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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Anticorrosion behavior of conversion coatings obtained from unbuffered cerium salts solutions on AA6061-T6显示文摘The anticorrosive properties of cerium based conversion coatings deposited on AA6061-T6 alloy by immersion in unbuffered cerium chloride and cerium nitrate solutions in the presence of hydrogen peroxide were investigated and characterized by potentiodynamic polarization(PDP) and electrochemical impedance spectroscopy(EIS) in 0.5 mol/L NaCl aqueous solution.The microstructure and chemicalcomposition of the protective films were examined by scanning electron microscopy(SEM) and energy dispersive X-ray spectroscopy(EDS).It was found that the best corrosion protection was afforded by the samples treated during 600 s in cerium chloride solution at pH values~5.5-4,showing higher amounts of cerium and polarization resistance values greater than 10 Ω m2.Moreover,an ennoblement of the corrosion potential and decreasing of the cathodic and anodic currents were obtained compared with the cerium nitrate solutions application.Thisbehavior was attributed to the influence of the deposition parameters such as type of the salt anion,i.e.,chelating effect and chaotropic characteristics,pH fluctuations in the conversion solution and deposition time. | KIYOTA Sayuri VALDEZ Benjamin STOYTCHEVA Margarita ZLATEV Roumen BASTIDAS Jose Maria | 2011 | Journal of Rare Earths2011，29，10： | 11 |
| 3 | Definition of colorectal anastomotic leakage: A consensus survey among Dutch and Chinese colorectal surgeons显示文摘AIM To determine the level of consensus on the definition of colorectal anastomotic leakage(CAL) among Dutch and Chinese colorectal surgeons.METHODS Dutch and Chinese colorectal surgeons were asked to partake in an online questionnaire. Consensus in the online questionnaire was defined as > 80% agreement between respondents on various statements regarding a general definition of CAL,and regarding clinical and radiological diagnosis of the complication.RESULTS Fifty-nine Dutch and 202 Chinese dedicated colorectal surgeons participated in the online survey. Consensus was found on only one of the proposed elements of a general definition of CAL in both countries: ‘extravasation of contrast medium after rectal enema on a CT scan'. Another two were found relevant according to Dutch surgeons: ‘necrosis of the anastomosis found during reoperation',and ‘a radiological collection treated with percutaneous drainage'. No consensus was found for all other proposed elements that may be included in a general definition.CONCLUSION There is no universally accepted definition of CAL in the Netherlands and China. Diagnosis of CAL based on clinical manifestations remains a point of discussion in both countries. Dutch surgeons are more likely to report ‘subclinical' leaks as CAL,which partly explains the higher reported Dutch CAL rates. | Stefanus J van Rooijen Audrey CHM Jongen Zhou-qiao Wu Jia-fu Ji Gerrit D Slooter Rudi MH Roumen Nicole D Bouvy | 2017 | World Journal of Gastroenterology2017，23，33： | 4 |
| 4 | EBSD表征变形后退火Al7075/石墨烯纳米片/碳纳米管复合材料显示文摘研究变形后退火对碳纳米管(CNTs)和石墨烯纳米片(GNPs)增强热轧Al7075基复合材料显微组织演变的影响。对搅拌铸造样品进行多道次热轧,然后在450℃下退火4 h。采用SEM、EDS和EBSD技术观察材料的显微组织演变。EBSD数据显示,添加体积分数(下同)为0.87%的GNPs和CNTs可明显抑制再结晶的发生。当添加0.96%的CNTs时,再结晶受到部分抑制。而当添加0.92%的GNPs时,明显加快了粒子激发形核(PSN)机制导致的再结晶。在有增强相存在的情况下,再结晶晶粒的体积分数与PSN的产生有显著的关系。主要织构的强度和类型都取决于增强相的种类。 | Siavash IMANIAN GHAZANLOU Baitallah EGHBALI Roumen PETROV | 2021 | Transactions of Nonferrous Metals Society of China2021，31，8： | 4 |
