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| 1 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 2 | Identification of an invasion-inducing gene,Tiam-1,that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins显示文摘 | Habets GG Scholtes EH Zuydgeest D | 1994 | Cell1994，77，4： | 1 |
| 3 | Usefulness of hypertrig lyceridemic waist phenotype in type 2 diabetes mellitus to predict the presence of coronary artery disease as assessed by computed tomographic coronary angiography显示文摘 | de-Graaf F R Schuijf J D Scholte A J | 2010 | Am J Cardiol2010，106，12： | 1 |
| 4 | Effect of multilev- el Botulinum toxin A and comprehensive rehabilitation on gait in cerebral palsy 显示文摘 | Scholtes VA Dallmeijer AJ Knol DL | 2007 | Pediatr Neurol2007，36，： | 1 |
| 5 | Indentification of an invasion-inducing gene,Tiaml,that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins显示文摘 | Habets GG Scholtes EH Zuydgeest D | 1994 | Cell1994，77，： | 1 |
| 6 | Differences between patients with a preserved and a depressed left ventricular function: a report from the Euro Heart Failure Survey 显示文摘 | Lenzen MJ Scholte op Reimer WJ Boersma E | 2004 | Eur Heart J2004，25，14： | 1 |
| 7 | Cognitive deterioration and electrical status epilepticus during slow sleep 显示文摘 | Scholtes FB Hendrika MP Renier WO | 2005 | Epilepsy Behav2005，6，2： | 1 |
| 8 | The influence of process parameters and starting composition on the carbothermal production of sialon显示文摘 | KOKMEIJER E SCHOLTE C BLOMER F | 1990 | J Mater Sci1990，25，： | 1 |
| 9 | A survey on automateddynamic malware-analysis techniques and tools显示文摘 | EGELE M SCHOLTE T KIRDA E | 2012 | ACM CompU-ting Surveys2012，44，2： | 1 |
| 10 | Secretion of hepatitis C virus envelope glycoproteins depends on assembly of apolipoprotein B positive lipoproteins显示文摘 | Icard V Diaz O Scholtes C | 2009 | PLoS One2009，4，： | 1 |
| 11 | Repetitive transcranial magnetic stimulation improves open field locomotor recovery after low but not high thoracic spinal cord compression-injury in adult rats 显示文摘 | Poirrier AL Nyssen Y Scholtes F | 2004 | J NeurosciRes2004，75，2： | 1 |
| 12 | Mathematical programs with complementarity constraints:stationarity,optimality and sensitivity显示文摘 | Scheel H Scholtes S | 2000 | Mathematics of Operations Research2000，25，： | 1 |
| 13 | Relation between growth conditions and dormancy of seed potatoes. 2. Effects of temperature显示文摘 | M. K. Ittersum K. Scholte | 1992 | Potato Research1992，，： | 1 |
| 14 | Changes in multidirectional LV strain in asymptomatic patients with type 2 diabetes mellitus: a 2-year follow-up study 显示文摘 | Roos C J Scholte A J Kharagjitsingh AV | 2014 | Eur Heart J Cardiovasc Imaging2014，15，1： | 1 |
| 15 | Prevalence and predictors of an abnormal stress myocardial perfusion study in asymptomatic patients with type 2 diabetes mellitus显示文摘 | Scholte AJ Schuijf JD Kharagjitsingh AV | 2009 | Eur J Nucl Med Mol Imaging2009，36，： | 1 |
| 16 | Fatigue and residual stress relaxation of deep rolled differently aged aluminium alloy AA6110显示文摘 | JUIJERM P ALTENBERGER I SCHOLTES B | 2006 | Materials Science and Engineering:A2006，426，12： | 1 |
| 17 | Mental health symptoms following war and repression in eastern Afghanistan显示文摘 | Scholte WF Olff M Ventevogel P etal | 2004 | JAMA2004，292，5： | 1 |
| 18 | New-onset atrial fibrilla- tion is an independent predictor of in-hospital mortality in hospitalized heart failure patients: results of the EureHeart Failure Survey 显示文摘 | Rivero-Ayerza M Scholte Op Reimer W Lenzen M | 2008 | Eur Heart J2008，29，13： | 1 |
| 19 | An ento- mopathogenic fungus for control of adult African ma- laria mosquitoes显示文摘 | Scholte E J Ng' habi K Kihouda J | 2005 | Science2005，308，： | 1 |
| 20 | Direct Spray Coating of Photoresist for MEMS Applications显示文摘 | Pham N P Scholtes T Klerk R | 2001 | SPIE2001，4557，： | 1 |
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