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| 1 | Opioid growth factor and the treatment of human pancreatic cancer:A review显示文摘Opioid growth factor(OGF),chemically termed[Met5]-enkephalin,and its receptor,OGF receptor(OGFr),form a biological axis that tonically regulates cell proliferation by delaying the G1/S interface of the cell cycle under homeostatic conditions or in neoplasia.Modulation of the OGF-OGFr pathway mediates the course of pancreatic cancer,with exogenous OGF or upregulation of OGFr repressing growth of human pancreatic cancer cells in culture and in nude mice.OGF therapy alone or in combination with standard chemotherapies such as gemcitabine and 5-fluorouracil results in enhanced inhibition of DNA synthesis and tumor growth.Molecular manipulation of OGFr confirms that the receptor is specific for OGF’s inhibitory action.Preclinical studies have warranted PhaseⅠand PhaseⅡclinical trials using OGF infusions as a treatment for patients with advanced,unresectable pancreatic cancers.OGF,an endogenous neuropeptide,is a safe,non-toxic,and effective biotherapy that utilizes the OGF-OGFr axis to mediate pancreatic tumor progression. | Ian S Zagon Patricia J McLaughlin | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 2 | Development of EMD-based denoising methods inspired by wavelet thresholding显示文摘 | Kopsinis Y McLaughlin S | | 0，，04： | 2 |
| 3 | Use of polymerase chain reaction for rapid detection of gene insertions in whole yeast cells显示文摘 | Sathe G M OBrien S Mclaughlin M M | 1991 | Nucleic Acids Res1991，19，： | 2 |
| 4 | Prevention and delay in progression of human squan~ous cell carcinoma of the head and neck in nude mice by stable overexpression of the opioid growth factor receptor显示文摘 | McLaughlin PJ Krdner S Morgan CR | 2008 | Int J Oncol2008，33，4： | 1 |
| 5 | ACCF/AHA 2009 expert consensus docu- ment on pulmonary hypertension a report of the A- merican College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians显示文摘 | MCLAUGHLIN V V ARCHER S L BADESCH D B | 2009 | J Am Coil Cardiol2009，53，： | 1 |
| 6 | Delayed sternal closure after cardiac operations in a pediatric population 显示文摘 | Tabbutt S Duncan BW McLaughlin D | 1997 | Thorae Cardio- vase Surg1997，113，5： | 1 |
| 7 | Clinieal efficacy of two hypocaloric diets that vary in overweight patients with type 2 diabetes: comparison of moderate fat versus carbohydrate reductions显示文摘 | McLaughlin T Carter S Lamendola C | 2007 | Diabetes Care2007，30，7： | 1 |
| 8 | Performance of the GLRT for adaptive vector subspace detection显示文摘 | Raghavan R S Pulsone N and McLaughlin D J | 1996 | IEEE Transactions on Aerospace and Electronic Systems1996，32，4： | 1 |
| 9 | Use of polymerase chain reaction for rapid detection of gene insertions in whole yeast cells显示文摘 | Sathe G M O'Brien S McLaughlin M M | 1991 | Nucl Acids Res1991，19，17： | 1 |
| 10 | Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis:variables that affect performance显示文摘 | Marr K A Balajee S A McLaughlin L | 2004 | J Infect Dis2004，190，： | 1 |
| 11 | Development of EMD-based denoising methods inspired by wavelet thresholding显示文摘 | Kopsinis Y McLaughlin S | 2009 | IEEE Transactions on Signal Processing2009，57，4： | 1 |
| 12 | An FFT- based approach for fast acquisition in spread spectrum communication systems显示文摘 | Spangenberg S M Scott I McLaughlin S | 2000 | Wireless Personal Communi- cations2000，13，12： | 1 |
| 13 | Cancer risk among Danish women with cosmetic breast implants显示文摘 | Friis S Holmich LR McLaughlin JK | 2006 | Int J Cancer2006，118，4： | 1 |
| 14 | Proton pump in- hibitors and risk of gastric cancer: a population-based cohort study 显示文摘 | Poulsen AH Christensen S McLaughlin JK | 2009 | BJC2009，100，9： | 1 |
| 15 | Satellite Formation Flying Design and Evolution 显示文摘 | Chris S Richard B McLaughlin C A | 2001 | Journal of Spacecraft and Rockets2001，38，2： | 1 |
| 16 | A parallel decoder for low latency decoding of turbo product codes显示文摘 | Argon C McLaughlin S W | 2002 | IEEE Communications Letters2002，6，2： | 1 |
| 17 | Effects of air pollution on forests显示文摘 | McLaughlin S B | 1985 | Air Pollution Control Association1985，35，： | 1 |
| 18 | Security and privacy challenges in the smart grid显示文摘 | Mcdaniel P Mclaughlin S | 2009 | IEEE Security and Privacy2009，7，3： | 1 |
| 19 | Biological control of postharvcst diseases of grape,peach,and apple with yeasts Kloeckera apiculata and Candida guilliermondii显示文摘 | McLaughlin R J Wilson C L Dorby S | | 0，，05： | 1 |
| 20 | Characterisation of PMMA microfluidic channels and devices fabricated by hotembossing and sealed by direct bonding显示文摘 | A Mathur S S Roy M Tweedie S Mukhopadhyay S K Mitra J A McLaughlin | 2009 | Current Applied Physics2009，，9： | 1 |
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