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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Nitrification with high nitrite accumulation for the treatment of wastewater with high ammonia concentration显示文摘 | G Ruiz D Jeison R Chamy | 2002 | Water Research2002，，6： | 2 |
| 3 | Nitrification with high nitrite accumulation for the treatment of wastewater with high ammonia concentration显示文摘 | RUIZ G JEISON D CHAMY R | 2003 | Water Research2003，37，6： | 1 |
| 4 | Nitrification with high nitrite accumulation for the treatment of wastewater with high ammonia concentration显示文摘 | Ruiz G Jeison D Chamy R | 2003 | Wat Res2003，37，6： | 1 |
| 5 | Inducible nitric oxide synthase,nitrotyrosine,and apoptosis in Helicobacter pylori gastritis:effect of antibiotics and antioxidants 显示文摘 | Mannick EE Bravo LE Zarama G Realpe JL Zhang XJ Ruiz B Eonthan ETH Mera R Miller MJL Correa P | 1996 | Cancer Res1996，56，： | 1 |
| 6 | A computer model for teaching the dynamic behavior of AC contac- tors显示文摘 | RUIZ J R ESPINOSA A G ROMERAL L | 2010 | IEEE Transactions on Education2010，53，2： | 1 |
| 7 | Explicit Finite Element Modeling of Static Crack Propagation in Reinforced Concrete显示文摘 | Yu R Ruiz G | | 0，，03： | 1 |
| 8 | Nitrification with high nitrite accumulation for the treatment of wastewater with high ammonia concentration显示文摘 | Ruiz G Jeison D Chamy R | 2003 | Water Res2003，37，： | 1 |
| 9 | Nitrification with high nitrite accumulation for the treatment of wastewater with high ammonia concentration 显示文摘 | RUIZ G JETSON D CHAMY R | 2003 | Water Research2003，37，6： | 1 |
| 10 | Nitrification with high nitrite accumulation for the treatment of wastewater with high ammonia concentration显示文摘 | Ruiz G Jeison D Chamy R | 2003 | War Res2003，12，3： | 1 |
| 11 | Rate effect on the mechanical properties of eight types of high strength concrete and comparison with FIB MC2010 显示文摘 | ZHANG X RUIZ G YU R C POVEDA E PORRAS R | 2012 | Construction and Building Materials2012，30，： | 1 |
| 12 | The effect of a ruminal nitrogen (N) deficiency in dairy cows: evaluation of the Cornell net carbohydrate and protein system ruminal N deficiency adjustment 显示文摘 | Ruiz R Albrecht G L Tedeschi L O | 2002 | Journal of Animal Science2002，85，： | 1 |
| 13 | Connective tissue growth factor is a biomarker and mediator ofkidney allograft fibrosis显示文摘 | Cheng O Thuillier R Sampson E Schultz G Ruiz P Zhang X etal | 2006 | Am J Transplant2006，406，： | 1 |
| 14 | Numerical investigation on the dynamic behavior of advanced ceramics显示文摘 | Yu R C Ruiz G Pandolfi A | 2004 | Engineering Fracture Mechanics2004，71，： | 1 |
| 15 | Characterization by computed X-ray tomography of the evolution of the pore structure of a dolomite rock during freeze-thaw cyclic tests 显示文摘 | Ruiz de Argandona V G Rey A R Celorio C | 1999 | Physics and Chemistry of the Earth Part A: Solid Earth and Geodesy1999，24，7： | 1 |
| 16 | Nitrification with high nitriteaccumulation for the treatment of wastewater with high ammoniaconcentration显示文摘 | Ruiz G Jeison D Chamy R | 2003 | Water Research2003，37，6： | 1 |
| 17 | Extended self-similarity in the dissipation range of fully developed tur- bulent 显示文摘 | BENZI R CILIBERTO S RUIZ CHAVARRIA G | 1993 | Europhys Lett1993，24，4： | 1 |
| 18 | Optimization of biomass fuelled systems for distributed power generation using particle swarm optimization 显示文摘 | Reche Lopez P Comes G M Ruiz R N | 2008 | Electric Power Systems Research2008，78，8： | 1 |
| 19 | Free vibration of soils during large earthquakes 显示文摘 | Ruiz S Saragoni G R | 2009 | Soil Dynamics and Earthquake En- gineering2009，29，： | 1 |
| 20 | Nitrification with high nitrite accumulation for the treatment of aastewater with high ammonia concentration显示文摘 | RUIZ G JEISON D CHAMY R | 2003 | War Res2003，37，6： | 1 |
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