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| 1 | Noninvasive methods for prediction of esophageal varices in pediatric patients with portal hypertension显示文摘AIM: To evaluate clinical and laboratory parameters for prediction of bleeding from esophageal varices (EV) in children with portal hypertension. METHODS: Retrospective study of 103 children (mean age: 10.1 ± 7.7 years), 95.1% with intrahepatic portal hypertension. All patients had no history of bleeding and underwent esophagogastroduodenoscopy for EV screening. We recorded variceal size (F1, F2 and F3), red-color signs and portal gastropathy, according to the Japanese Research Society for Portal Hypertension classification. Patients were classified into two groups: with and without EV. Seven noninvasive markers were evaluated as potential predictors of EV: (1) platelet count; (2) spleen size z score, expressed as a standard deviation score relative to normal values for age; (3)platelet count to spleen size z score ratio; (4) platelets count to spleen size (cm) ratio; (5) the clinical prediction rule (CPR); (6) the aspartate aminotransferase to platelet ratio index (APRI); and (7) the risk score. RESULTS: Seventy-one children had EV on first endoscopy. On univariate analysis, spleen size, platelets, CPR, risk score, APRI, and platelet count to spleen size z score ratio showed significant associations. The best noninvasive predictors of EV were platelet count [area under the receiver operating characteristic curve (AUROC) 0.82; 95%CI: 0.73-0.91], platelet: spleen size z score (AUROC 0.78; 95%CI: 0.67-0.88), CPR (AUROC 0.77; 95%CI: 0.64-0.89), and risk score (AUROC 0.77; 95%CI: 0.66-0.88). A logistic regression model was applied with EV as the dependent variable and corrected by albumin, bilirubin and spleen size z score. Children with a CPR < 114 were 20.7-fold more likely to have EV compared to children with CPR > 114. A risk score > -1.2 increased the likelihood of EV (odds ratio 7.47; 95%CI: 2.06-26.99). CONCLUSION: Children with portal hypertension with a CPR below 114 and a risk score greater than -1.2 are more likely to have present EV. Therefore, these two tests can be helpful in selecting children for endoscopy. | Marina Rossato Adami Cristina Targa Ferreira Carlos Oscar Kieling Vania Hirakata Sandra Maria Gonalves Vieira | 2013 | World Journal of Gastroenterology2013，19，13： | 4 |
| 2 | Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals 显示文摘 | Bazzoni F Rossato M Fabbri M | 2009 | Proc Nat Acad Sci U S A2009，106，： | 1 |
| 3 | Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis显示文摘 | Zecchin KG Rossato FA Raposo HF | 2011 | Lab Invest2011，91，2： | 1 |
| 4 | On the participation of mTOR in recognition memory显示文摘 | Myskiw JC Rossato JI Bevilaqua LR | 2008 | Neurobiol Learn Mem2008，89，3： | 1 |
| 5 | Hand rejuvenation using intense pulsed light 显示文摘 | Goldman A Prati C Rossato F | 2008 | Cutan Med Surg2008，12，3： | 1 |
| 6 | Cefepime induced en-cephalopathy:clinical and electroencephalo-graphic features in sevenpatients显示文摘 | Bragatti JA Rossato R Ziomkowski S | 2005 | Arq Neuropsiquiatr2005，63，1： | 1 |
| 7 | Current Perspectives of therapeutic patient education in Italy显示文摘 | Marcolongo R Rossato E Pavan V | | 0，，： | 1 |
| 8 | Dopamine controls persistence of long-term memory storage 显示文摘 | Rossato JI Bevilaqua LRM Izquierdo I | 2009 | Science2009，325，： | 1 |
| 9 | Role of androgens inerectile function显示文摘 | Foresta C Caretta N Rossato M | 2004 | J Uroloy2004，171，61： | 1 |
| 10 | Antisperm antibodies in inflammatory bowel disease显示文摘 | Rossato M Forests C | 2004 | Arch Intern Med2004，164，20： | 1 |
| 11 | Induction and regulatoryfunction of miR-9 in human monocytes and neutrophils exposed toproinfl ammatory signals显示文摘 | Bazzoni F Rossato M Fabbri M | 2009 | Proc Natl Acad Sci USA2009，106，13： | 1 |
| 12 | Liquid chromatographic assay of dimetridazole, ipronidazole, and ronidazole in feeds and premixes显示文摘 | TOLLOMELLI B LAFFI R ROSSATO S | 1992 | Journal of AOAC International1992，75，4： | 1 |
| 13 | Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco显示文摘 | Bortesi L Rossato M Schuster F | 2009 | BMC Biotechnol2009，19，9： | 1 |
| 14 | Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals显示文摘 | Bazzoni F Rossato M Fabbri M | 2009 | Proc Natl Acad Sci USA2009，106，13： | 1 |
| 15 | Ultrasound evaluation of ulnar neuropathy at the elbow: correlation with electrophysiological studies 显示文摘 | Volpe A Rossato G Bottanelli M | 2009 | Rheumatology2009，48，9： | 1 |
| 16 | Cefepime-in-duced encephalopathy:clinical and electroencephalographic features in seven patients显示文摘 | Bragatti JA Rossato R Ziomkowski S | 2005 | Arq Neuropsiquiatr2005，63，1： | 1 |
| 17 | The novel hormone INSL3 is expressed in human testicular Leydig cell tumors : a clinicaland immunohistoohemical study显示文摘 | Rossato M Tavolini IM Calcagno A | 2011 | Urol Oncol2011，29，1： | 1 |
| 18 | Pituitary adenylate cyclase-activating polypeptide stimulates rat Leydig cells steroidogenesis through a novel transduction pathway显示文摘 | Rossato M Nogara A Gottardello F | 1997 | Endocrinology1997，138，8： | 1 |
| 19 | IL 10-induced microR- NA-187 negatively regulates TNF a, IL-6, and IL-12p40 pro- duction in TLR4-stimulated monocytes显示文摘 | Rossato M Curtale G Tamassia N | 2012 | Proceedings of the National Academy of Sciences of the United States of America2012，109，18： | 1 |
| 20 | Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression,mitochondrial activation and heat production显示文摘 | Rossato M Granzotto M Macchi V | 2014 | Mol Cell Endocrinol2014，383，12： | 1 |
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