alpha(α)for inter-rater reliability and the Jaccard index of similarity.Results:mRT-PCR_(bile)and CMC_(bile)results were concordant for only Candida albicans(α=0.8406;Jaccard index=0.8181).mRT-PCR_(bile)detected pathogens in 8/8 cases(100%),CMC_(bile)in 7/8(87.5%),and CMCblood in 5/8(62.5%)with clinical signs of infection.mRTPCR_(bile),CMC_(bile),and CMCblood had identical detection results in 3/8(37.5%)with clinical signs of infection(two Klebsiella spp.and one Enterococcus faecium).The total pathogen count was significantly higher with mRT-PCR_(bile)than with CMC_(bile)(62 vs.31;χ^(2)=30.031,p<0.001).However,pathogens detected by mRT-PCR_(bile)were more often susceptible to pAP according to the patient infection/colonization history(PI/CH)and surveillance data for antibiotic resistance in our clinic(DARC).Pathogens identified by mRT-PC_(Rbile)and resistant to pAP by PI/CH and DARC were likely to be clinically relevant.Conclusions:mRT-PCR in conjunction with CMCs for bile analysis increased diagnostic sensitivity and may benefit infection management in patients with cholestatic diseases.Implementation of mRT-PCR in a bile sample-based diagnostic routine can support more rapid and targeted use of antimicrobial agents in cCLD-patients undergoing ERCP and reduce the rate/length of unnecessary administration of broad-spectrum antibiotics. | Michael Jahn Mustafa KÖzçürümez Sebastian Dolff Hana Rohn Dominik Heider Alexander Dechêne Ali Canbay Peter M.Rath Antonios Katsounas | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 14 | Metabolic differences between primary and recurrent human brain tumors: a ^1H NMR spectroscopic investigation显示文摘 | Lehnhardt F G Boek C Rohn G Ernestus R I Hoehn M | 2005 | NMR Biomed2005，18，： | 1 |
| 15 | Impact ofa new cloud motion wind product from Meteosat onNWP analyses and forecasts 显示文摘 | ROHN M KELLY G SAUNDERS R W | 2001 | Mon Wea Rev2001，，129： | 1 |
| 16 | A tumor-specific kinase activity regulates the viral death protein apoptin显示文摘 | Rohn J L Zhang Y H Aalbers R l | 2002 | Biol Chem2002，277，50： | 1 |
| 17 | Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis显示文摘 | Danen-Van Oorschot A A Zhang Y H Leliveld S R Rohn J L Seelen M C Bolk M W Van Zon A Erkeland S J Abrahams J P Mumberg D Noteborn M H | 2003 | J Biol Chem2003，278，27： | 1 |
| 18 | Apoptin protein multimers form distinct higher-order nucleoprotein complexes with DNA显示文摘 | Leliveld S R Dame R T Mommaas M A Koerten H K Wyman C Danen-van Oorschot A A Rohn J L Noteborn M H Abrahams J P | 2003 | Nucleic Acids Res2003，31，16： | 1 |
| 19 | Ganglioside profiles in human gliomas:quantifioation by microbore high performance liquid chromatography and correlation to histomorphology and grading显示文摘 | Wagener R Rohn G | 1999 | Acta Neurochir Wien1999，141，12： | 1 |
| 20 | Ganglioside profiles in human gliomas : quantifioation by microbore high performance liquid chromatography and correlation to histomorphology and grading显示文摘 | Wagener R Rohn G | 1999 | Acta Neurochir Wien1999，141，12： | 1 |
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