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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | Analytic view to concordance be- tween electrocochleography and caloric test in Meniere's disease显示文摘 | Bulent S Serdar K Deniz S | 2008 | Eur Arch Otorhinolaryngol2008，265，10： | 1 |
| 4 | Right ventricular penetration and cardiac tamponade as a late complication of Kirschner wire placement in the sternoclavicular joint显示文摘 | Oner G Alpay T S Bulent B | 2005 | Interact Cardio Vasc Thorac Surg2005，4，： | 1 |
| 5 | Survey over image thresholding techniques and quantitative performance evaluation显示文摘 | Mehmet S Bulent S | 2004 | Journal of Electronic Imaging2004，13，1： | 1 |
| 6 | Atypical presentation of human bocavirus: Severe respiratory tract infection complicated with encephalopathy显示文摘 | Hacer Akturk Guntulu S?k Nuran Salman Murat Sutcu Burak Tatli Meral Akcay Ciblak Oguz Bulent Erol Selda Hancerli Torun Agop Citak Ayper Somer | 2015 | J. Med. Virol2015，，： | 1 |
| 7 | Multi-scale modeling of localized heating caused by ion bombardment 显示文摘 | MICHAEL T M BULENT H S LIN S | 2011 | Nuclear Instrument and Methods in Physics Research B2011，272，： | 1 |
| 8 | Ovarian ectopie pregnancy after intracytoplasmic sperm injection显示文摘 | Cem S A Bulent B llkkan D | 2004 | Obstet Gyneeol Reprod Biol2004，112，： | 1 |
| 9 | Steganalysis using image quality metrics 显示文摘 | Avciba I Memon N Bulent S | 2003 | IEEE Transaction on image processing2003，12，2： | 1 |
| 10 | Multiresolution face recognition显示文摘 | Hazin K E Bulent S | 2005 | Image and Vision Computing2005，23，5： | 1 |
| 11 | Statistical evaluation of image quality measures 显示文摘 | ISMAIL A BULENT S KHALID S | 2002 | Journal of Electronic Imaging2002，11，2： | 1 |
| 12 | The effects of lower supplementation levels of organically com- plexed minerals (zinc,copper and manganese) versus inorganic forms on hematological and biochemical pa- rameters in broilers显示文摘 | DEVRIM S A TAYLAN A BULENT O | 2010 | Ka fkas Univ Vet Fak Derg2010，16，4： | 1 |
| 13 | Correlation of elevated leptin levels in Amniotic fluid and maternalserum in neural tube defects显示文摘 | Mustafa B Ibrahim S S Bulent O | 2003 | Obstet Gynecol2003，101，： | 1 |
| 14 | Patients with Spontaneous Bacterial Peritonitis,and Malignant and Cirrhotic Ascites显示文摘 | Bulent Y Ramazan S Nuran I | 2005 | NotI Med Assoc2005，97，： | 1 |
| 15 | Shape-based hand recognition 显示文摘 | ERDEM Y ENDER K BULENT S | 2006 | IEEE Transactions on Image Pro- cessing2006，15，7： | 1 |
| 16 | Influence of occlusal forces on stress distribution in preloaded dental implant screws显示文摘 | Alkan I Atilla S Bulent E | 2004 | J Prosthet Dent2004，91，4： | 1 |
| 17 | A comparative analysis of global hand appearance-based person recognition 显示文摘 | HELIN D BULENT S ERDEM Y | 2008 | Journal of Electronic Imaging2008，17，01： | 1 |
| 18 | Time synchronization in sensor networks:a survey显示文摘 | FIKRET S BULENT Y | 2004 | IEEE Network2004，7，8： | 1 |
| 19 | Correlation of elevated leptin levels in amniotic fluid and maternal serum in neural tube defects显示文摘 | Mustafa B lbrahim S S Bulent O | 2003 | Obstet Gynecol2003，101，3： | 1 |
| 20 | Survey over image thresholding techniques and quantitative performance evaluation显示文摘 | MEHMET S BULENT S | 2004 | Journal of Electronic Imaging2004，13，1： | 1 |
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