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| 1 | 口服抗凝剂指南(第三版)显示文摘英国血液学标准委员会(BCSH)1990年曾修订了口服抗凝剂指南以反映医学的发展并结合了医学评估的结果,1993年又发表了肝素指南,两份指南包括口服抗凝剂的适应范围和对抗凝治疗安排的建议。本次发表的新指南是考虑到需长期抗凝的患者数量迅速扩展,对其进行安全监控存在着实际困难。在过去5年中,临床抗凝治疗的患者数量增加了两倍多,并有继续增多的趋势,相应地就出现了组织上的问题。血液学家有责任帮助地方确定实验室检测方法与恰当的口服抗凝剂的治疗剂量,这需要国家和地方参与质量评估计划以及对临床工作的评估。 | Walker ID Machin S Baglin TP 吴淑燕 王兆钺 | 2004 | 国外医学(输血及血液学分册)2004，27，6： | 4 |
| 2 | 经导管动脉栓塞术治疗肝癌:最新临床证据显示文摘对不能接受根治性治疗如肝移植、肿瘤切除术或经皮射频消融术(radiofrequency ablation,RFA)的肝细胞肝癌(hepatocellular carcinoma,HCC)患者,经导管动脉化疗栓塞术(transarterial chemoembolization,TACE)或放疗栓塞术(transarterial radioembolization,TARE)是治疗的核心手段。近期研究证据显示:对于无血管侵犯、3 cm及以下单结节型HCC患者,TACE与肿瘤切除术及RFA后的5年总生存率相似。尽管已应用数十年,碘油(超液化碘油®,Lipiodol®Ultra Fluid,Guerbet,France)作为一种亲肿瘤性且不透射线的药物运输载体在肿瘤介入治疗中的地位依然重要。药物缓释微球(drug-eluting bead,DEB)是栓塞术中一种较新型的药物输送方式,既可维持药物浓度,也可持续释放抗癌药。现有三种DEB可供临床选择使用,即Tandem®(Celo Nova Biosciences Inc.),DC-Beads®(BTG,UK)和Hepa Sphere®(Bio Sphere Medical,Inc.,USA)。经动脉TARE已被证实可安全有效地运用于晚期肝癌及有肝血管侵犯的患者。两种放射性栓塞微粒可供临床选择使用,即SIR-Spheres®(Sirtex Medical Limited,Australia)和Thera Sphere®(BTG,UK)。本文总结肝癌经导管动脉治疗的关键临床试验。 | Yì-Xiáng J.Wáng Thierry De Baere Jean-Marc Idée Sébastien Ballet 邓敏 王毅翔 | 2015 | 临床与病理杂志2015，35，7： | 2 |
| 3 | Effects of Inspiratory Muscle Training in Patients With Chronic Heart Failure显示文摘 | Laoutaris ID Dritsas A Adamopoulos S | 2008 | J Am Coll Cardiol2008，52，23： | 1 |
| 4 | Pemetrexed: biochemical and celtular pharmacology, mechanisms, and clinical applications显示文摘 | Chattopadhyay S Moran RG Goldman ID | 2007 | Mol Cancer Ther2007，6，2： | 1 |
| 5 | Core decompression For early atraumatic osteonecrosis of the femoral head显示文摘 | Learmonth ID Maloon S Dall G | 1990 | J Bone Joint Surg(Br)1990，72，3： | 1 |
| 6 | Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells显示文摘 | Liu S Dontu G Mantle ID | 2006 | Cancer Res2006，66，12： | 1 |
| 7 | Pemmetrexed:biochemical and celluar pharmacology mechanisms and clinical application显示文摘 | Chattocpadhyky S Moran RG Goldman ID | | 0，，02： | 1 |
| 8 | Profiling the expression of cytochrome P450 in breast cancer显示文摘 | Murray GI Patimalla S Stewart KN Miller ID Heys SD | 2010 | Histopathology2010，57，2： | 1 |
| 9 | Quantitative computed tomography in the evaluation of spinal osteoporosis following spinal cord injury显示文摘 | Liu C Theodorou ID Theodorou S | 2000 | Osteoporosis Int2000，11，10： | 1 |
| 10 | Rapid detection of vanA and vanB genes directly from clinical specimens and enrichment broths by real-time multiplex PCR assay显示文摘 | Palladino S Kay ID Flexman JP | 2003 | J Clin Microbiol2003，41，6： | 1 |
| 11 | Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells显示文摘 | Liu S Dontu G Mantle ID | 2006 | Cancer Res2006，66，12： | 1 |
| 12 | A new histological grad- ing system to assess response of chemotherapy:prognostic sig- nificance and survival显示文摘 | Ogston KN Miller ID Payne S | 2003 | Breast2003，12，5： | 1 |
| 13 | Three independent mechanisms for arrest in G2 after ionizing radiation显示文摘 | Landsverk KS Patzke S Rein ID | | 0，，： | 1 |
| 14 | Improving loblolly pine somatic embryo maturation; comparison of somatic and zygotic embryo morphology,germination,and gene expression显示文摘 | Pullman G S Johnson S Peter G el id | 2003 | Plant Cell Rep2003，21，： | 1 |
| 15 | Comparison of complications of total thyroidectomy in malignant vs benign thyroid tumors 显示文摘 | Iddings D Saha S Walsh E | 2008 | ASCO Meeting Abstracts2008，26，17： | 1 |
| 16 | Skin closure after total hip replacement:a randomised controlled trial of skin adhesive versus surgical staples显示文摘 | Livesey C Wylde V Descamps S Estela CM Bannister GC Learmonth ID | | 0，，06： | 1 |
| 17 | Polyaniline- protonic Acid Doping to the Metallic Regime显示文摘 | Macdia rm id A G C h iang J C Huang W S | 1985 | Mol Cryst Liq Cryst1985，125，14： | 1 |
| 18 | Outcome in neonates with Ebstein's anomaly显示文摘 | Celermajer DS Cullen S Sullivan ID | 1992 | J Am Coll Cardiol1992，19，5： | 1 |
| 19 | Lrltrasotmd diagnosis of severe thrombotic placental damage in the second trimester:an observational study 显示文摘 | A/kazaleh F Viem S Simehen Id | 2004 | Ultrasound Obstet Gyneco12004，23，5： | 1 |
| 20 | A new histological grading system to assess response of breast cancers to primary chemotherapy: prognostic significance and survival 显示文摘 | Ogston KN Miller ID Payne S a al | 2003 | Breast2003，12，5： | 1 |
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