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| 1 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 2 | Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is a very deadly disease.HCC initiation and progression involve multiple genetic events,including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.Activation of oncogenes stimulates cell growth and survival,while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth.In this review,we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five years.These findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients. | Fang Wang Peter Breslin S J Wei Qiu | 2021 | Liver Research2021，5，4： | 3 |
| 3 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 4 | Interannual variability in net primary production and precipitate显示文摘 | Fang J Y Piao S L Tang Z Y | 2001 | Science2001，293，： | 2 |
| 5 | The state vector solution of axisymmetric Biot's consolidation problems for multilayered poroelastic media显示文摘 | Wang J G Fang S S | 2001 | Mechanics Research Communications2001，28，6： | 1 |
| 6 | Cleaner water using bimetallic nanoparticle catalysts显示文摘 | Michael S W Pedro J J A Yu-lun Fang | 2009 | Journal of Chemical Technology & Biotechnology2009，84，2： | 1 |
| 7 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 8 | Measurement of Particle Velocity and Characterization of Deposition in Aluminum Alloy Kinetic Spraying Process 显示文摘 | Wu J Fang H Yoon S | 2005 | Applied Surface Scince2005，252，： | 1 |
| 9 | Enhanced pulmonary inflammation following experimental intracerebral hemorrhage显示文摘 | Wu S Fang CX Kim J | 2006 | Exp Neurol2006，200，1： | 1 |
| 10 | Silicon rutile from podiform chromite of the Imohusa ophiolite, Tibel显示文摘 | Yang J S Bai W J Fang Q S | 2003 | Progress in Natural Sciences2003，，23： | 1 |
| 11 | The carbon balance of terrestrial ecosystems in China 显示文摘 | Piao S L Fang J Y Ciais P | 2009 | Nature2009，458，7241： | 1 |
| 12 | Interface dynamics and mechanisms of nanoindented alkanethiol self-assembled monolayers using molecular simulations 显示文摘 | Fang T H Chang W Y Lin S J | 2010 | Journal of Colloid and Interface Science2010，345，： | 1 |
| 13 | Dual seasonalpatterns for influenza,China显示文摘 | SHU Y L FANG L Q DE VLAS S J | 2010 | Emerging Infectious Disea-ses2010，16，3： | 1 |
| 14 | Variations in satellitederivedphenology in China's temperate vegetation显示文摘 | Piao S L Fang J Y Zhou L M | | 0，，： | 1 |
| 15 | Enhanced pulmonary inflam- mation following experimental intracerebral hemorrhage 显示文摘 | Wu S Fang CX Kim J | 2006 | Exp Neurol2006，200，1： | 1 |
| 16 | Interannual variations of monthly and seasonal normalized difference vegetation index(NDVI) in China from 1982 to 1999显示文摘 | Piao S L Fang J Y Zhou L M | 2003 | Journal of Geophysical Research2003，108，14： | 1 |
| 17 | Enhanced pulmonary inflammation following experimental intracerebral hemorrhage显示文摘 | Wu S Fang CX Kim J | 2006 | Exp Neurol2006，200，1： | 1 |
| 18 | State space solution of non-axisymmetric Biot consolidation problems for multilayered poroelastic media显示文摘 | Wang J G Fang S S | 2003 | International Journal of Engineering Science2003，41，15： | 1 |
| 19 | Analytical model for predicting shear strength of squat walls显示文摘 | HWANG S J Fang W H LEE H J | 2001 | J Struet Eng2001，127，1： | 1 |
| 20 | Nitrosylation:the prototypic redox-based signaling mechanism显示文摘 | STAMLER J S LAMAS S FANG F C | 2001 | Cell2001，106，： | 1 |
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