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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | | 0，，： | 3 |
| 3 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | | 0，，1971： | 2 |
| 4 | Experimental Evaluation of Intelligent Assistance for Navigation 显示文摘 | Amant R S Long T Duiberg M S | 1998 | Knowledge-based Systems1998，11，1： | 2 |
| 5 | “Trends” and variations of global oceanic evaporation data sets from remote sensing显示文摘The variability in global oceanic evaporation data sets was examined for the period 1988-2000.These data sets are satellite estimates based on bulk aerodynamic formulations and include the NASA/Goddard Space Flight Center Satellite-based Surface Turbulent Flux version 2(GSSTF2),the Japanese-ocean flux using remote sensing observations(J-OFURO),and the Hamburg Ocean-Atmosphere Parameters and Fluxes from Satellite version 2(HOAPS2).The National Center for Environmental Prediction(NCEP)reanalysis is also included for comparison.An increase in global average surface latent heat flux(SLHF)can be observed in all the data sets.Empirical mode decomposition(EMD)shows long-term increases that started around 1990 for all remote sensing data sets.The effect of Mt.Pinatubo eruption in 1991 is clearly evident in HOAPS2 but is independent of the long-term increase.Linear regression analyses show increases of 9.4%,13.0%,7.3%,and 3.9% for GSSTF2,J-OFURO,HOAPS2 and NCEP,for the periods of the data sets.Empirical orthogonal function(EOF)analyses show that the pattern of the first EOF of all data sets is consistent with a decadal variation associated with the enhancement of the tropical Hadley circulation,which is supported by other satellite observations.The second EOF of all four data sets is an ENSO mode,and the correlations between their time series and an SOI are 0.74,0.71,0.59,and 0.61 for GSSTF2,J-OFURO,HOAPS2,and NCEP in that order.When the Hadley modes are removed from the remote sensing data,the residue global increases are reduced to 2.2%,7.3%,and <1% for GSSTF2,J-OFURO and HOAPS,respectively.If the ENSO mode is used as a calibration standard for the data sets,the Hadley mode is at least comparable to,if not larger than,the ENSO mode during our study period. | CHIU Long S CHOKNGAMWONG R XING Yukun YANG Ruixin SHIE Chung-Lin | 2008 | Acta Oceanologica Sinica2008，27，3： | 2 |
| 6 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and nonstationary time series analysis显示文摘 | Huang N E Shen Z Long S R | | 0，，1971： | 2 |
| 7 | Measurement of leaf and canopy photosynthetic C02 exchange in the field显示文摘 | Farageand P K Garcia R L | 1996 | Journal of Experimental Botany1996，47，304： | 1 |
| 8 | Chronic hypoxia modulates the interleukin-1β-stimulated inducible nitric oxide synthase pathway in cardiac myocytes显示文摘 | LONG C S KARLINER J S | 1997 | Circulation1997，96，6： | 1 |
| 9 | A confidence limit for theempirical mode decomposition and the Hilbert spectralanalysis显示文摘 | Huang N E Wu M C Long S R | 2003 | Proceedings of the Royal Society London:Series A2003，31，： | 1 |
| 10 | A Confidence Limit for the Empirical Mode Decomposition and Hilbert Spectral Analysis显示文摘 | Huang N E Wu M L Long S R | 2003 | Proceedings of the Royal Society of London2003，459，： | 1 |
| 11 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and nonstationary time series analysis 显示文摘 | Huang N E Zheng Shen Long S R | 1998 | Proceedings of the Royal Society A : Mathematical Physical and Engineering Sciences1998，454，1971： | 1 |
| 12 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings Of The Royal Society of London Series A-Mathematical Physical And Engineering Sciences1998，454，： | 1 |
| 13 | The empirical modedecomposition and the Hilbert spectrum for nonlinear andnon-stationary time series analysis显示文摘 | HUANG N E SHEN Z LONG S R | 1998 | Proceedings of theRoyal Society of London1998，454，1： | 1 |
| 14 | Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain- CoA acytransferase that functions in taxol biosynthesis 显示文摘 | Walker K Fujisaki S Long R M | 2002 | Proc Natl Acad Sci USA2002，99，12： | 1 |
| 15 | The empirical mode decomposition and the Hilbert spectrum for non- linear and non- stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings of the Royal Society of London Series A: Mathematical Physical and Engineering Sciences1998，454，： | 1 |
| 16 | A confidence limit for the empirical mode decomposition and Hilbert spectral analysis 显示文摘 | Huang N E Wu M L C Long S R | 2003 | Proceedings Royal of Society A2003，459，： | 1 |
| 17 | The empirical mode 34 decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings of the Royal Society A1998，，454： | 1 |
| 18 | Incidence of adverse biological effects within ranges of chemical concentrations in marine and estuarine sediments 显示文摘 | Long E R MacDonald D D Smith S L | 1996 | Environmental Management1996，19，1： | 1 |
| 19 | Improving photosynthetic effi ciency for greater yield 显示文摘 | Zhu X G Long S P Ort D R | 2010 | Annual Review of Plant Biolo gy2010，61，1： | 1 |
| 20 | The empirical mode decompo- sition and hilbert spectrum for nonlinear and nonstationary time series analysis显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings of the Royal Society of London SERIESA1998，454，： | 1 |
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