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| 1 | 无针喷注器注射博来霉素治疗瘢痕疙瘩和肥厚性瘢痕的一项初步研究显示文摘Background: Numerous treatment modalities have been used to treat keloids and hypertrophic scars, but the optimal treatment has not been established. Objectiv e: The aim of this study was to determine the efficacy and safety of intralesion al jet injection of bleomycin as therapy for keloids and hypertrophic scars that are unresponsive to intralesional steroid injection. Methods: The study include d 14 patients with 15 keloids or hypertrophic scars that had not responded to a minimum of three intralesional injections of triamcinolone acetonide. Multiple j et injections of 0.1 ml of bleomycin (1.5 IU/ml) were administered to each lesio n, with injection sites spaced 0.5 mm apart. Injections were repeated each month . Scar height was measured, and scar pliability and erythema were scored at base line and then monthly during the treatment and followup periods. Patients’self -assessments of subjective symptoms (pruritus and pain)were also scored. Clinic al improvementwas defined primarily on the basis of scar height reduction (perce ntage reduction from baseline), and was classified using the following scale: co mplete flattening (100%), highly significant flattening (> 90%), significant f lattening (75-90%), moderate flattening (50-75%), and minimal flattening (< 50%). Preand post-treatment mean values for scar height, scar pliability, eryt hema, pruritus and pain were statistically compared. Results: The number of sess ions required to successfully treat the lesions ranged from two to six. Eleven l esions (73.3%) showed complete flattening, one (6.7%) showed highly significan t flattening, two (13.3%) showed significant flattening, and one scar (6.7%) s howed moderate flattening. The mean scar height was significantly lower, and the mean scores for scar pliability and erythema were significantly better at the e nd of treatment (P < 0.001, P < 0.001 and P < 0.001, respectively). The mean sco res for pruritus and pain also improved significantly (P < 0.001 and P=0.01, res pectively). The observed side-effects were hyperpigmentation (four lesions) and skin atrophy (three lesions). No recurrences were noted during follow up (mean duration of 19 months). Conclusions: Intralesional jet injection of bleo mycin is an effective and safe method of treating keloids and hypertrophic scars that are unresponsive to intralesional steroid therapy. | Saray Y GüleT 冯义国 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，1： | 2 |
| 2 | Antigenic properties of porcine teschovirus 1 (PTV-1) Talfan strain and molecular strat- egy for serotyping of PTVs 显示文摘 | Kaku Y Murakami Y Sarai A | 2007 | Arch Virol2007，152，5： | 1 |
| 3 | Genetic reclassification of porcine enteroviruses 显示文摘 | Kaku Y Sarai A Murakami Y | 2001 | J Gen Virol2001，82，2： | 1 |
| 4 | Genetic reclassi- fication of porcine enteroviruses 显示文摘 | KAKU Y SARAI A MURAKAMI Y | 2001 | J Gen Virol2001，82，： | 1 |
| 5 | Reinduction of T-type calcium channels by endothelin-1 in failing hearts in vivo and in adult rat ventricular myocytes in vitro 显示文摘 | IZUMI T KIHARA Y SARAI N | 2003 | Circulation2003，108，20： | 1 |
| 6 | Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study显示文摘 | Saray Y Gulec AT | 2005 | Int J Dermatol2005，44，9： | 1 |
| 7 | Tissue angiotensin II during pro- gression or ventrlcular hypertrophy to heart failure in hypertensive rats; diferential effects on PKC epsilon and PKC beta显示文摘 | Inagaki K Lwanaga Y Sarai N | 2002 | J Mol Cell Cardi- ol2002，34，10： | 1 |
| 8 | Unique mode of GCC box recognition by the DNA-binding domain of ethylene-responsive element-binding factor (ERF domain) in plant 显示文摘 | Hao D Y Ohme-Takagi M Sarai A | 1998 | J Biol Chem1998，273，26： | 1 |
| 9 | Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin:a preliminary study显示文摘 | SARAY Y GULEC A T | 2005 | Int J Dermatol2005，44，9： | 1 |
| 10 | Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta显示文摘 | Inagaki K Iwanaga Y Sarai N | 2002 | J Mol Cell Cardiol2002，34，10： | 1 |
| 11 | A parametric study on natural gas fueled HCCI combustion engine using a multi-zone combustion model显示文摘 | NOBAKHT A Y SARAY R K RAHIMI A | 2011 | Fuel2011，90，： | 1 |
| 12 | Familial aquagenic acrokeratoderma: case repoets and review of the literature显示文摘 | Saray Y Sehikin D | 2005 | Int J Derma tol2005，44，11： | 1 |
| 13 | Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats,differential effects on PKCε and PKCβ显示文摘 | Inagaki K Iwanaga Y Sarai N | 2002 | J Mel Cell Cardiol2002，34，： | 1 |
| 14 | Acquired perforating dermatosis:clinicopathological features in twenty two ea- ses 显示文摘 | Saray Y Seqchkin D Bilezikqi B | 2006 | J Eur Acad Dermatol Venereol2006，20，6： | 1 |
| 15 | The cavity in the hydrophobic core of Myb DNA-binding domain is reserved for DNA recognition and trans-activation显示文摘 | Ogata K Kanei-Ishii C Sasaki M Hatanaka H Nagadoi A Enari M Nakamura H Nishimura Y Ishii S and Sarai A | | 0，，02： | 1 |
| 16 | Solution structure of a DNA-binding unit of Myb: ahelix-turn-helix-related motif with conserved tryptophans forming ahydrophobic core 显示文摘 | Ogata K Hojo H Aimoto S Nakai T Nakamura H Sarai A IshiiS Nishimura Y | 1992 | Proc Natl Acad Sci USA1992，89，14： | 1 |
| 17 | Genetic reclassifi- cation of porcine enteroviruses 显示文摘 | Kaku Y Sarai A Murakami Y | 2001 | J Gen Virol2001，82，2： | 1 |
| 18 | Antigenic properties of porcine teschovirus 1 (PTV-1) Talfan strain and molecular strategy for serotyping of PTVs 显示文摘 | Kaku Y Murakami Y Sarai A | 2007 | Arch Virol2007，152，： | 1 |
| 19 | Genetic reclassification of porcine enteroviruses显示文摘 | Kaku Y Sarai A Murakami Y | | 0，，： | 1 |
| 20 | Antigenic properties of Porcine teschovirus 1(PTV-1) Talfan strain and molecular strategy for seretyping of PTVs显示文摘 | KAKU Y MURAKAMI Y SARAI A | 2007 | Arch Virol2007，152，5： | 1 |
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