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| 1 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 2 | Impact of polymer films thickness and cavity size on polymer flow during embossing: Toward proces design rules for nanoimprint lithography显示文摘 | ROWLAND H D SUN A C SCHUNK P R | 2005 | Journal of Micromechanics and Microengineering2005，15，： | 1 |
| 3 | Intestinal adenomatosis in the pig:Immunofluorescent and electron microscopic studies显示文摘 | Rowland A C Lawson G H K | 1974 | Res Vet Sci1974，17，： | 1 |
| 4 | Porcine reproductive and respiratory syndrome virus:an update on an emerging and re-emerging viral disease of swine显示文摘 | Lunney J K Benfield D A Rowland R R | | 0，，： | 1 |
| 5 | Effective daily treatment with clomipramine in men with premature ejaculation when 25 mg (as required ) is ineffective 显示文摘 | Rowland DL De Gouveia Brazao CA Koos Slob A | 2001 | BJU Int2001，87，4： | 1 |
| 6 | Necrotic enteritis and regional iletis in pigs at slaughter显示文摘 | Rowland A C Hutings D A | 1978 | Vet Rec1978，103，： | 1 |
| 7 | Applications of anion chromatography in terrestrial environmental research 显示文摘 | WOODS C ROWLAND A P | 1997 | J Chromat A1997，789，： | 1 |
| 8 | Substrate complexes of hepatitis C virus RNA polymerase(HC-J4):structural evidence for nucleotide import and de-novo initiation显示文摘 | O'Farrell D Trowbridge R Rowlands D J(a)ger J | | 0，，04： | 1 |
| 9 | Selection of rod mills,ball mills,pebble mills and regrind mills design and installation of comminution circuits显示文摘 | ROWLAND C A | 1982 | AIME1982，，： | 1 |
| 10 | Socioe-conomic position, lifestyle factors and age at naturalmenopause: a systematic review and meta-analyses of studiesacross six continents显示文摘 | Schoenaker D A J M Jackson C A Rowlands J V | 2014 | International journal of epidemiology2014，43，5： | 1 |
| 11 | Reducing whole body physiologically based pharmacokinetic models using global sensitivity analysis: diazepam case study显示文摘 | Gueorguieva I Nestorov I A Rowland M | 2005 | Journal of Pharmacokinetics and Pharmacodynamics2005，33，1： | 1 |
| 12 | Phospholipase and lysophospholipase activity of rat eosinophil leukocytes显示文摘 | Ottolenghi A Rowland JT | 2002 | Arch Biochem Biophys2002，406，2： | 1 |
| 13 | An eicosapentaenoic acid supplement versus megestrol acetate versus both for patients with cancer-associated wasting: a North Central Cancer Treatment Group and National Cancer Institute of Canada collaborative effort 显示文摘 | Jatoi A Rowland K Loprinzi CL | 2004 | J Clin Oncol2004，22，12： | 1 |
| 14 | Prebiotic effects: metabolic and health benefits显示文摘 | Roberfroid M Gibson G R Hoyles L McCartney A L Rastall R Rowland I Wolvers D Watztl B Szajewska H Stahl B Guarner F Respondek F Whelan K Coxam V Davieco M Laotoing L Wittrant Y Delzenne N Cani P Neyrinek A Meheust A | 2010 | British Journal of Nutrition2010，104，2： | 1 |
| 15 | Functional analysis of Avr9/Cf - 9 rapidly elicited genes identifies a protein kinase, ACIK1, that is essential for full Cf9 -dependent disease resistance in tomato显示文摘 | Rowland O Ludwig A A Merrick C J | 2005 | Plant Cell2005，17，： | 1 |
| 16 | Impact of Polymer Film Thickness and Cavity Size on Polymer Flow during Embossing:toward Process Design Rules for Nanoimprint Lithography显示文摘 | Rowland H D Sun A C Schunk P R | 2005 | Journal of Micromechanics and Microengineering2005，15，： | 1 |
| 17 | Porcine reproductive and respiratory syndrome virus: an update on an emerging and re-emerging viral disease of swine显示文摘 | Lunney J K Benfield D A Rowland R R | 2010 | Virus Res2010，154，12： | 1 |
| 18 | Comparative analysis of expressed sequence tags from cold - acclimated and non - acclimated leaves of Rlwdodendron catawbiere Michx显示文摘 | WEIH DHANARAJ A L ROWLAND L J | 2005 | Planta2005，221，5： | 1 |
| 19 | Analysis of gene expression associated with cold acclimation in blueberry floral buds using expressed sequence tags 显示文摘 | DHANARAJ A L SLOVIN J P ROWLAND L J | 2004 | Plant Sci2004，166，： | 1 |
| 20 | Development of ESTPCR markers for DNA fingerprinting and genetic relationship studies in blueberry显示文摘 | Rowland L J Mehra S Dhanaraj A | 2003 | J Amer Soc Hort Sci2003，128，： | 1 |
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