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| 1 | Pain and chronic pancreatitis: A complex interplay of multiple mechanisms显示文摘Despite multiple theories on the pathogenesis of pain in chronic pancreatitis,no uniform and consistently successful treatment strategy exists and abdominal pain still remains the dominating symptom for most patients and a major challenge for clinicians.Traditional theories focussed on a mechanical cause of pain related to anatomical changes and evidence of increased ductal and interstitial pressures.These observations form the basis for surgical and endoscopic drainage procedures,but the outcome is variable and often unsatisfactory.This underscores the fact that other factors must contribute to pathogenesis of pain,and has shifted the focus towards a more complex neurobiological understanding of pain generation.Amongst other explanations for pain,experimental and human studies have provided evidence that pain perception at the peripheral level and central pain processing of the nociceptive information is altered in patients with chronic pancreatitis,and resembles that seen in neuropathic and chronic pain disorders.However,pain due to e.g.,complications to the disease and adverse effects to treatment must not be overlooked as an additional source of pain.This review outlines the current theories on pain generation in chronic pancreatitis which is crucial in order to understand the complexity and limitations of current therapeutic approaches.Furthermore,it may also serve as an inspiration for further research and development of methods that can evaluate the relative contribution and interplay of different pain mechanisms in the individual patients,before they are subjected to more or less empirical treatment. | Jakob Lykke Poulsen Sφren Schou Olesen Lasse Paludan Malver Jens Brφndum Frφkjr Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 5 |
| 2 | Nutrition in chronic pancreatitis显示文摘The pancreas is a major player in nutrient digestion.In chronic pancreatitis both exocrine and endocrine insufficiency may develop leading to malnutrition over time.Maldigestion is often a late complication of chronic pancreatic and depends on the severity of the underlying disease.The severity of malnutrition is correlated with two major factors:(1)malabsorption and depletion of nutrients(e.g.,alcoholism and pain)causes impaired nutritional status;and(2)increased metabolic activity due to the severity of the disease.Nutritional deficiencies negatively affect outcome if they are not treated.Nutritional assessment and the clinical severity of the disease are important for planning any nutritional intervention.Good nutritional practice includes screening to identify patients at risk,followed by a thoroughly nutritional assessment and nutrition plan for risk patients.Treatment should be multidisciplinary and the mainstay of treatment is abstinence from alcohol,pain treatment,dietary modifications and pancreatic enzyme supplementation.To achieve energy-end protein requirements,oral supplementation might be beneficial.Enteral nutrition may be used when patients do not have sufficient calorie intake as in pylero-duodenalstenosis,inflammation or prior to surgery and can be necessary if weight loss continues.Parenteral nutrition is very seldom used in patients with chronic pancreatitis and should only be used in case of GI-tract obstruction or as a supplement to enteral nutrition. | Henrik Hφjgaard Rasmussen φivind Irtun Sφren Schou Olesen Asbjφrn Mohr Drewes Mette Holst | 2013 | World Journal of Gastroenterology2013，19，42： | 4 |
| 3 | CFAR edge detector for polarimetric SAR images 显示文摘 | Schou J Skriver H Nielson A A | 2003 | IEEE Transactions on Geoscience and Remote Sensing2003，41，1： | 1 |
| 4 | Growth and Non-renewable Re- sources: the Different Roles of Capital and Re- source Taxes显示文摘 | Groth Schou | 2007 | Journal of Environmental Eco- nomics and Management2007，，53： | 1 |
| 5 | Effects of reflectors, black boards, or shades applied at different stages of plant development on yield of soybeans显示文摘 | Schou J B Jeffers D L Streeter J G | 1978 | Crop Science1978，18，： | 1 |
| 6 | Maxillary sinus floor augmentation with Bio-Oss or Bio-Oss mixed with autogenous bone as graft:a systematic review显示文摘 | Jensen T Schou S Stavropoulos A | 2012 | Clin Oral Implants Res2012，23，3： | 1 |
| 7 | Combined eco-logical and economic modelling in agricultural land usescenarios 显示文摘 | Milnier B Birr Pedersen K Schou J S | 2004 | Ecological Modelling2004，174，1： | 1 |
| 8 | Democracy in Education显示文摘 | Schou Lotte Rahbek | 2001 | Studies in Philosophy and Education2001，20，4： | 1 |
| 9 | Synthesis and pharmacological evaluatin of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethyl-Sulfonyl penyl) acylamide derivatives as potential activators of ATP sensitive potassium channels显示文摘 | SCHOU S C HANSEN H C TAGMOSE T M | 2005 | Bioorg Med Chem2005，13，： | 1 |
| 10 | Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight显示文摘 | Schou JH Pilgaard K Vilsboll T | 2005 | J Clin Endocrinol Metab2005，90，8： | 1 |
| 11 | Prediction of outcome by highly sensitive troponin T in outpatients with chronic systolic left ventricular heart failure显示文摘 | Egstrup M Schou M Tuxen CD | 2012 | Am J Cardiol2012，110，4： | 1 |
| 12 | Unexplained week-to-week variation in BNP and NT-proBNP is low in chronic heart failure patients during steady state显示文摘 | Schou M Gustafsson F Nielsen PH | 2007 | Eur J Heart Fail2007，9，： | 1 |
| 13 | The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropie action of ineretin hormones, reduced 24 h profiles of plasma insulin and glueagon,and increased hepatic glucose production in young healthy men 显示文摘 | Pilgaard K Jensen CB Schou JH et at | 2009 | Diabetologia2009，52，7： | 1 |
| 14 | Kidneys extract BNP and NT-proBNP in healthy young men显示文摘 | Schou M Dalsgaard MK Clemmesen O | 2005 | J AN Physiol2005，99，5： | 1 |
| 15 | When Environmental Policy is Superfluous:Growth and Polluting Resources显示文摘 | SCHOU P | 2002 | Scandinavian Journal of Economics2002，104，： | 1 |
| 16 | A temporal same- object advantage in the tunnel effect: Facilitated change detection for persisting objects 显示文摘 | Flombaum J I SchoU B J | 2006 | Journal of Experimental Psychology: Human Perception & Performance2006，32，4： | 1 |
| 17 | Immigration, integration and fiscal sustainability 显示文摘 | Poul Schou J Popul Econ | 2006 | Journal of Population Economics2006，，： | 1 |
| 18 | Unexplained week-to-week variation in BNP and NT-pro BNP is low in chronic heart failure patients during steady state显示文摘 | Schou M Gu stafsson F Nielsen PH | 2007 | Eur J Heart Fail2007，9，1： | 1 |
| 19 | Prognostic usefulness of anemia and N-terminal pro-brain natriuretic peptide in outpatients with systolic heart failure显示文摘 | Schou M Gustafsson F Kistorp CN | 2007 | Am J Cardio2007，100，10： | 1 |
| 20 | Boric acid single dose pharmacokineties after intravenous administration to man显示文摘 | Jansen J A Andersen J Schou J S | 1984 | Arch Toxicol1984，55，1： | 1 |
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