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| 1 | Improved guided bone regeneration by combined application of unmodified, fresh autologous adipose derived regenerative cells and plasma rich in growth factors:A first-in-human case report and literature review显示文摘BACKGROUND Novel strategies are needed for improving guided bone regeneration(GBR) in oral surgery prior to implant placement, particularly in maxillary sinus augmentation(GBR-MSA) and in lateral alveolar ridge augmentation(LRA). This study tested the hypothesis that the combination of freshly isolated, unmodified autologous adipose-derived regenerative cells(UA-ADRCs), fraction 2 of plasma rich in growth factors(PRGF-2) and an osteoinductive scaffold(OIS)(UAADRC/PRGF-2/OIS) is superior to the combination of PRGF-2 and the same OIS alone(PRGF-2/OIS) in GBR-MSA/LRA.CASE SUMMARY A 79-year-old patient was treated with a bilateral external sinus lift procedure as well as a bilateral lateral alveolar ridge augmentation. GBR-MSA/LRA was performed with UA-ADRC/PRGF-2/OIS on the right side, and with PRGF-2/OIS on the left side. Biopsies were collected at 6 wk and 34 wk after GBRMSA/LRA. At the latter time point implants were placed. Radiographs(32 mo follow-up time) demonstrated excellent bone healing. No radiological or histological signs of inflammation were observed. Detailed histologic,histomorphometric, and immunohistochemical analysis of the biopsies evidenced that UA-ADRC/PRGF-2/OIS resulted in better and faster bone regeneration than PRGF-2/OIS.CONCLUSION GBR-MSA with UA-ADRCs, PRGF-2, and an OIS shows effectiveness without adverse effects. | ?nder Solakoglu Werner G?tz Maren C Kiessling Christopher Alt Christoph Schmitz Eckhard U Alt | 2019 | World Journal of Stem Cells2019，11，2： | 3 |
| 2 | Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges显示文摘 | Christians U Schmitz V Schoning W | 2008 | Ther Drug Monit2008，30，2： | 1 |
| 3 | Assimilation and metabolism of formaldehyde by leaves appear unlikely to be of value for indoor air purification显示文摘 | SCHMITZ H HILGERS U WEIDNER M | 2000 | New Phytologist2000，147，2： | 1 |
| 4 | Long-term graft acceptance after rat liver allograft transplantation induced by application of CTLA4-Ig anddonor specific spleen cell administration 显示文摘 | Neumann UP Fischer U Schmitz V | 2002 | Transplant Proc2002，34，5： | 1 |
| 5 | Assimilation and metabolism of formaldehyde by leaves appear unlikely to be of value for indoor air purification 显示文摘 | Schmitz H Hilgers U Weidner M | 2000 | New Phytologist2000，147，2： | 1 |
| 6 | Brace effect in scoliosis in the sagittal plane - an MRI study显示文摘 | Schmitz A Kandyba J Jaeger U | 2002 | Z Orthop Ihre Grenzgeb2002，140，3： | 1 |
| 7 | Massive pulmonary embolism: pereutaneous emergency treatment by pigtail rotation catheter显示文摘 | SCHMITZ - RODE T JANSSENS U DUDA SH | 2000 | J Am Coll Cardiol2000，36，2： | 1 |
| 8 | Activity of cAMP-dependent protein kinase and Ca^2+/calmodulin-dependent protein kinase in failing and nonfaiing human hearts 显示文摘 | Kirchhefer U Schmitz W Scholz H | 1999 | Cardiovasc Res1999，42，： | 1 |
| 9 | Biodiversity in Berlin and its potential for nature conservation 显示文摘 | Zerbe S Maurer U Schmitz S | 2003 | Landscape and Urban Planning2003，62，3： | 1 |
| 10 | Bile duct injury and use of cholangiography during laparoscopic cholecystec-tomy显示文摘 | GIGER U OUAISSI M SCHMITZ SF | 2011 | BrJ Surg2011，98，3： | 1 |
| 11 | Comparison of intravenous immunoglobulinpreparations on microglial function in vitro :more potent immunomodulatory capacity of an IgM/IgA-enriched preparation显示文摘 | Nguyen D Schmitz U | 2002 | Clin Neuropharmacol2002，25，5： | 1 |
| 12 | Features of probable multiple system atrophy patients identified among 4770 patients with parkinsonism enrolled in the multicentre registry of the German Competence Network on Parkinson's disease显示文摘 | Wüllner U Schmitz Hübsch T Abele M | 2007 | J Neural Transm2007，114，9： | 1 |
| 13 | Surgical manipulation,but not moderate exercise,is associated with increased cytokine mRNA expression in the rat sole us muscle显示文摘 | Schmitz Thurod H-M Wislff U Lund PK | 2002 | Acta Physiol Scand2002，175，9： | 1 |
| 14 | Biodiversity in Berlin and its potential for nature conservation显示文摘 | Zerbe S Maurer U Schmitz S | 2003 | Landscape Urban Plan2003，62，： | 1 |
| 15 | Assimilation and metabolism of formaldehyde by leaves appear unlikely to be of value for indoor air purification显示文摘 | Schmitz H Hilgers U Weidner M | 2000 | New Phytologist2000，147，： | 1 |
| 16 | Advanced speckle tracking echocardio-graphy allowing a three-myocardial layer-specific analysis of deformation parameters显示文摘 | Adamu U Schmitz F Becker M | 2009 | Euro J Echocardio2009，10，2： | 1 |
| 17 | Induction of longterm graft acceptance by a combiunation treatmengt of donor splenocytes and CTLA4 lg in a high responder rat liver transplantation model显示文摘 | Schmitz V Neuman U P Fischer U | 2005 | Transpl Int2005，18，10： | 1 |
| 18 | Biodiversity in Berlin and its potential for nature conservation 显示文摘 | ZERBE S MAURER U SCHMITZ S | 2003 | Landscape and Urban Planning2003，62，3： | 1 |
| 19 | SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130显示文摘 | Lehmann U Schmitz J Weissenbach M | 2003 | J Biol Chem2003，278，1： | 1 |
| 20 | RIBEYE, a component of synaptic ribbon: a protein's journey through evolution provides insight into synaptic ribbon function显示文摘 | Schmitz F Konigstorfer A S u dhof TC | 2000 | Neuron2000，28，： | 1 |
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