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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Expression of type X collagen, Indian hedgehog and parathyroid hormone related-protein in normal and tibial dysehondroplastic chick growth plates显示文摘 | WEBSTER S V FARQUHARSON C JEFFERIES D | 2003 | Avian Pathology2003，32，1： | 1 |
| 3 | High yield production of a human therapeutic protein in tobacco chloroplasts 显示文摘 | Jeffery M S Bradley G Julie G | 2000 | Natl Biotechn2000，18，： | 1 |
| 4 | Analysts' forecasts as proxies for investor beliefs in empirical research 显示文摘 | Jeffery S Abarbanel William N Lanen and Robert E Ver- recchia | 1995 | Journal of Accounting and Eco- nomics1995，20，： | 1 |
| 5 | Entrepreneurial Action and the Role of Uncertainty in the Theory of the Entrepreneur显示文摘 | Jeffery S Mcmullen Dean A Shepherd | 2006 | The Academy of Management Review2006，31，1： | 1 |
| 6 | Radio frequency identi-cation (RFID) implementation in the service sector: A custom- er-facing diffusion model显示文摘 | Lon'aine S Lee Kirk D Fiedler Jeffery S Smith | 2008 | International Journal of Production Eco- nomics2008，112，： | 1 |
| 7 | The Practice of Competency Modeling显示文摘 | Jeffery S Shipprann | 2000 | Personal Psychology2000，，： | 1 |
| 8 | Deconvolution from wave front sensing using the frozen flow hypothesis 显示文摘 | S M Jefferies M Hart | 2011 | Opt Express2011，19，3： | 1 |
| 9 | Unique in vivo properties of olfac- tory ensheathing cells that may contribute to neural repair and protec- tion following spinal cord injury 显示文摘 | Jeffery DK Karen LL Masanori S | 2009 | Neurosci Lett2009，3，： | 1 |
| 10 | A quantitative review of the effects of biochar application to soils on crop productivity using meta-analysis显示文摘 | Jeffery S Verheijen F G A van der Velde M | 2011 | Agriculture Ecosystems & Environment2011，144，： | 1 |
| 11 | Radio frequency identification (RFID) implementation in the service sector: A customer-facing diffusion model显示文摘 | Lorraine S Lee Kirk D Fiedler Jeffery S Smith | 2008 | International Journal of Production Economics2008，112，2： | 1 |
| 12 | A quantitative re-view of the effects of biochar application to soils on crop productivityusing meta-analysis显示文摘 | Jeffery S Verheijen F G A van der Velde M | 2011 | Agriculture Ecosystems & Environment2011，144，1： | 1 |
| 13 | A quantitative review of the effects of hiocher application to soils on crop productivity using meta-ana~ysis 显示文摘 | Jeffery S Verheijen F G Avander V M | 2011 | Agriculture Ecosystems and Environmental2011，144，： | 1 |
| 14 | Scurfin(FOXP3) acts as a repressor of transcription and regulates T cell activation显示文摘 | Schubert L A Jeffery E Zhang Y Ramsdell F Ziegler S F | 2001 | J Biol Chem2001，276，37： | 1 |
| 15 | The mechanism of premixing rosin sizes for neutral-alkaline papermaking 显示文摘 | Yong Z Jeffery S Hsieh | 2004 | Tappi2004，，9： | 1 |
| 16 | Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k显示文摘 | JEFFERIES H B FUMAGALLI S DENNIS P B | 1997 | Embo J1997，16，12： | 1 |
| 17 | Biochar application does not improve the soil hydrological function of a sandy soil显示文摘 | Jeffery S Meinders M B J Stoof C R | 2015 | Geoderma2015，25，： | 1 |
| 18 | Three composite finishing systems: a multisite in vitro evalua- tion显示文摘 | Jefferies S R Barkmeier W W Gwinnett A J | 1992 | J Esthet Dent1992，4，6： | 1 |
| 19 | Rapamycin suppresses 5TOP mRNA translation inhibition of p70 S6K显示文摘 | Jefferies HBJ Fumagalli S Dennis PB etal | 1997 | EMBO J1997，16，4： | 1 |
| 20 | One gene,two phenotypes:ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B显示文摘 | Afzal AR Jeffery S | 2003 | Hum Mutat2003，22，1： | 1 |
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