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| 1 | Analysis of the delayed approach to the management of infected pancreatic necrosis显示文摘AIM: To analyze outcomes of delayed single-stage necrosectomy after early conservative management of patients with infected pancreatic necrosis (IPN) associated with severe acute pancreatitis (SAP). METHODS: Between January 1998 and December 2009, data from patients with SAP who developed IPN and were managed by pancreatic necrosectomy were analyzed. RESULTS: Fifty-nine of 61 pancreatic necrosectomies were performed by open surgery and 2 laparoscopically. In 55 patients, single-stage necrosectomy could be performed (90.2%). Patients underwent surgery at a median of 29 d (range 13-46 d) after diagnosis of acute pancreatitis. Sepsis and multiple organ failure accounted for the 9.8% mortality rate. Pancreatic fistulae (50.8%) predominantly accounted for the morbidity. The median hospital stay was 23 d, and the median interval for return to regular activities was 110 d.CONCLUSION: This series supports the concept of delayed single-stage open pancreatic necrosectomy for IPN. Advances in critical care, antibiotics and interventional radiology have played complementary role in improving the outcomes. | Nilesh Doctor Sujith Philip Vidhyachandra Gandhi Maharra Hussain Savio G Barreto | 2011 | World Journal of Gastroenterology2011，17，3： | 15 |
| 2 | Extended pancreatic resections and lymphadenectomy:An appraisal of the current evidence显示文摘Surgery remains the mainstay of treatment for pancreatic ductal adenocarcinoma and complete removal of the cancer confers a definite survival advantage,especially in early disease.However,the majority of patients do not present with early disease,thus precluding the chance of a cure by standard pancreatoduodenectomy(PD),distal pancreatectomy or total pancreatectomy.For this reason,pancreatic surgeons have attempted to push the limits of resection over the last three decades.The aim of these resections has been to determine whether obtaining a complete resection by extending the limits of conventional resection in patients with advanced disease will yield the results seen with PD alone in early disease.This article revisits the data from such studies in an attempt to determine if the available literature supports the performance of extended resections for pancreatic cancer in terms of improvement of survival. | Shailesh V Shrikhande Savio G Barreto | 2010 | World Journal of Gastrointestinal Surgery2010，2，2： | 2 |
| 3 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 4 | Surgery for gallbladder cancer:The need to generate greater evidence显示文摘The outcomes for gallbladder cancer remain largely dismal to this day.Overall,the low incidence of gallbladder cancer around the world coupled with an even lower number of patients amenable to surgery at the time of presentation,has precluded the generation of evidence-based guidelines for the management of this cancer.However,while the incidence of the cancer may be decreasing in some parts of the world,in other countries such as India,Japan and Chile,gallbladder cancer continues to affect a sizeable population of patients.As such,there is a growing need to define what constitutes an adequate surgery for each stage of this cancer,based on sound evidence.This editorial provides a broad overview of the existing problems in the management of gallbladder cancer and appeals for multi-institutional studies aimed at answering some of the pertinent questions on the surgical management of gallbladder cancer. | Shailesh V Shrikhande Savio G Barreto | 2009 | World Journal of Gastrointestinal Surgery2009，1，1： | 2 |
| 5 | Charaeterrisation of gastric Ghrelin cells in man and other mammals: syudies in adult and fetal tissues显示文摘 | Rindi G Necchi V Savio A | 2002 | Histochem Cell Biol2002，117，： | 1 |
| 6 | Steady state responses to multiple amplitude-modulated tones:an optimized method to test frequency-specific thresholds in hearing-impaired children and normal-hearing subjects显示文摘 | Perez-Abalo MC Savio G Torres A | 2001 | Ear Hear2001，22，3： | 1 |
| 7 | Treatment of metastatic breast cancer with vinorelbine and docetaxel显示文摘 | Savio G Laudani A Leonardi V | 2006 | Am J Clin Oncol2006，29，3： | 1 |
| 8 | Diagnosis and posttreatment follow-up of Helicobacter pylori-positive -gastric lymphoma of mucosa-associated lymphoid tissue-histology, polymerase chain reaction, or both 显示文摘 | Savio A Franzia G Wotherspoon AL | 1996 | Blood1996，87，： | 1 |
| 9 | Diagnosis and posttreatment follow-up of helicobacter pylori-positive gastric lymphoma of mucosa-associated lymphoid tissue:histology,polymerase chain reaction,or both?显示文摘 | Franzin G Wotherspoon AC | 1996 | Blood1996，87，4： | 1 |
| 10 | Progressive lens design by discrete shape modelling techniques显示文摘 | Savio G Concheri G Meneghello R | 2013 | Springer2013，7，： | 1 |
| 11 | Inhibition of mammalian DNA polymerases by Resveratrol:mechanism and structural determinants显示文摘 | Locatelli G A Savio M Forti L | 2005 | Biochem J2005，389，2： | 1 |
| 12 | Steady state responses to multiple amplitude-modulated tones: an optimized method to test frequency-specific thresholds in hearing-impaired children and nomal-hearing subjects显示文摘 | Pere-Abalo MC Savio G Torres A | 2001 | Ear Hear2001，22，4： | 1 |
| 13 | Steady state responses to multiple amplitude-modulated tones: an optimized method to test frequency-specific thresholds in hearing-impaired children and normal-hearing subjects显示文摘 | Perez-Abalo MC Savio G Tm-res A | 2001 | Ear Hear2001，22，3： | 1 |
| 14 | The low and high frequency auditory steady-state responses mature at different rates显示文摘 | Savio G Cardenas J Perez-Abalo M | 2001 | Audiology and Neuro-otology2001，6，3： | 1 |
| 15 | Submillimeter Accuracy of InSAR Time Series: Experimental Validation显示文摘 | Ferrettl A Savio G Barzaghi R | 2007 | 1EEE Transactions on Geoscience and Remote Sensing2007，45，5： | 1 |
| 16 | Steady state responses to multiple amplitude-modulated tones:an optimized method to test frequency-specific thresholds in hearing-impaired children and normal-hearing subjects显示文摘 | Perez-Abalo MC Savio G Torres A | 2001 | Ear Hear2001，22，： | 1 |
| 17 | New approaches to breast cancer combined with 5-fluorouracil and folinic acid in pretreated advanced breast cancer patients:preliminary reports 显示文摘 | Leonardi V Savio G Laudani A | 2002 | Ann N Y Acad Sci2002，963，6： | 1 |
| 18 | Staedy state reponses to multiple amplitude-modulated tones:an optimized method to test frequency-specific thresholds in hearing-impaired children and normal-hearing subjects显示文摘 | Perez-Abalo MC Savio G Torres A | 2001 | Ear Hear2001，22，： | 1 |
| 19 | Steady state responses to multiple amplitude-modulated tones: an optimized method to test frequency-specific thresholds in heating-impaired children and normal-heating subjects 显示文摘 | Perez-Abalo MC Savio G Tones A | 2001 | Ear Hear2001，22，3： | 1 |
| 20 | An integrated methodology for the functional design of dental prosthesis 显示文摘 | Meneghello R Savio G Raffaeli R | 2013 | int J Interact Des Manuf2013，7，2： | 1 |
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