|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes显示文摘Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI. | Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose Manuel Vázquez-Rodríguez Maria López-Benito Felipe Fernández-Vázquez | 2014 | World Journal of Cardiology2014，6，6： | 6 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Diagnostic yield and clinical outcomes after capsule endoscopy in 100 consecutive patients with obscure gastrointestinal bleeding显示文摘 | Emilio Estévez Benito González-Conde José Luis Vázquez-Iglesias Maria de los Angeles Vázquez-Millán Sonia Pértega Pedro A. Alonso Joan Clofent Eva Santos José Luis Ulla Eloy Sánchez | 2006 | European Journal of Gastroenterology & Hepatology2006，，8： | 3 |
| 4 | Mechanical properties of HSLA bainitic steel subjected to controlled rolling with accelerated cooling显示文摘 | RODRIGUES P C M PERELOMA E V SANTOS D B | 2000 | Materials Science and Engineering: A2000，283，： | 1 |
| 5 | Vascular en- dothelia~ growth factor expression in the urethral epithelium of castrated adult female rats treated with tamoxifen显示文摘 | Dos Santos A R Lopes-Costa P V da Silva B B | 2009 | Gynecol Endocrinol2009，25，5： | 1 |
| 6 | Oxidation of CO,ethanol and toluene over TiO2 supported noble metal catalysts显示文摘 | SANTOS V P CARABINEIRO S A C TAVARES P B PEREIRA M F R ORFAO J J M FIGUEIREDO J L | | 0，，： | 1 |
| 7 | Thermally induced threefold upconversion emission enhancement in nonresonant excited Er^3+/Yb^3+-codoped chalcogenide glass显示文摘 | dos SANTOS P V GOUVEIA E A de ARAUJO M T | 1999 | Appl Phys Lett1999，74，24： | 1 |
| 8 | Hydrogen diffusion in Fe40Ni38Mo4B18 amorphous metallic alloys显示文摘 | dos SANTOS D S de MIRANDA P E V | 2003 | J Alloys Comp2003，348，： | 1 |
| 9 | Optical temperature sensing Using upconversion fluorescence emission in Er^3+/Yb^3+-codoped chalcogenide glass显示文摘 | dos SANTOS P V de ARAUJO M T GOUVEIA-NETO A S | 1998 | Appl Phys Lett1998，73，5： | 1 |
| 10 | Mechanical properties of an HSLA bainitic steel subjected to controlled rolling with accelerated cooling 显示文摘 | Pereloma E V Santos D B | 2000 | Mater Sci Eng2000，283，： | 1 |
| 11 | Growth of polycrystalline silicon on glass by selective laser -induced nucleation 显示文摘 | Toet D Koopmans B Santos P V | 1996 | Appl Phys Lett1996，69，24： | 1 |
| 12 | A randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid显示文摘 | SANTOS V N LANZONI V P SZEINFELS J | 2003 | Braz J Med Biol Res2003，36，6： | 1 |
| 13 | Gait transition and modula- tion in a quadruped robot: A brainstem-like modula- tion approach 显示文摘 | SANTOS C P MATOS V | 2011 | Robotics and Autonomous Systems2011，59，9： | 1 |
| 14 | Mechanical properities of an HSLA bainitic steel subjected to controlled rolling with accelerated cooling显示文摘 | Rodrigues P C M Pereloma E V Santos D B | 2000 | Mater Sci Eng2000，283，： | 1 |
| 15 | The renin-angiotensin system in a rat model of hepatic fibrosis: evidence for a protective role of Angiotensin-(1-7) 显示文摘 | Pereira R M Dos Santos R A Teixeira M M Leite V H Costa L P da Costa Dias F L | 2007 | J Hepatol2007，46，： | 1 |
| 16 | Carbon tetramhloride hydrodechlorination with organometallics-based platinum arid palladium catalysts on MgO显示文摘 | Santo V D Dossi C Cloavita P E | 2002 | J Mol Catal A2002，，： | 1 |
| 17 | Bose-Einstein Condensation in Trapped Dipolar Gases显示文摘 | SANTOS L SHLYAPNIKOV G V ZOLLER P LEWENSTEIN M | 2000 | Phys Rev Lett2000，85，： | 1 |
| 18 | Mechanical Properties of an HSLA Bainitic Steel Subjected to Con- trolled Rolling with Accelerated Cooling显示文摘 | Rodrlgues P C M Pereloma E V Santos D B | 2000 | Materials Sci- ence and Engineering2000，283，： | 1 |
| 19 | Safety impli- cations of culture and cognitive issues in nuclear power plant operation 显示文摘 | Carvalho P V R Santos I L D Vidal M C R | 2006 | Applied Ergonomics2006，37，2： | 1 |
| 20 | Fish off-flavor analysis by headspace and off-line purgeand-trap followed by HRGC-MS显示文摘 | Santos G V Da Cunha Veloso M C De Paula Pereira P A | 2001 | American Laboratory2001，33，24： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员