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| 1 | Clinical trial:Lactobacillus plantarum 299v(DSM 9843)improves symptoms of irritable bowel syndrome显示文摘AIM:To assess the symptomatic efficacy of Lactobacillus plantarum 299v(L.plantarum 299v)(DSM 9843) for the relief of abdominal symptoms in a large subset of irritable bowel syndrome(IBS) patients fulfilling the Rome Ⅲ criteria.METHODS:In this double blind,placebo-controlled,parallel-designed study,subjects were randomized to daily receive either one capsule of L.plantarum 299v(DSM 9843) or placebo for 4 wk.Frequency and intensity of abdominal pain,bloating and feeling of incomplete rectal emptying were assessed weekly on a visual analogue scale while stool frequency was calculated.RESULTS:Two hundred and fourteen IBS patients were recruited.After 4 wk,both pain severity(0.68 + 0.53 vs 0.92 + 0.57,P < 0.05) and daily frequency(1.01 + 0.77 vs 1.71 + 0.93,P < 0.05) were lower with L.plantarum 299v(DSM 9843) than with placebo.Similar results were obtained for bloating.At week 4,78.1 % of the patients scored the L.plantarum 299v(DSM 9843) symptomatic effect as excellent or good vs only 8.1 % for placebo(P < 0.01).CONCLUSION:A 4-wk treatment with L.plantarum 299v(DSM 9843) provided effective symptom relief,particularly of abdominal pain and bloating,in IBS patients fulfilling the Rome Ⅲ criteria. | Philippe Ducrotté Prabha Sawant Venkataraman Jayanthi | 2012 | World Journal of Gastroenterology2012，18，30： | 17 |
| 2 | Management of pregnancy in Crigler Najjar syndrome type 2显示文摘Crigler Najjar syndrome is associated with indirect hyperbilirubinemia due to a deficiency of enzyme Uridine Di Phospho Glucoronosyl Transferase(UDPGT).Presented here is a case of a female in the first trimester of pregnancy,who was diagnosed to have type 2 Crigler Najjar syndrome.We also discuss the management of this rare disease especially in pregnancy.Unconjugated bilirubin can cross the placental barrier causing neuro-logical damage in the newborn.Patient was carefully monitored during pregnancy and treatment with pheno-barbitone in low doses was adjusted such that the serum bilirubin levels were below 10 mg/d L.Crigler Najjar syndrome being rare needs to be diagnosed early in pregnancy to avoid adverse fetal outcomes.Phenobarbitone being an inducer of enzyme UDPGT is used as the first line of treatment and is not teratogenic in the low doses used.Treatment protocol followed was on the basis of previous reported cases and successful perinatal outcome was achieved. | Alisha Nitin Chaubal Ruchir Patel Dhaval Choksi Kaivan Shah Meghraj Ingle Prabha Sawant | 2016 | World Journal of Hepatology2016，8，11： | 4 |
| 3 | Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer显示文摘Epidermal growth factor receptor(EGFR) has been an attractive target for treatment of epithelial cancers, including colorectal cancer(CRC). Evidence from clinical trials indicates that cetuximab and panitumumab(antiEGFR monoclonal antibodies) have clinical activity in patients with metastatic CRC. The discovery of intrinsic EGFR blockade resistance in Kirsten RAS(KRAS)-mutant patients led to the restriction of anti-EGFR antibodies to KRAS wild-type patients by Food and Drug Administration and European Medicine Agency. Studies have since focused on the evaluation of biomarkers to identify appropriate patient populations that may benefit from EGFR blockade. Accumulating evidence suggests that patients with mutations in EGFR downstream signaling pathways including KRAS, BRAF, PIK3CA and PTEN could be intrinsically resistant to EGFR blockade. Recent whole genome studies also suggest that dynamic alterations in signaling pathways downstream of EGFR leads to distinct oncogenic signatures and subclones which might have some impact on emerging resistance in KRAS wild-type patients. While anti-EGFR monoclonal antibodies have a clear potential in the management of a subset of patients with metastatic CRC, further studies are warranted to uncover exact mechanisms related to acquired resistance to EGFR blockade. | Zain A Sobani Ashwin Sawant Mikram Jafri Amit Keith Correa Ibrahim Halil Sahin | 2016 | World Journal of Clinical Oncology2016，7，5： | 3 |
