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| 1 | Autologous CD34^+ and CD133^+ stem cells transplantation in patients with end stage liver disease显示文摘AIM:To assess the utility of an autologous CD34 + and CD133 + stem cells infusion as a possible therapeutic modality in patients with end-stage liver diseases.METHODS:One hundred and forty patients with endstage liver diseases were randomized into two groups.Group 1,comprising 90 patients,received granulocyte colony stimulating factor for five days followed by autologous CD34 + and CD133 + stem cell infusion in the portal vein.Group 2,comprising 50 patients,received regular liver treatment only and served as a control group.RESULTS:Near normalization of liver enzymes and improvement in synthetic function were observed in 54.5% of the group 1 patients;13.6% of the patients showed stable states in the infused group.None of the patients in the control group showed improvement.No adverse effects were noted.CONCLUSION:Our data showed that a CD34 + and CD133 + stem cells infusion can be used as supportive treatment for end-stage liver disease with satisfactory tolerability. | Hosny Salama Abdel-Rahman N Zekri Abeer A Bahnassy Eman Medhat Hanan A Halim Ola S Ahmed Ghada Mohamed Sheren A Al Alim Ghada M Sherif | 2010 | World Journal of Gastroenterology2010，16，42： | 16 |
| 2 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 3 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 4 | Passive and active elementsusing fractional LβCαCircuit显示文摘 | RadwanA G salama K N | 2011 | IEEE Transaction onCircuit and Systems I:Regular Papers2011，58，10： | 1 |
| 5 | N-termi- nal pro-BNP in acute coronary syndrome patients with ST eleva- tion (STE-ACS) versus non ST elevation (NSTE-ACS)显示文摘 | SALAMA R EL-MONIEM A EL-HEFNEY N | 2011 | Int J Health Sci2011，5，1： | 1 |
| 6 | Role of tigecycline in the control of a carbapenem-resistant Acinetobacter baumannii outbreak in an intensive care unit显示文摘 | Jamal W Salama M Dehrab N | 2009 | J Hosp Infect2009，72，3： | 1 |
| 7 | Trend in partial discharge pattern classification: a survey显示文摘 | Sahoo N C Salama M MA Bartnikas R | 2005 | IEEE Trans on Dielectrics and Electrical Insulation2005，12，2： | 1 |
| 8 | Regulatory functions of CD8^+CD28^- T cells in an autoimmune disease model显示文摘 | Najafian N Chitnis T Salama AD | 2003 | J Clin Invest2003，112，7： | 1 |
| 9 | Effects of expo- sure to a mobile phone on testicular function and structure in adult rabbit显示文摘 | Salama N Kishimoto T Kanayama H O | 2008 | Int J Andro2008，33，1： | 1 |
| 10 | Malignant peripheral primitive neuroectodermal tumor-peripheral neuroepithelioma of the head and neck:a clinicopathologic study of five cases and review of the literature显示文摘 | Nikitakis N G Salama A R O'Malley B W | 2003 | Head Neck2003，25，6： | 1 |
| 11 | Crystallization and properties of glasses based on diopside-Ca-Tschermak's-fluorapatite system显示文摘 | Samia N Salama H | 2005 | Journal of the European Ceramic Society2005，25，7： | 1 |
| 12 | N-TerminaL PRO-BNP in Acute Coronary Syndrome Patients with ST Elevation VersusNon ST Ele- vation in Qassim Region of Sandi Arabia显示文摘 | Salama RH E1-Moniem AE E1-Hefney N | 2011 | Int J Health Sci2011，5，2： | 1 |
| 13 | Lassification of capacitor allocation techniques 显示文摘 | NG H N SALAMA M M A CHIKHANI A Y | 2000 | IEEE Trans Power Delivery2000，15，1： | 1 |
| 14 | Trends in partial discharge pattern classification: a survey显示文摘 | SAHOO N C SALAMA M M A BARTNIKAS R | 2005 | IEEE Transactions on Dielectrics and Electrical Insulation2005，12，2： | 1 |
| 15 | CMOS Operational Transresistance Amplifier for Analog Signal Processing显示文摘 | Salama K N Soliman A M | 1999 | Microelectronics1999，30，2： | 1 |
| 16 | Mesenchymal stem cell content of human vertebral bone marrow 显示文摘 | Ahrens N Tormin A Paulus M Roosterman D Salama A Krenn V | 2004 | Transplantation2004，78，6： | 1 |
| 17 | Trends in partial discharge pattern classification:A survey显示文摘 | SAHOO N C SALAMA M M A BARTNIKAS R | 2005 | IEEE Transactions on Dielectrics and Electrical Insulation2005，12，2： | 1 |
| 18 | CMOS operational trans resistance amplifier for analog signal processing显示文摘 | Salama K N Soliman A M | 1999 | Microelectronics J1999，30，2： | 1 |
| 19 | Robust Fractional-Order Proportional-Integral Observer for Synchronization of Chaotic Fractional-Order Systems显示文摘In this paper, we propose a robust fractional-order proportional-integral(FOPI) observer for the synchronization of nonlinear fractional-order chaotic systems. The convergence of the observer is proved, and sufficient conditions are derived in terms of linear matrix inequalities(LMIs) approach by using an indirect Lyapunov method. The proposed FOPI observer is robust against Lipschitz additive nonlinear uncertainty. It is also compared to the fractional-order proportional(FOP) observer and its performance is illustrated through simulations done on the fractional-order chaotic Lorenz system. | Ibrahima N’Doye Khaled Nabil Salama Taous-Meriem Laleg-Kirati | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 1 |
| 20 | A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains显示文摘 | Salama N Guillemin K McDaniel TK | 2000 | Proc Natl Acad Sci USA2000，97，14： | 1 |
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