| 5 | Brownian Motion and the Temperament of Living Cells显示文摘The migration of living cells usually obeys the laws of Brownian motion.While the latter is due to the thermal motion of the surrounding matter,the locomotion of cells is generally associated with their vitality.We study what drives cell migration and how to model memory effects in the Brownian motion of cells.The concept of temperament is introduced as an effective biophysical parameter driving the motion of living biological entities in analogy with the physical parameter of temperature,which dictates the movement of lifeless physical objects.The locomemory of cells is also studied via the generalized Langevin equation.We explore the possibility of describing cell locomemory via the Brownian self-similarity concept.An heuristic expression for the diffusion coefficient of cells on structured surfaces is derived. | Roumen Tsekov Marga C.Lensen | 2013 | Chinese Physics Letters2013，30，7： | 3 |
| 6 | Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma显示文摘 | Roumen RMH Redl H Schlag G | 1995 | Crit Care Med1995，23，3： | 1 |
| 7 | Detection,treatment and outcome ofisolated supraclavicular recurrence in 42 patients with invasive breastcarcinoma显示文摘 | vander Sangen MJ Coebergh JW Roumen RM | 2003 | Cancer2003，98，1： | 1 |
| 8 | Impact of 3-year lifestyle intervention on postprandial glucose metabolism:the SLIM study显示文摘 | Roumen C Corpeleijn E Feskens EJ | 2008 | Diabet Med2008，25，5： | 1 |
| 9 | Bishop score and risk of cesarean delivery after induction of labor in nulliparous women 显示文摘 | Vrouenraets FP Roumen FJ Dehing C J | 2005 | Obstet Gyneco12005，105，4： | 1 |
| 10 | Inflammatory mediators in relation to the development of multiple organ failure in patients after sever blunt traurna显示文摘 | ROUMEN R M REDL H SCHLAG G | 1995 | Crit Care Med1995，23，： | 1 |
| 11 | Bleeding after excision of breast lumps显示文摘 | Bakker XR Roumen RM | 2002 | Eur J Surg2002，168，7： | 1 |
| 12 | Antiamyloid strategies for treatment of Alzheimer's disease显示文摘 | Roumen N Richardson JS | 1998 | Drugs Today1998，34，8： | 1 |
| 13 | Impact of 3-year lifestyle intervention on postprandial glucose metabo- lism : the SLIM Study 显示文摘 | ROUMEN C CORPELEIJN E FESKENS E J | 2008 | Diabet Med2008，25，5： | 1 |
| 14 | Small differerntial interactiongs for partial re sisitance in rice varieties to virulent isolates of the blast pathogen显示文摘 | Roumen E C | 1992 | Euphytica1992，64，： | 1 |
| 15 | Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma显示文摘 | Roumen RMH Redl H Schlag G | 1995 | Crit Care Med1995，23，： | 1 |
| 16 | Mechanical bowel preparation or not?Outcome of a multicenter,randomized trial in elective open colon surgery显示文摘 | Fa-Sj-Oen P Roumen R Buitenneg J | 2005 | Dis Colon Rectum2005，48，8： | 1 |
| 17 | Bishop score and risk of cesarean delivery after induction of labor in nulliparous women显示文摘 | Vrouenraets FP Roumen FJ Dehing CJ | 2005 | Obstet Gynecol2005，105，： | 1 |
| 18 | Early versus late epidural analgesia and risk of instrumental delivery in nuliiparous women: A systematic review显示文摘 | Wassen M M Zuijlen J Roumen F J | 2011 | B JOG2011，118，6： | 1 |
| 19 | Efficacy, toler- ability and acceptability of a novel contraceptive vaginal ring re- leasing etonogestrel and ethinyloestradiol 显示文摘 | ROUMEN FJ APTER D MULDERS TM | 2001 | Hum Reprod2001，16，3： | 1 |
| 20 | Fiber-optic liquid-level sensor 显示文摘 | Ivan Kassamakov Roumen Kakanakov | 1997 | Sensors and Actuators1997，58，： | 1 |
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