| 4 | Superior safety of direct oral anticoagulants compared to Warfarin in patients with atrial fibrillation and underlying cancer: a national veterans affairs database study显示文摘Background Studies evaluating safety of warfarin and direct oral anticoagulants(DOACs) for prevention of stroke in patients with atrial fibrillation(AF) are lacking. Methods & Results All patients(n = 196,521) receiving care at veteran’s affairs with active cancer and AF from 2010–2015 were included. One-year mortality was significantly higher in unadjusted analysis with warfarin(44.9%) compared to dabigatran(25%, P < 0.001), rivaroxaban(24.4%, P < 0.001) and apixaban(30%, P < 0.001) and after adjusting for age, sex and type of cancer mortality(OR = 2.66, 95% CI: 2.52–2.82, P < 0.001). Risk of ischemic stroke(13.5% vs. 11.1%, 12.0%, 14.0%) was similar, however risk of hemorrhagic stroke was significantly higher among patients receiving warfarin(1.2%) compared to patients receiving dabigatran(0.5%), rivaroxaban(0.7%) and apixaban(0.8%) respectively, P = 0.04. Conclusions We demonstrated the superior safety profile of DOACs compared to warfarin among patients with underlying cancer and AF. Warfarin was associated with higher mortality, similar ischemic stroke risk but higher risk of hemorrhagic stroke. | Abhishek C Sawant Arnav Kumar Wilmon Mccray Sheldon Tetewsky Linda Parone Srilekha Sridhara Meghana Prakash Hiriyur Prakash Gary Tse Tong LIU Nidhi Kanwar Aishwarya Bhardwaj Sahoor Khan Christopher Manion Ankush Lahoti Ashish Pershad Peter Elkin John Corbelli | 2019 | Journal of Geriatric Cardiology2019，16，9： | 2 |
| 5 | On COVID-19-safety ranking of seats in intercontinental commercial aircrafts:A preliminary multiphysics computational perspective显示文摘The evolution of coronavirus disease(COVID-19)into a pandemic has severely hampered the usage of public transit systems.In a post-COVID-19 world,we may see an increased reliance on autonomous cars and personal rapid transit(PRT)systems,with inherent physical distancing,over buses,trains and aircraft for intracity,intercity,and interstate travel.However,air travel would continue to be the dominant mode of intercontinental transportation for humans.In this study,we perform a comprehensive computational analysis,using ANSYS Fluent,of typical intercontinental aircraft ventilation systems to determine the seat where environmental factors are most conducive to human comfort with regards to air quality,protection from orally or nasally released pollutants such as CO_(2)and coronavirus,and thermal comfort levels.Air velocity,temperature,and air pollutant concentration emitted from the nose/mouth of fellow travelers are considered for both Boeing and Airbus planes.In each plane,first class,business class,and economy class sections were analyzed.We present conclusions as to which is the optimum seat in each section of each plane and provide the data of the environmental conditions to support our inferences.The findings may be used by the general public to decide which seat to occupy for their next intercontinental flight.Alternatively,the commercial airliners can use such a model to plan the occupancy of the aircraft on long-duration intercontinental flights(viz.,Airbus A380 and Boeing B747). | Prathamesh S.Desai Nihar Sawant Andrew Keene | 2021 | Building Simulation2021，14，6： | 2 |
| 6 | Primary and secondary carbonaceous species in the atmosphere of Western Riverside County, California显示文摘 | Kwangsam Na Aniket A. Sawant Chen Song David R. Cocker | 2003 | Atmospheric Environment2003，，9： | 2 |
