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| 1 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 2 | Soybean trypsin inhibitors reduce absorption of exogenous and in- crease loss of endogenous protein in miniature pigs 显示文摘 | BARTH C A LUNDING B SCHMITZ M | 1993 | Nutrition1993，123，12： | 1 |
| 3 | Differential regulation of luteinizing hormone and follicle- stimulating hormone expression during ovarian development and under sexual steroid feedback in the European eel显示文摘 | Schmitz M Aroua S Vidal B | 2005 | Neuroendocrinology2005，81，2： | 1 |
| 4 | CikA, a bacteriophytochrome that re- sets the cyanobacterial circadian clock 显示文摘 | Schmitz O Katayama M Williams S B Kondo T Golden S S | 2000 | Sci- ence2000，289，： | 1 |
| 5 | Generation of s urvivin-specific CD8 ^+ T effector cells by dendritic cells pulsed with protein or selected peptides 显示文摘 | SCHMITZ M DIESTELKOETFER P WEIGLE B | 2000 | Cancer Res2000，60，17： | 1 |
| 6 | Expression pattern, genomic cloning and RFLP analyses of the swine PIT-1 gene 显示文摘 | Yu T P Schmitz C B Rothschild M F | 1994 | Animal Genetics1994，25，： | 1 |
| 7 | Depression in Epilepsy :Mechanisms and Therapeutic Approaches显示文摘 | Schmitz B Mula M | 2009 | Ther Adv Neurol Disord2009，2，5： | 1 |
| 8 | Screening of environmental DNA libraries for the presence of genes conferring lipolytic activity on Escherichia coli显示文摘 | Henne A Schmitz R A B(o)meke M | 2000 | Appl Environ Microbiol2000，66，7： | 1 |
| 9 | The structure of adenovirus type 12 DNA integration sites in the hamster cell genome显示文摘 | Knoblauch M Schroer J Schmitz B | 1996 | J Virol1996，70，6： | 1 |
| 10 | Expression pattern,genomic cloning and RFLP analyses of the swine POU1F1 gene显示文摘 | Yu T P Schmitz C B Rothschild M F | | 0，，： | 1 |
| 11 | Networks,clusters and innova-tion in tourism: A UK experience显示文摘 | Novelli M Schmitz B Spence T | 2006 | Tourism Management2006，27，6： | 1 |
| 12 | Control of plant growth by nitrogen and phosphorus in mesotrophic fens显示文摘 | VERHOEVEN J T A SCHMITZ M B | | 0，，02： | 1 |
| 13 | Resuscitation from cardiac arrest in cats: influence of epinephrine dosage on brain recovery 显示文摘 | Schmitz B Fischer M Bockhorst K | 1995 | Resuscitation1995，，30： | 1 |
| 14 | Aggressive conven- tional chemotherapy compared with high-dose chemother- apy with autologous haemopoietic stem-cell transplanta- tion for relapsed chemosensitive Hodgkints disease:a ran- domised trial显示文摘 | Schmitz N Pfistner B Sextro M | 2002 | Lancet2002，359，9323： | 1 |
| 15 | A simplified method of preparing phosphoric acid for stable isotope analysis of carbonates 显示文摘 | Burman J Gustafsson O Segl M Schmitz B | 2005 | Rapid Communications in Mass Spectrometry2005，19，21： | 1 |
| 16 | Familial form of hirschsprung disease:nucleotide sequence studies reveal point mutations in the RET proto-oncogene in two of six families but not in other candidate genes显示文摘 | Munnes M Fanaei S Schmitz B | 2000 | Am J Med Genet2000，94，： | 1 |
| 17 | A 5'-CG-3'-rich region in the promoter of the transcriptionally frequently silenced RET protooncogene lacks methylated cytidine residues显示文摘 | Munnes M Patrone G Schmitz B | 1998 | Oncogene1998，17，20： | 1 |
| 18 | A genome-wide survey of RAS transformation targets显示文摘 | Zuber J Tchernitsa O I Hinzmann B Schmitz A C Grips M Hellriegel M | 2000 | Nat Genet2000，24，： | 1 |
| 19 | Networks, clusters and innovation in tourism: AUK experience显示文摘 | Novelli M Schmitz B Spencer T | 2006 | Tourism Management2006，27，6： | 1 |
| 20 | Soybean trypsin inhibitors reduce absorption of exogenous and increase loss of endogenous protein in iniature pigs显示文摘 | Barth C A Lurnling B Schmitz M | 1993 | Nutrition1993，，123： | 1 |
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