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| 1 | First isolation of glutinol and a bioactive fraction with good antiinflammatory activity from n-hexane fraction of Peltophorum africanum leaf显示文摘Objective: To investigate the anti-inflammatory activity of different fractions and glutinol(isolated compound),using nitric oxide synthase and cyclooxygenase(COX) inhibition as an indication of anti-inflammatory activity,Methods: Anti-inflammatory activity was evaluated using an in vitro assay determining the inhibition of the activity of pro-inflammatory enzyme model,Cyclooxygenases and inducible nitric oxide synthase are crucial enzymes involved in the pathogenesis of many chronic inflammatory conditions,Results: Sub-fraction F3.3 that was derived from n-hexane fraction of PA leaves significantly inhibited(P = 0.01) the catalytic activity of COX-2(IC50 = 0.67 μg/m L) better than isolated compound,glutinol(IC50 = 1.22 μg/m L),compound 2(CP2)(IC50 = 1.71 μg/m L) and sub-fraction F3.3.0(IC50 = 1.30 μg/m L),A similar trend was observed in investigation of the inhibition of nitric oxide synthesis in RAW 264.7 cells by F3.3,glutinol,CP2 and F3.3.0,Inducible COX-2 and inducible nitric oxide synthase are among potent signalling enzymes that exacerbate inflammation,Conclusions: Bioactive sub-fractions(F3.3 and F3.3.0) derived from the n-hexane fraction of PA had good anti-inflammatory activity,and the isolated compound,and glutinol may be useful as a template for the development of new anti-inflammatory drugs. | Salmon A Adebayo Leshweni J Shai Jacobus N Eloff | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，1： | 2 |
| 2 | Gene delivery to the myocardium by intrapericardial injection 显示文摘 | Fromes Y Salmon A Wang X | 1999 | Gene Ther1999，6，4： | 1 |
| 3 | PROOF study Group 显示文摘 | Chesnut CH Silveman S Andviano k A vandomized tial of nasal spay salmon calcitonin in postmenopausal women with established osteporosis: the prevnt recurrence of osteoporasis farcture study | 2000 | Am J Med2000，109，6： | 1 |
| 4 | Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation显示文摘 | P0ZDZIK A SALMON U DEBELLE FD | 2008 | Kidney Int2008，73，5： | 1 |
| 5 | The spindle-assembly checkpoint in space and time显示文摘 | Musacchio A Salmon ED | 2007 | Nat Bev Mol Cell Biol2007，8，5： | 1 |
| 6 | Gene delivery to the myocardium by intrapericardial injection显示文摘 | Fromes Y Salmon A Wang X | 1999 | Gene Ther1999，6，： | 1 |
| 7 | Synthesis, Charac- terization and Separation Properties of a Composite Mordenite/ ZSM-5/Chabazite Hydrophilic Membrane显示文摘 | Piera E Salmon M A Coronas J | 1998 | J Membr Sci1998，149，1： | 1 |
| 8 | Platelets in the syn- ovial fluid of patients with rheumatoid arthritis 显示文摘 | Farr M Wainwright A Salmon M | 1984 | Rheumatol Int1984，4，1： | 1 |
| 9 | Radiological landmarks for placement of the tunnels in single-bundle reconstruction of the anterior cruciate ligament显示文摘 | PINCZEWSKI L A SALMON L J JACKSON W F | | 0，，02： | 1 |
| 10 | Phylogenetic analysis of the vertebrate glycoprotein hormone family including new sequences of sturgeon (Acipenser baeri) β subunits of the two gonadotropins and the thyroid-stimulating hormone显示文摘 | Quérat B Sellouk A Salmon C | | 0，，01： | 1 |
| 11 | A five year comparison of patellar tendon versus four stand hamstring tendon autograft for arthroscopic reconstruction of anterior cruciate ligament显示文摘 | Pinczewski L A Deehan D J Salmon L J | | 0，，04： | 1 |
| 12 | Phylogcnelic analysis of the vertebrate glycoprotein hormonc family including new se quences of sturgeon (Acipezser t:aeri) beta subunits of thc two gonadotropins anti the thyroid stimulating hormone 显示文摘 | Qucrat B Sellouk A Salmon C | 2000 | Biology of Reproduc*ion2000，63，1： | 1 |
| 13 | Surgical management of post-traumatic angle recession glaucoma显示文摘 | Mermoud A Salmon JF Barron A | 1993 | Ophthalmology1993，100，5： | 1 |
| 14 | Full scale testing of precast concrete sandwich panels 显示文摘 | Salmon D C Einea A Tadors M K | 1997 | ACI Structure Journal1997，94，4： | 1 |
| 15 | Correlates of sedentary behaviours in preschool children:a review显示文摘 | Hinkley T Salmon J Okely A D Trost S G | 2010 | The international Journal of behavioral nutrition and physical activity2010，7，： | 1 |
| 16 | Post-traumatic angle recession glaucoma:a risk factor for bleb failure after trabeculectomy显示文摘 | Mermoud A Salmon JF Straker C | 1993 | Br J Ophthalmol1993，77，10： | 1 |
| 17 | Gene edlivery to the myocardium by intrapericardial injection显示文摘 | Fromes Y Salmon A Wang X | 1999 | Gene Ther1999，6，： | 1 |
| 18 | Trabeculectomy with mitomycin C for refractory glaucomain blacks显示文摘 | Mermoud A Salmon JF Murray AD | 1993 | Am J Ophthalmol1993，116，： | 1 |
| 19 | Partially Composite Sandwich Panel Deflection显示文摘 | Salmon D C Einea A | 1995 | ASCE Journal of structural Engineering1995，121，4： | 1 |
| 20 | Trabeculectomy with mitomycin C in the treatment of post-traumatic angle recession glaucoma显示文摘 | Manners T Salmon JF Barron A | 2001 | Br J Ophthalmol2001，85，2： | 1 |
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