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	题名	作者	年代	出处	被引量
1	机械负荷调节猪腰椎间盘细胞表达α5β1整合素的体外研究显示文摘目的研究α5β1整合素在体外培养的猪腰椎间盘细胞中的表达和机械负荷对其的影响。方法取10只年龄5~6周、体重25~30kg的猪,处死后12h内,无菌条件下切取完整的腰椎,剔除腰椎周围的韧带和软组织,尤其是椎间盘周围的韧带。从腹侧一次性切开椎间盘取出髓核(nucleuspulpous,NP),仔细分离纤维环(anulusfibrous,AF),将两者立即置于Hanks平衡盐溶液中,制成细胞悬液。分别对腰椎间盘的AF和NP细胞施加1MPa、1Hz,3h/d,共3d的周期性液压,通过对细胞的形态学观察、Western免疫印迹和免疫组织化学染色,检测α5β1整合素在正常腰椎间盘AF细胞和NP细胞中的表达及周期性压力对其的影响。结果经周期性液压后,NP细胞的存活率大于90%,AF细胞的存活率大于85%,加压后的AF细胞和NP细胞均可见体积缩小。α5β1整合素在正常腰椎间盘AF细胞和NP细胞中的表达呈强阳性。Western免疫印迹结果显示:加压后α5β1整合素在AF细胞中的表达均明显减少,P值分别为0.000、0.003,与对照组比较差异有统计学意义;α5β1整合素在NP细胞中的表达也明显减少,P值分别为0.001、0.015,与对照组比较差异有统计学意义。结论机械负荷可引起腰椎间盘细胞中α5β1整合素的变化,提示α5β1整合素在腰椎间盘细胞中可能发挥力学传感器的作用。	于胜吉邱贵兴 Yang B Roth S Whyne C Yee AJ	2006	中华骨科杂志2006，26，6：	2
2	Effects of monnovalent, exchangeable cations and electrolytes on the relation between swelling pressure and interlayer distance in montmorillonite显示文摘	ZHANG F LOW P F ROTH C B	1995	J Colloid Interface Sci1995，173，1：	1
3	Thebioconcentration and metabolism of chlorpyrifos by the easternoyster, Crassostrea virginica 显示文摘	WOODBURN K B HANSEN S C ROTH G A	2003	Environmental Toxicologyand Chemistry2003，22，2：	1
4	Omeprazole-associated digoxin toxicity显示文摘	Cragin D J Roth B J	2007	South Med J2007，100，4：	1
5	Noninvasive assess ment of acute ureteral obstruction with diffusion-weighted MR imaging: a prospective study显示文摘	Thoeny H C Binser T Roth B	2009	Radiology2009，25，3：	1
6	Anemometrically determined roughness and displacement lengths in urban areas显示文摘	Grimmond C S B T S King M Roth M	1998	Boundary-Layer Meteor1998，89，：	1
7	Effects of monovalent, exchangeable cations and electrolytes on the relation between swelling pressure and interlayer distance in montmorillonite 显示文摘	ZHANG F S LOW P F ROTH C B	1995	Journal of Colloid and Interface Science1995，173，1：	1
8	Association of the NuMA region on chromosome 11q13 with breast cancer susceptibility显示文摘	Kammerer S Roth R B Hoyal C R	2005	PNAS2005，102，6：	1
9	Changes in the Si-O vibrations of smectite layers accompanying the sorption of interlayer water 显示文摘	YAN L B ROTH C B LOW P F	1996	Lagmuir1996，12，18：	1
10	Role of caspase-3 in ethanol-induced developmental neurodegeneration显示文摘	Young C Roth KA Klocke B J	2005	Neurobiol Dis2005，20，2：	1
11	Molecular characterization of an Enterovirus 71 causing neurological disease in Germany显示文摘	Kehle J Roth B Metzger C	2003	J Neurovirol2003，9，1：	1
12	Analysis of overconstrained mechanisms显示文摘	Mavroidis C Roth B	1995	ASME J Mechanical Design1995，117，：	1
13	Characterization of coding ends in thymocytes of scid mice:implications for the mechanism of VDJ recombination显示文摘	Zhu C Roth D B	1995	Immunity1995，2，：	1
14	Phase equilibria of the system SrO-CaO-CuO显示文摘	ROTH R S RAWN C J RITTER J J BURTON B P	1989	J Am Ceram Soc1989，72，8：	1
15	Experience, Service Opera- tions Strategy, and Services as Destinations : Foundations and Exploratory Investigation显示文摘	VOSS C ROTH A V CHASE R B	2008	Production and Operations Man- agement2008，17，3：	1
16	Noninve asiveassessment of acute ureteral obstruction with diffusion-weighted MR ima- ging : a prospective study显示文摘	Thoeny H C Binser T Roth B	2009	Radiology2009，252，3：	1
17	Zinc and copper status in ewes supplemented with sulfate-and amino acid-complexed forms of zinc and copper显示文摘	Hatfield P G Swenson C K Kott R W Ansotegui R P Roth N J Robinson B L	2001	Journal of Animal Science2001，79，1：	1
18	Manufacturing aspectsrelating to the effects of direct current on the tensile propertiesof metals 显示文摘	Ross C D Irvin D B Roth J T		Journal o f Engineering Materials andTechnology0，29，2：	1
19	Retinal and choroidal vascular occlusion after posterior sub=tenon friamcinolone injection显示文摘	LOWDER C Y ROTH D B	2002	Am J Ophthalmol2002，134，1：	1
20	Onyx in an experimental aneurysm model:histological and angiographic results显示文摘	Struffert T Roth C Romeike B	2008	J Neurosurg2008，109，：	1

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