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| 1 | Outcome of gall bladder polypoidal lesions detected by transabdominal ultrasound scanning: A nine year experience显示文摘AIM: To determine the outcome of polypoidal lesions within the gall bladder (PLG) diagnosed by trans-abdominal scanning.METHODS: A nine-year (1993-2002) retrospective casenote review of all patients who underwent ultrasound scanning after referral to a single Upper GI Surgeon at a District General Hospital was conducted. Patients who were diagnosed with a PLG were included in our study. A database was constructed and patient details, investigations including ultrasound scan (USS) findings, treatment and histology and final diagnosis were recorded. RESULTS: Twenty-three (out of 651) patients were diagnosed pre-operatively by USS to have a polyp-likegall bladder lesion (PLG). Post cholecystectomy histological examination revealed 12 gallstones, 7 cholesterol polyps, 3 adenocarcinomas within polyps and 1 normal gall bladder. The specificity of USS in the diagnosis of PLG was 92.3%. All the true polyps were malignant. Overall USS had 66.66% sensitivity and 100% specificity in the pre-operative suspicion of malignancy. Using size greater than 10 mm as measured on USS as a cut-off, we find 100% sensitivity and 86.95% specificity with a positive predictive value of 50% in the diagnosis of malignancy in PLG.CONCLUSION: A large number of PLG are in fact calculi within diseased gall bladder. In cases of gall bladder polyps more then 10 mm in size on USS further imaging (crosssectional and/or EUS) is indicated prior to surgery. This will help in the optimal management of patients and avoid histological surprises. | D Chattopadhyay R Lochan S Balupuri BR Gopinath KS Wynne | 2005 | World Journal of Gastroenterology2005，11，14： | 23 |
| 2 | Lancet:世界心脏联盟全球心血管疾病预防展望显示文摘动脉粥样硬化性心血管疾病是世界头号致死致残因素,不成比例地影响着中低收入国家(LMIC)的居民。二十世纪六七十年代,心血管疾病被视为高收入国家的常见病,此后通过采取更好的预防措施(如改变生活方式、控制风险因素等),并广泛应用简单有效的紧急事件处理和二级预防措施,心血管疾病的年龄标准化死亡率得以减半。然而,即便在发达国家,所采取的这些行之有效的策略仍远远不够,如果在大多数高收入国家中推广,未来二十年心血管疾病的发生率将进一步降低。 | Yusuf S Wood D Ralston J Reddy KS | 2015 | 疾病监测2015，30，5： | 14 |
| 3 | Ileal inflammatory fibroid polyp causing chronic ileocolic intussusception and mimicking cecal carcinoma显示文摘Inflammatory fibroid polyp(IFP) is a rare,idiopathic pseudotumorous lesion of the gastrointestinal tract.While mostly reported as solitary gastric lesions,multiple cases of small bowel IFPs are also reported.It is a documented cause of intussusception in adults.In the case reports of ileal inflammatory fibroid polyps with intussusception,an emergent presentation with small bowel obstruction has been most often described.Here we depict a case of ileal inflammatory fibroid polyp presenting with chronic intermittent ileocolic intussusception,anemia and weight loss with an endoscopic appearance mimicking necrotic cecal carcinoma. | Naveen Gara John S Falzarano Whitney ML Limm Thomas S Namiki Laurie KS Tom | 2009 | World Journal of Gastrointestinal Oncology2009，1，1： | 3 |
| 4 | Mutations around interferon sensitivity-determining region:A pilot resistance report of hepatitis C virus 1b in a Hong Kong population显示文摘AIM: To explore mutations around the interferon sensitivity-determining region (ISDR) which are associated with the resistance of hepatitis C virus 1b (HCV-1b) to interferon-α treatment. METHODS: Thirty-seven HCV-1b samples were ob- tained from Hong Kong patients who had completed the combined interferon-α/ribavirin treatment for more than one year with available response data. Nineteen of them were sustained virological responders, while 18 were non-responders. The