| 7 | Primary and secondary carbonaceous species in the atmosphere of Western Riverside County, California显示文摘 | Kwangsam Na Aniket A. Sawant Chen Song David R. Cocker | 2003 | Atmospheric Environment2003，，9： | 2 |
| 8 | Effects of base analogues 5-bromouracil and 6-aminopurine on development of zebrafish Danio Rerio显示文摘Zebrafish (Danio rerio) genetic screens allow isolation of a wide array of problems in vertebrate biology. The effects of base analogues 5-bromouracil and 6-aminopurine on the development of zebrafish embryos are reported for the first time in this study. The early development of the zebrafish embryos was little affected by 5-bromouracil and 6-aminopurine, while the late development (organogenesis) was significantly impaired. Embryos exposed to 5-bromouracil mainly showed curled tail, wavy body, golden pigmentation and the mouth with protruding lower jaw. 6-aminopurine-treated embryos had defective anterior structures, curled tails and wavy body. RAPD analysis showed that the majority of 5-bromouracil- and 6-aminopurine-treated larvae and fish shared banding patterns in common with the control, suggesting that most mutagenesis induced by these agents are point mutations. However, some fish derived from 5-bromouracil-treated embryos had golden (gol) pigmentation; and RAPD analysis revealed that their band patterns differed from those of the control. Possibly, 5-bromouracil can occasionally cause relatively extensive changes in the fish genome. The results of this study may provide valuable help for detailed studies of mutagenesis. | SAWANT M. S. 张士璀 王清印 | 2005 | Chinese Journal of Oceanology and Limnology2005，23，1： | 2 |
| 9 | Comparative analysis of genetic diversity among Indian populations of Scirpophaga incertulas by ISSR-PCR and RAPD-PCR显示文摘 | Kumar L S Sawant A S Gupta V S | 2001 | Biochem Genet2001，39，： | 1 |
| 10 | Photocatalytic and photochemical degradation of nitrobenzene using artificial ultraviolet light 显示文摘 | Bhatkhande D S Kamble S P Sawant S B | 2004 | Chemical Engineering Journal2004，102，3： | 1 |
| 11 | Se- quence architecture downstream of the initiator codon enhances gene expression and protein stability in plants 显示文摘 | SAWANT S V KIRAN K SINGH P K | 2001 | Plant Physiology2001，126，4： | 1 |
| 12 | A novel strategy towards the atorvastatin lactone显示文摘 | Sawant P Maier M E | 2010 | Tetrahedron2010，66，： | 1 |
| 13 | Evaluation of the use of monoclonal antibodies and nested PCR for noninvasive prenatal diagnosis of hemoglobinopathies in India显示文摘 | D′Souza E Sawant PM Nadkarni AH | 2008 | Am J Clin Pathol2008，130，86： | 1 |
| 14 | Removal of herbicide from water with sodium chloride using surfactant treated alumina for wastewater treatment 显示文摘 | Gawade A S Vanjara A K Sawant M R | 2004 | Separation and Purification Technology2004，21，： | 1 |
| 15 | Permeation of single gases in thin zeolite MFI membranes显示文摘 | Netke S A Sawant A B Joshi J B ct al | 1995 | J Membr Sci1995，107，： | 1 |
| 16 | Androgenetic alopecia: quality-of-life and associated lifestyle patterns显示文摘 | Sawant N Chikhalkar S Mehta V | 2010 | Int J Trichology2010，2，2： | 1 |
| 17 | Liquid-phase catalytic hydrogenation of p-chlorobenzophenone to p-chlorobenzhydrol over a 5% Pd/C catalyst 显示文摘 | Sunil P Bawane Sudhirprakash B Sawant | 2004 | Chem Eng Technol2004，27，8： | 1 |
| 18 | Valgus knee injuries : e- valuation and documentation using a simple technique of stress ra- diography 显示文摘 | Sawant M Narasimba Murty A Ireland J | 2004 | Knee2004，11，1： | 1 |
| 19 | Hydrogenation of p-nitrophenol to metol using Raney nickel catalyst: reaction kinetics 显示文摘 | Bawane S P Sawant S B | 2005 | Appl Catal A-Gen2005，293，： | 1 |
| 20 | Methylene blue dye iniection for identification of occult gastrointestinal bleeding显示文摘 | D' Mello A Sawant A D Kulkarni A | 2014 | Indian J Gastroenterol2014，33，1： | 1 |
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