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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Germanium recovery from gasification fly ash: Evaluation of end-products obtained by precipitation methods 显示文摘 | ARROYO F FONT O FERNANDEZ-PEREIRA C QUEROL X JUAN R RUIZ C COCA P | 2009 | Journal of Hazardous Materials2009，167，123： | 1 |
| 3 | Effect of dryi/lg medium on residual moisture content and viability of freeze - dried Lactic acid bacteria显示文摘 | De Valdez G F De Giori G S De Ruiz Holgado A P | | 0，，02： | 1 |
| 4 | Comparative study of the efficiency of some additives in protecting lactic acid bacteria against freeze-drying 显示文摘 | De Valdez G F de Giori G S de Ruiz Holgado A P | 1983 | Cryobiology1983，20，： | 1 |
| 5 | Bile salts hydrolase plays a key role on cho- lesterol removal by Lactobacillus reuteri显示文摘 | TARANTO M P SESMA F DE RUIZ HOLGADO A P | 1997 | Biotech- nology Letters1997，19，9： | 1 |
| 6 | Restoration SPOT images using PSF-drived deconvolution filters 显示文摘 | Ruiz C P Ariza Lopez F J | 2002 | International Journal of Remote Sensing2002，23，12： | 1 |
| 7 | Spatial pattern analysis of dominant species in the Prepuna: Gaining insight into community dynamics in the semi-arid, subtropical Andes显示文摘 | Lopez R P Alcazar D L Ruiz F Z | 2010 | Journal of Arid Environments2010，74，11： | 1 |
| 8 | Increased resistance to quinolones in Campylobacter jejuni: a genetic analysis of gyrA gene mutations in quinolone-resistant clinical isolates 显示文摘 | Ruiz J Goni P Marco F | 1998 | Microbiol Immunol1998，42，3： | 1 |
| 9 | Characterization of digestive proteases in the weevil Aubeonymus mariaefranciscae and effects of proteinase inhibitors on larval development and survival显示文摘 | Ortego F Farinos G P Ruiz M | 1998 | Entomol Exp Appl1998，88，： | 1 |
| 10 | Acknowledgment-Based Broadcast Protocol for Reliable and Efficient Data Dissemination in Vehic- ular Ad-hoc Networks显示文摘 | Ros F Ruiz P Stojmenovic | 2012 | IEEE Transactions on Mobile Com- puting2012，11，1： | 1 |
| 11 | The active role of CO2 at low temperature in oxidation processes: The case of the oxi- dative dehydrogenation of propane on NiMoO4 catalysts显示文摘 | Dury F Gaigneaux E M Ruiz P | 2003 | Appl Catal A: General2003，242，1： | 1 |
| 12 | Density multiplication and improved lithography by directed block copolymer assembly显示文摘 | Ruiz R Kang H Detcheverry F A Dobisz E Kercher D S Albrecht T R de Pablo J J Nealey P F | | 0，，5891： | 1 |
| 13 | Bismuth-promoted palladium catalysts for the selective oxidation of glyoxal into glyoxalic acid显示文摘 | Alardin F Ruiz P Delmon B | 2001 | Appl Catal A:Gen2001，215，： | 1 |
| 14 | Impaired function Fc-gamma receptor and ba cterial infection in alcoholic cirrhosis显示文摘 | Gomez F Ruiz P Schreiber AD | 1994 | N Eng1 J Med1994，331，： | 1 |
| 15 | Stability of bimetallic Bi-Pd and Pb-Pd carbon-supported catalysts during their use in glyoxal oxidation显示文摘 | Alardin F Delmon B Ruiz P | 2000 | Catal Today2000，61，： | 1 |
| 16 | Efficacy of sildenafil as a rescue therapy for patients with severe pulmonary arterial hypertension and given long-term treatment with prostanoids: 2-year experi ence显示文摘 | RUIZ M J ESCRIBANO P DELGADO J F | 2006 | J Heart Lung Transplant2006，25，： | 1 |
| 17 | Aberrant expression of MUC4 in ovarian carcinoma:diagnostic significance alone and in combination with MUC1 and MUC16(CA125) 显示文摘 | Chauhan S C Singh A P Ruiz F | 2006 | Mod Pathol2006，19，10： | 1 |
| 18 | Bismuth -promo- ted palladium catalysts for the selective oxidation of glyoxal into glyoxalic acid 显示文摘 | Alardin F Ruiz P Delmon B | 2001 | Applied Catalysis A: General2001，215，： | 1 |
| 19 | Helicobacterpylori causes hyperproliferation of the gastric epithelium: pre and post eradication indices of proliferation cell nuclear antigen显示文摘 | Brenes F Ruiz B Correa P | 1993 | Am J Gastroenterol1993，88，4： | 1 |
| 20 | Stability of bimetallic Bi - Pd and Pb - Pd carbon- supported catalysts during their use in glyoxal oxidation 显示文摘 | Alardin F Ruiz P Delmon B | 2000 | Catalysis Today2000，61，： | 1 |
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