amino acid sequences of the extended ISDR (eISDR) covering 64 amino acids upstream and 67 amino acids downstream from the previously reported ISDR were analyzed. RESULTS: One amino acid variation (I2268V, P = 0.023) was significantly correlated with treatment outcomein this pilot study with a limited number of patients, while two amino acid variations (R2260H, P = 0.05 and S2278T, P = 0.05) were weakly associated with treatment outcome. The extent of amino acid variations within the ISDR or eISDR was not correlated with treatment outcome as previously reported. CONCLUSION: Three amino acid mutations near but outside of ISDR may associate with interferon treatment resistance of HCV-1b patients in Hong Kong. | Xiao-Ming Zhou Paul KS Chan John S Tam | 2011 | World Journal of Gastroenterology2011，17，48： | 3 |
| 5 | Independent regulation of skeletal growth by Ihh and IGF signaling显示文摘 | Long F Joeng KS Xuan S | 2006 | Dev Biol2006，298，1： | 1 |
| 6 | Random amplified poly morphic DNA of mosquito species and population (Diptera :Cull cidae) :techniques, statistical analysis, and applications显示文摘 | Kambhampati S Black WC Rai KS | 1992 | MedEntomology1992，29，6： | 1 |
| 7 | Blunt splenic injury: Operation versus angiographic embolization显示文摘 | Wahl WE Ahms KS Chen S | 2004 | Surgery2004，136，89： | 1 |
| 8 | Resection of the liver for colo rectal carcinoma metastases:a multi-institutional study of indications for res etion显示文摘 | Hughes KS Smion R Songhorabodi S | 1999 | Surgery1999，103，3： | 1 |
| 9 | Adjuvant chemohormonal therapy for primary breast cancer should be sequential instead of concurrent:initial results from intergroup trial 0100 (SWOG-8814)显示文摘 | Albain KS Green S J Ravdin PM | 2002 | Proc Am Soc Clin Oncol2002，21，： | 1 |
| 10 | Inhibition of intercellular communication bynickel(Ⅱ):antagonistic effect of magnesium显示文摘 | Miki H Kasprzak KS Kenney S | 1987 | Carcinogenesis1987，8，： | 1 |
| 11 | 显示文摘 | Schmidt KS Borkowski S Kurreck J | 2004 | Nucleic Acids Res2004，32，19： | 1 |
| 12 | Intracranial stenosis in Chinese patients with acute stroke显示文摘 | Wong KS Huang YN Gao S | 1998 | Neurology1998，50，3： | 1 |
| 13 | High sensitivity surface plasmon resonance sensor based on phase detection显示文摘 | Nelson S G Johnston KS Yee S S | 1996 | Sensors and actuators B1996，3536，： | 1 |
| 14 | Gene transfer of an engineered zinc finger protein enhances the anti-angiogenic defense system 显示文摘 | Yokoi K Zhang HS Kachi S Balaggan KS Yu Q Guschin D | 2007 | Mol Ther2007，15，11： | 1 |
| 15 | Structural and functional character- ization of the 5 '-upstream promoter factor Phox2b 显示文摘 | Hong S J Kim CH Kim KS | 2001 | J Neu- rochem2001，79，6： | 1 |
| 16 | Position of a sigmoid colon in right iliac fossa in children:A retrospective study显示文摘 | Saxena AK Sodhi KS Tirumani S | 2011 | J Indian Assoc Pediatr Surg2011，16，3： | 1 |
| 17 | Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis显示文摘 | Kim DJ Chan KS Sano S | 2007 | Mol Carcinog2007，46，8： | 1 |
| 18 | Central and Peripheral Effects of Ghrelin on Energy Balance, Food Intake and Lipid Metabolism in Tel- eost Fish 显示文摘 | Kang KS Yahashi S Matsuda K | 2011 | Peptides2011，32，11： | 1 |
| 19 | Effect of intrave- nous metoclopramide on intraocular pressure~ a prospective, randomized,double-blind,placebo-controlled study显示文摘 | Sudheera KS Bhardw~ N Yaddanapudi S | 2008 | J Post- grad Med2008，54，3： | 1 |
| 20 | AUF1 isoform - specific regulation of anti - intlanunatory ILl0 expression in monocytes 显示文摘 | Sarkar S Sinsimer KS Foster RL | 2008 | Journal of Interferon & Cytokine Re- search2008，28，11： | 1 |
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