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| 1 | IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients显示文摘AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele carriers.METHODS:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as controls.Genomic DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed primer.Then the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) genotyping.The presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain reaction.The role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically analyzed.RESULTS:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,respectively.SVR rates for the C/C allele were lower than other HCV genotypes and/or other populations.Genotype CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to chronicity.The majority of spontaneously cleared subjects(86%) were C/C,confirming its protective role.The C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of response.CMV reactivation occurred in 40% of CHC patients.Co-infection with CMV seriously diminished the response to interferon(IFN) therapy,with SVR rates in C/C genotypes 87.5% in CMV-negative patients and 12.5% in CMV-positive patients(P < 0.0001).SVR rates among C/T carriers were reduced to < 50% in patients with positive CMV DNA while the non-response rate doubled.These data indicate that a supplemental assay for CMV viremia adds to the prognostic value of IL28B genotyping.CONCLUSION:The results suggest that both genetic(i.e.,spontaneous) and therapeutic(IFN-based therapy) arms are complementary in the battle against HCV.CMV DNA testing may be of value to better predict the response to IFN,particularly in IL28B C/T carriers. | Mostafa K El Awady Noha G Bader El Din Ashraf Tabll Yaser El Hosary Ashraf O Abdel Aziz Hesham El Khayat Mohsen Salama Tawfeek H Abdelhafez | 2013 | World Journal of Gastroenterology2013，19，2： | 8 |
| 2 | Passive and active elementsusing fractional LβCαCircuit显示文摘 | RadwanA G salama K N | 2011 | IEEE Transaction onCircuit and Systems I:Regular Papers2011，58，10： | 1 |
| 3 | Evaluation of pleural CYFRA21-l and carcinoembryonic antigen in the dignosis of malignant pleural effusions显示文摘 | Salama G Miedouge M Rouzaud P | | 0，，03： | 1 |
| 4 | Malignant peripheral primitive neuroectodermal tumor-peripheral neuroepithelioma of the head and neck:a clinicopathologic study of five cases and review of the literature显示文摘 | Nikitakis N G Salama A R O'Malley B W | 2003 | Head Neck2003，25，6： | 1 |
| 5 | Transient and steady-state load performance of a stand-alone self-excited induction generator 显示文摘 | Salama M H Holmes P G | 1996 | IEE Proc Elec Power App1996，143，1： | 1 |
| 6 | Hepatitis C virus infected in French hemodialysis units: Amulti-center study 显示文摘 | Salama G Rostaing I Sandres K | 2006 | J Med Virol2006，61，： | 1 |
| 7 | Transient and steady-state load performance of a stand-alone self-excited induction generator显示文摘 | Salama M H Holmes P G | 1996 | IEE Proceedings Electric Power Applications1996，143，1： | 1 |
| 8 | Hepatitis C rirus infection in French hemodialysis units:A multi-center study显示文摘 | Salama G Rostaing I Sandres K | 2000 | J Med Virol2000，61，： | 1 |
| 9 | A randomized, blin- ded, controlled clinical study of particulate anorganic bovine bone mineral and catcium phosphosilicate putty bone substitutes for socket preservation显示文摘 | Kotsakis G A Salama M Chrepa V | 2014 | Int J Oral Maxillofac Implants2014，29，1： | 1 |
| 10 | An integrated distributed generation optimization model for distribution system planning 显示文摘 | EI-KHATTAM W HEGAZY Y G SALAMA M M A | 2005 | IEEE Transactions on Power Systems2005，20，2： | 1 |
| 11 | Uterine fibroids and current clinical challenges 显示文摘 | Salama S S Kdl G S | 2013 | J Turk Ger Gynecol Assoc2013，14，： | 1 |
| 12 | (1994) Basin geomerphological controls on the mechanism of rechargeand discharge and its effect on salt storage mobilization comparative study using geophysical surveys 显示文摘 | Salama R B Bartle G Farrigton P | 1994 | Journal of Hydrology1994，155，： | 1 |
| 13 | A CMOS bandgap voltage reference显示文摘 | Tzanateas G Salama C A T Tsividis Y P | 1979 | IEEE Sol Sta Circ1979，14，3： | 1 |
| 14 | Optimal placement of active/passive members in truss structures using simulated annealing显示文摘 | CHEN G S BRUNO R J SALAMA M | 1991 | AIAA Journal1991，29，： | 1 |
| 15 | Evaluation of seven tumor markers in pleural fluid for the diagnosis of m alignant ef- fusions 显示文摘 | Miedouge M Rouzaud P Salama G | 1999 | Br J Cancer1999，81，5： | 1 |
| 16 | Evaluation of seven tumour markers in pleural fluid for the diagnosis of malignant effu- sions显示文摘 | Mi6doug6 M Rouzaud P Salama G | 1999 | Br J Cancer1999，81，6： | 1 |
| 17 | Super-junction LDMOST on a silicon-on-sapphire substrate 显示文摘 | NASSIF-KHALIL S G SALAMA C A T | 2003 | IEEE Transaction Electron Devices2003，50，5： | 1 |
| 18 | Transient and steady-state load performance of a stand-alone self-excited induction generator显示文摘 | Salama M H Hohnes P G | 1996 | IEE Proceedings Electric Power Applications1996，143，1： | 1 |
| 19 | Mouse models of long-QT syndrome 显示文摘 | Salama G London B | 2007 | J Physiol2007，578，： | 1 |
| 20 | Evaluation of seven tumomarkers in pleural fluid for the diagnosis of malignant effusion 显示文摘 | Miedouge M Rouzaud P Salama G | 1999 | BrJ Cancer1999，81，6： | 1 |
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