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| 1 | Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats显示文摘AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group.Rats in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 wk.Animals in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 wk.Rats in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn oil.Animals in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group 4.Rats in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group 4.RESULTS:Administration of DENA resulted in a significant increase in alanine transaminase(ALT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(ALP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver tissues.In the carnitine-depleted rat model,DENA induced a dramatic increase in serum ALT,G-GT,ALP and total bilirubin,as well as a progressive reduction in total carnitine content in liver tissues.Interestingly, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control values.Histopathological examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-induced hepatic damage. CONCLUSION:Data from this study suggest for the first time that:(1)carnitine deficiency is a risk factor and should be viewed as a mechanism in DENA- induced hepatic carcinogenesis;(2)oxidative stress plays an important role but is not the only cause of DENA-induced hepatic carcinogenesis;and(3) long-term L-carnitine supplementation prevents the development of DENA-induced liver cancer. | Salim S Al-Rejaie Abdulaziz M Aleisa Abdulaziz A Al-Yahya Saleh A Bakheet Abdulmalik Alsheikh Amal G Fatani Othman A Al-Shabanah Mohamed M Sayed-Ahmed | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 2 | Whole body imaging in blunt rnultisystern trauma patients without obvious signs of injury: results of a prospective study显示文摘 | Salim A Sangthong B Martin M el al | 2006 | Arch Surg2006，141，5： | 1 |
| 3 | Tube thorocostomy: management and outcome in patients with penetrating chest trauma显示文摘 | Muslim M Bilal A Salim M | 2008 | J Ayub Med Coil Ablmttabad2008，20，4： | 1 |
| 4 | An evaluation of tumor oxy- genation and gene expression in patients with early stage non-small cell lung cancers 显示文摘 | Le QT Chen E Salim A | 2006 | Clin Cancer Res2006，12，5： | 1 |
| 5 | Fabrication, fouling and foulant analyses of asymmetric polysulfone (PSF) ultra{iltration membrane fouled with natural or- ganic matter (NOM) source waters显示文摘 | Zularisam A W Ismail A F Salim M R | 2007 | Journal nf Mem- brane Science2007，299，97： | 1 |
| 6 | Indications for routine repeat head computed tomography (CT) stratified by severity of traumatic brain injury显示文摘 | Brown C V Zada G Salim A | | 0，，6： | 1 |
| 7 | Persistenthyperglycemia in severe traumatic brain injury:anindependent predictor of outcome显示文摘 | Salim A Hadjizacharia P Dubose J | 2009 | Am Surg2009，75，1： | 1 |
| 8 | The osteogenic potential of adipose-derived mesenchymal cells is maintained with aging显示文摘 | Shi Y Y Nacamuli R P Salim A | 2005 | Plast Re-constr Surg2005，116，16： | 1 |
| 9 | Plant-parasitic nematodes associated with Musa in Zanzibar显示文摘 | Rajab K A Salim S S Speijer P R | 1999 | African Plant Protection1999，5，2： | 1 |
| 10 | Angiogenesisisrequired for suc-cessful bone induction during distraction osteogenesis显示文摘 | Fang TD Salim A Xia W | 2005 | J Bone miner Res2005，20，7： | 1 |
| 11 | A review of the effects of emerging contaminants in wastewater and options for their removal显示文摘 | Bolong N Ismail A Salim M R | 2009 | Desalination2009，239，1： | 1 |
| 12 | Neuroblastoma:a 20-year experience in a UK regional centre显示文摘 | Salim A Mullassery D Pizer B | 2011 | Pediatr Blood Cancer2011，57，7： | 1 |
| 13 | Short,highly effective,and inexpensive standardized treatment of multidrugresistant tuberculosis显示文摘 | Van Deun A Maug AK Salim MA | | 0，，05： | 1 |
| 14 | Protection against stress-induced acute gastric mucosal injury by free radical scavengers显示文摘 | | 1991 | Intersive Care Med1991，17，8： | 1 |
| 15 | Oxidative stress: a potential recipe for anxiety, hypertension and insulin resistance显示文摘 | Salim S Asghar M Chugh G et a| | | Brain Res0，1359，： | 1 |
| 16 | Human biliverdin reductase is autophosphorylated,and phosphorylation is required for bilirubin formation显示文摘 | Salim M Brown-Kipphut B A Maines M D | 2001 | J Biol Chem2001，276，10： | 1 |
| 17 | The effects of natural organic matter ( NOM ) fractions on fouling characteristics and flux recovery of ultrafihration membranes 显示文摘 | ZULARISAM A W ISMAIL A F SALIM M R | 2007 | Desalination2007，212，： | 1 |
| 18 | Normal electrocardi- ography and serum troponin 1 levels preclude the presence of clini- cally significant blunt cardiac injury显示文摘 | Velhamos GC Karaiskakis M Salim A | 2003 | J Tranma2003，54，1： | 1 |
| 19 | Short, highly effective, and inexpensive standardized treatment of multidrug- resistant tuberculosis 显示文摘 | Van Deun A Maug AK Salim MA | 2010 | Am J Respir Crit Care Med2010，182，5： | 1 |
| 20 | Symptomatic cardiotoxicity with high-dose 5-fluorouracil infusion: a prospective study显示文摘 | Akhtar S S Salim K P Bano Z A | 1993 | Ontology1993，50，6： | 1 |
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