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    题名 作者 年代 出处 被引量
1儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 2012中华高血压杂志2012,20,1:6
2急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR 2016中华高血压杂志2016,24,8:4
3一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) 2009世界临床医学2009,,9:2
4A novel TNF recep tor family member binds TWEAK and is implicated in angiogenesis显示文摘Wiley SR Cassiano L Lofton T 2001Immunity2001,15,5:1
5Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin 显示文摘Ishijima M Rittling SR Yamashita T 2001J Exp Med2001,193,39:1
6Hypoxia regulates vascular endothelial growth factor gene expression in endothelia cell identification of a 5′ enhancer显示文摘 Cox SR Morita T 1995Circ Res1995,77,3:1
7Long term results of a randomized prospective study of preservation of the intercostobrachial nerve 显示文摘Freeman SR Washington SJ Pritchard T 2003Eur J Surg Oncol2003,29,3:1
8Long term re- suits of arandom inzed prospective study of preservation of the in tercostobarchialnerve显示文摘Freeman SR Washington SJ Pritchard T 2003Eur J Sung Oncol2003,39,3:1
9Cloning and characterization of rat dentin matrix prmein 1 (DMPI) gem and its 5' - upstream region显示文摘Thotakura SR Karthikeyan N Smith T 2000J Bid Chem2000,275,10:1
10Immunodiagnosis of human Sparganosis mansoni by micro-chemiluminescence enzyme-linked immunosorbent assay显示文摘Nishiyama T Ide T Himes SR Jr 1994Trans R Soc Trop Med Hyg1994,88,6:1
11The effect of humic acids on the reverse osmosis treatment of hazardous landfill leachate 显示文摘Sr M Podhola M Patocka T 2012Journal of H~ardous Matm4als2012,,:1
12HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra - 1 pathway 显示文摘Ramos - Nino ME Blumen SR Sabo - Attwood T 2008Am J Respir Cell Mol Biol2008,38,2:1
13Psoriasis is common, carries a substantial burden even when not extensive, and is associated with widespread treatment dissatisfaction显示文摘Stern RS Nijsten T Feldman SR 2004Investig Dermatol Symp Proc2004,9,2:1
14Protective effect of carnosic acid,a pro-electrophilic compound,in models of oxidative stress and light-induced retinal degeneration显示文摘Rezaie T McKercher SR Kosaka K 2012Invest Ophthalmol Vis Sci2012,53,:1
15Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance显示文摘Haus JM Kashyap SR Kasumov T Zhang R Kelly KR Defronzo RA 2009Diabetes2009,58,2:1
16Dose comparisons of clopidogrel and aspirin in acute coronary Syndromes显示文摘CURRENT-OASIS T Investigators MEHTA SR BASSAND JP 2010N Engl J Med2010,363,3:1
17The prevalence of BRCA1 mutations among young women with triple negative breastcancer显示文摘Young SR Pilarski RT Donenberg T 2009BMC Cancer2009,9,4:1
18Standard-dose and50%-reduced-dose chest CT:comparing the effect on image quality显示文摘Prasad SR Wittram C Shepard JA McLoud T Rhea J 2002AJR2002,179,:1
19Separation of omphalopagus twins: unigue reconstruction using syngeneic cryopreserved tissue显示文摘Canty TG Sr Mainwaring R Vecchione T 1998J Pediatr Surg1998,33,5:1
20A controlled dose comparison of haloperidol in newly adimitted schizophrenic patients显示文摘Van Putten T Marder SR Mintz J 1994Arch Gen psychiatry1994,47,:1
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