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| 1 | Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses显示文摘His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whether the sequestration of HARS is an epiphenomenon or plays a causal role in the disease. Here, we show that HARS circulates in healthy individuals, but it is largely undetectable in the serum of anti-Jo-1-positive antisynthetase syndrome patients. In cultured primary human skeletal muscle myoblasts (HSkMC), HARS is released in increasing amounts during their differentiation into myotubes. We further show that HARS regulates immune cell engagement and inhibits CD4+ and CD8+ T-cell activation. In mouse and rodent models of acute inflammatory diseases, HARS administration downregulates immune activation. In contrast, neutralization of extracellular HARS by high-titer antibody responses during tissue injury increases susceptibility to immune attack, similar to what is seen in humans with anti-Jo-1-positive disease. Collectively, these data suggest that extracellular HARS is homeostatic in normal subjects, and its sequestration contributes to the morbidity of the anti-Jo-1-positive antisynthetase syndrome. | Ryan AAdams Cátia Fernandes-Cerqueira Antonella Notarnicola Elisabeth Mertsching Zhiwen Xu Wing-Sze Lo Kathleen Ogilvie Kyle PChiang Jeanette Ampudia Sanna Rosengren Andrea Cubitt David JKing John DMendlein Xiang-Lei Yang Leslie ANangle Ingrid ELundberg Per-Johan Jakobsson Paul Schimmel | 2021 | Cellular & Molecular Immunology2021，18，6： | 2 |
| 2 | Very low-birthweight-infants conceived by in vitro fertilization are not at higher risk for mortality and morbidity: a population-based study显示文摘 | Schimmel MS Hammerman C Lusky A | 2006 | Fertil Steril2006，85，4： | 1 |
| 3 | Characterization of pepsinogen C as a potential biomarker for gastric cancer using a histopreteomic approach 显示文摘 | Melle C Ernst G Schimmel B | 2005 | J Proteome Res2005，4，5： | 1 |
| 4 | The- transform from a wavelet point of view显示文摘 | VENTOSA S SIMON C SCHIMMEL M | 2008 | IEEE Trans- actions on Signal Processing2008，56，7： | 1 |
| 5 | The incidence of congenital heart defects in very low birth weight and extremely low birth weight infants 显示文摘 | GODFREY M SCHIMMEL M S HAMMERMAN C | 2010 | Isr Med Assoc J2010，12，1： | 1 |
| 6 | Characterization of pepsinogen C as a potential biomarker for gastric cancer using a histo-proteomic approach 显示文摘 | Melle C Ernst G Schimmel B | 2005 | J Proteome Res2005，4，5： | 1 |
| 7 | Characterization of pepsinogen C as a potential biomarker for gastric carner using a histoproteomic approach显示文摘 | Ernst G Schimmel B | 2005 | J Proteome Ras2005，4，5： | 1 |
| 8 | Characterization of pepsinogen C as a potential biomarker for gastric cancer using a histoproteomicapproach显示文摘 | Melle C Ernst G Schimmel B | 2005 | J Proteome Res2005，4，5： | 1 |
| 9 | The S-transform from a wavelet point of view显示文摘 | Ventosa S Simon C Schimmel M | 2008 | IEEE Transactions on Signal Processing2008，56，7： | 1 |
| 10 | A technical triade for proteomic identification and characterization of cancer biomarkers显示文摘 | Melle C Ernst G Schimmel B | 2004 | Cancer Res2004，64，12： | 1 |
| 11 | Characterization of pepsinogen C as a potential biomarker for gastric cancer using a histo-proteomic approach 显示文摘 | Melle C Ernst G Schimmel B | 2005 | J Proteome Res2005，4，5： | 1 |
| 12 | The incidence of congenital heart defects in very low birth weight and extremely low birth weight infants显示文摘 | Godfrey M Schimmel MS Hammerman C | | 0，，01： | 1 |
| 13 | The effects of ma- ternal age and parity on maternal and neonatal outcome 显示文摘 | Schimmel MS Bromiker R Hammerman C | 2015 | Arch Gynecol Obstet2015，291，4： | 1 |
| 14 | Petunia floral volatile benzenoid/phenylpropanoid genes are regulated in a similar manner显示文摘 | Colquhoun Thomas A Verdonk Julian C Schimmel Bernardus C J | | 0，，： | 1 |
| 15 | Hypofractionation in glioblastoma multiforme显示文摘 | Hulshof M C Schimmel E C Andries Bosch D | 2000 | Radiother Oncol2000，54，2： | 1 |
| 16 | Procalcitonin in preterm infants during the first few days of life:introducing an age related nomogram显示文摘 | Turner D Hammerman C Rudensky B Schlesinger Y Goia C Schimmel MS | | 0，，： | 1 |
| 17 | The S-transform and its inverses:side effects of discretizing and filtering显示文摘 | Simon C Ventosa S Schimmel M | 2007 | IEEE Transactions On Signal Processing2007，55，10： | 1 |
| 18 | Identification of proteins from colorectal cancer tissue by two-dimensional gel electrophoresis and SELDI mass spectrometry显示文摘 | Melle C Osterloh D Ernst G Schimmel B Bleul A von Eggeling F | 2005 | Int J Mol Med2005，16，： | 1 |
| 19 | The incidence of congenital heart defects in very low birth weight and extremely low birth weight infants 显示文摘 | GODFREY M SCHIMMEL M S HAMMERMAN C | 2010 | Isr Med Assoc J2010，12，1： | 1 |
| 20 | On the Trtransform and its diagonal dements 显示文摘 | SIMON C SCHIMMEL M DANOBEITIA J | 2008 | IEEE transactions on signal processing2008，56，11： | 1 |
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