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| 1 | Characterization of functional biliary pain and dyspeptic symptoms in patients with sphincter of Oddi dysfunction:Effect of papillotomy显示文摘AIM: To characterize functional biliary pain and other gastrointestinal (GI) symptoms in postcholecystectomy syndrome (PCS) patients with and without sphincter of Oddi dysfunction (SOD) proved by endoscopic sphincter of Oddi manometry (ESOM), and to assess the post- endoscopic sphincterotomy (EST) outcome. METHODS: We prospectively investigated 85 cholecystectomized patients referred for ERCP because of PCS and suspected SOD. On admission, all patients completed our questionnaire. Physical examination, laboratory tests, abdominal ultrasound, quantitative hepatobiliary scintigraphy (QHBS), and ERCP were performed in all patients. Based on clinical and ERCP findings 15 patients had unexpected bile duct stone disease and 15 patients had SOD biliary typeⅠ. ESOM demonstrated an elevated basal pressure in 25 patients with SOD biliary-type Ⅲ. In the remaining 30 cholecystectomized patients without SOD, the liver function tests, ERCP, QHBS and ESOM were all normal. As a control group, 30 ‘asymptomatic’ cholecystectomized volunteers (attended to our hospital for general cardiovascular screening) completed our questionnaire, which is consisted of 50 separate questions on GI symptoms and abdominal pain characteristics. Severity of the abdominal pain (frequency and intensity) was assessed with a visual analogue scale (VAS). In 40 of 80 patients having definite SOD (i.e. patients with SOD biliary typeⅠand those with elevated SO basal pressure on ESOM), an EST was performed just after ERCP. In these patients repeated questionnaires were filled at each follow-up visit (at 3 and 6 mo) and a second lookQHBS was performed 3 mo after the EST to assess the functional response to EST. RESULTS: The analysis of characteristics of the abdominal pain demonstrated that patients with common bile duct stone and definite SOD had a significantly higher score of symptomatic agreement with previously determined biliary-like pain features than patient groups of PCS without SOD and controls. In contrary, no significant differences were found when the pain severity scores were compared in different groups of PCS patients. In patients with definite SOD, EST induced a significant acceleration of the transpapillary bile flow; and based on the comparison of VASs obtained from the pre- and post-EST questionnaires, the severity scores of abdominal pain were significantly improved, however, only 15 of 35 (43%) patients became completely pain free. Post-EST severity of abdominal pain by VASs was significantly higher in patients with predominant dyspepsia at initial presentation as compared to those without dyspeptic symptoms. CONCLUSION: Persistent GI symptoms and general patient dissatisfaction is a rather common finding after EST in patients with SOD, and correlated with the presence of predominant dyspeptic symptoms at the initial presentation, but does not depend on the technical and functional success of EST. | László Madácsy Roland Fejes Gábor Kurucsai Ildikó Joó András Székely Viktória Bertalan Attila Szepes János Lonovics | 2006 | World Journal of Gastroenterology2006，12，42： | 33 |
| 2 | ICAM-1 expression deter- mines malignant potential of cancer 显示文摘 | Roland C L Harken A H Sarr M G | 2007 | Surgery2007，141，6： | 1 |
| 3 | Boundary and elastohydrodynamic lubrication studies of glycerol aqueous solutions as green lubricants 显示文摘 | Mattias G Marcus B Roland L | 2014 | Tribology International2014，69，： | 1 |
| 4 | Systematic characterization of oil in water emulsions for formulation design显示文摘 | Roland I Piel G Delattre L | 2003 | International Journal of Pharmaceuties2003，263，12： | 1 |
| 5 | The application of the energy landscape model to polymers显示文摘 | Roland C M Santangelo P G Ngai K L | | 0，，： | 1 |
| 6 | Confined placental mosaicism in CVS and pregnancy outcome显示文摘 | Roland B Lynch L Berkowitz G | 1994 | Prenat Diagn1994，14，： | 1 |
| 7 | Effects of labor on pla- cental expression of superoxide dismutases in preeelampsia 显示文摘 | Roland L Beauchemin D Acteau G | 2010 | Placenta2010，31，5： | 1 |
| 8 | Systematic Characterization of Oil- in -water Emulsions for Formulation Design 显示文摘 | Roland I Piel G Delattre L | 2003 | Int J Phann2003，263，12： | 1 |
| 9 | Analysis of tetraploid elymus species using wheat microsatellite markers and RAPDmarkers显示文摘 | SUN G L BJOM S ROLAND V B | 1998 | Genome1998，40，： | 1 |
| 10 | Comparison of dynamic headspace and simultaneous distillation extraction techniques used for the analysis of the volatile components in three European PDO ewes'milk cheeses 显示文摘 | Patricia L Margherita A Roland G | 2001 | Interna- tional Dairy Journal2001，11，： | 1 |
| 11 | Reform without Losers: An Interpretation of China's Dual-Track Approach to Transition 显示文摘 | LAU L J QIAN Y Y ROLAND G | 2000 | Journal of Political Economy2000，108，1： | 1 |
| 12 | Ocular manifestations associ- ated with brucellosis: a 26-year experience in Peru显示文摘 | Roland I Olarte L Vilchez G | 2008 | Clin Infect Dis2008，46，9： | 1 |
| 13 | Structure,functionand expression of voltage-dependent sodium channels显示文摘 | Roland G Sidney A C Robert L B | 1993 | Mol Neurobiol1993，7，： | 1 |
| 14 | Systemic characterization of oil-in-water emulsions for formulation design显示文摘 | Roland I Piel G Delattre L | | 0，，： | 1 |
| 15 | Effects of labor onplacental express ion of superoxide dismutases in preeclampsia 显示文摘 | Roland L Beauchemin D Acteau G | 2010 | Placenta2010，31，5： | 1 |
| 16 | Molecular characterization of fervidolysin, a subtilisin-like serine protease from the thermophilic bacterium Fervidobacterium pennivorans 显示文摘 | Kluskens L D Wilfried G V Roland J | 2002 | Extremophiles2002，，6： | 1 |
| 17 | Functional analysis of three plasmids from Lactobacillus plantarum 显示文摘 | Richard V K Natasa G Roger B Rob J L Willem M D V Roland J S and Michiel K | 2005 | Applied and Environmental Microbiology2005，3，： | 1 |
| 18 | Column abun- dance and the long-term trend of hydrogen chloride ( HCI ) above the Jungfraujoch station显示文摘 | Zander R Roland G Delbouille L | 1987 | Journal of At-mospheric Chemistry1987，5，4： | 1 |
| 19 | The consequences of issuing convertible bonds: Dilution and / or financial restricting? 显示文摘 | Roland G Hubert L B | 2010 | European Financial Management2010，16，55： | 1 |
| 20 | Reform without losers: an interpretation of Chirna's dual track approach to transition显示文摘 | LAO L J QIAN Y G ROLAND | 2000 | J Political Economy2000，108，1： | 1 |
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