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| 1 | 高危患者目标血压与心血管病预后显示文摘指南推荐血压目标值应〈140/90 mmHg(1mmHg=0.133kPa)以减少心血管事件的发生。但与其他心血管病预后(如冠状动脉事件)相比,包括脑卒中及心力衰竭在内的心血管病预后与收缩压下降关系更密切。一些心血管事件(如冠状动脉事件)风险在收缩压低时亦增高,风险-收缩压关系呈J形曲线,而脑卒中与血压不是J形曲线关系。 | B?hm M Schumacher H Teo KK Lonn EM Mahfoud F Mann JF Mancia G Redon J Schmieder RE Sliwa K Weber MA Williams BYusuf S 曲浥晨 叶鹏 | 2017 | 中华高血压杂志2017，25，6： | 14 |
| 2 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 3 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 4 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 5 | 24h动态中心动脉收缩压和左心室质量的关系:一项前瞻性多中心研究显示文摘研究者在7个欧洲中心中调查左心室质量与肱动脉诊室血压以及肱动脉压和中心动脉动态收缩压之间的关系。使用校准的示波装置测量,经平均压/舒张压校准和转换函数计算中心动脉收缩压。由不知道血压值的单个操作者通过M型超声心动图测定左心室质量。研究者调查了未使用抗高血压药物的受试者289人(女性137人,平均年龄50.8岁)。 | 黄洁 叶鹏 Weber T Wassertheurer S Schmidt-Trucks?ss A Rodilla E Ablasser C Jankowski P Lorenza Muiesan M Giannattasio C Mang C Wilkinson I Kellermair J Hametner B Pascual JM Zweiker R Czarnecka D Paini A Salvetti M Maloberti A McEniery C | 2017 | 中华高血压杂志2017，25，11： | 2 |
| 6 | Analysis of gene function in somatic mammalian cells using small interfering RNAs显示文摘 | Elbashir S M Harborth J Weber K | 2002 | Methods2002，26，2： | 1 |
| 7 | Shorebird diet and size selection of nereid polychaetes in South Carolina coastal diked wetlands 显示文摘 | WEBER L M HAIG S M | 1997 | Journal of Field Ornithology1997，68，3： | 1 |
| 8 | 3-Hydroxypropionic acid as a nematicidal principle in endophytic fungi显示文摘 | Michael Schwarz Barbel Kopcke Roland W S Weber | 2004 | Phytochemistry2004，65，： | 1 |
| 9 | Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine:The VALUE randomised trial显示文摘 | Julius S Kjeldsen SE Weber M | 2004 | Lancet2004，363，9426： | 1 |
| 10 | Effect of ecological factors on the inhibitory spectrum and activity of bacteriocins 显示文摘 | Ganzle M G Weber S Hammes W P | 1999 | Intemational Journal of Food Microbiology1999，48，： | 1 |
| 11 | The role of frozen sectionanalysis of margins during breast conservation surgery显示文摘 | Weber S Storm FK Stitt J | 2000 | Cancer J Sci Am2000，6，1： | 1 |
| 12 | UV Laser Polishing of Thick Diamond Films for IR Windows 显示文摘 | S Gloor W Luthy H P Weber | 1999 | Aplied Surface Science1999，，138139： | 1 |
| 13 | Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK eomplexes显示文摘 | Eblen S T Slack J K Weber M J Catling A D | 2002 | Mol Cell Biol2002，22，60： | 1 |
| 14 | Categorization of Scope 3 Emissions for Streamlined Enterprise Carbon Footprinting 显示文摘 | Huang Y A Weber C L Matthews H S | 2009 | Environmental Science & Technology2009，43，22： | 1 |
| 15 | A survey of anycast in 1Pv6 networks 显示文摘 | WEBER S CHENG Liang | 2004 | IEEE Communications Magazine2004，42，1： | 1 |
| 16 | Diagnosis and ablation of atrial flutter using a high resolution,noncontact mapping system显示文摘 | Schmitt H Weber S Tillmanns H | 2000 | Pacing & clinical electrophysiolohy2000，23，12： | 1 |
| 17 | Adaptive isletspecific regulatory CD4^+-T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo显示文摘 | WEBER S E HARBERTSON J GODEBU E | 2006 | J Immunol2006，176，8： | 1 |
| 18 | Peptides and polypeptides as modulators of the immune response:Thymopentin-An example with unknown mode of action 显示文摘 | Gonser S Weber E Folkers G | 1999 | Pharm Acta Helv1999，73，： | 1 |
| 19 | Myocardial fibrosis: functional significance and regulatory factors 显示文摘 | Weber K T Brilla C G Janicki J S | 1993 | Cardiovas Res1993，27，： | 1 |
| 20 | Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine:the VALUE randomised trial显示文摘 | Julius S Kjeldsen SE Weber M | 2004 | Lancet2004，363，： | 1 |
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