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| 1 | 星形胶质细胞通过分泌IL-23促进黑色素瘤脑转移显示文摘黑色素瘤是最主要皮肤致死性恶性肿瘤,黑色素瘤患者死亡的主要原因是远处转移,常为脑转移。微环境在肿瘤的发生和转移中起着关键的作用,为了治疗或预防转移,必须阐明播散的肿瘤细胞与转移性器官微环境之间的相互作用。然而,大脑间质细胞在促进转移性生长中的作用却知之甚少。星形胶质细胞的主要功能是大脑损伤后修复和形成胶质瘢痕,部分因为通过介导神经炎症,但是星形胶质细胞在黑色素瘤脑转移中的作用却不清楚。 | Klein A Schwartz H Sagi-Assif O 陈达阳 王行富 | 2015 | 临床与实验病理学杂志2015，31，11： | 4 |
| 2 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 3 | 囊泡型H^+-ATPase B1亚基的突变对大鼠内髓集合管细胞H^+-ATPase结构和泵氢功能的影响显示文摘目的研究致遗传性远端肾小管酸中毒(dRTA)的囊泡型H^+-ATPaseB1亚基(ATP6V181)的点突变对大鼠内髓集合管(IMCD)细胞H^+-ATPase结构和泵氢功能的影响。方法模拟致人类遗传性dRTA的B1亚基点突变构建野生型(WT)和7种突变型(M)质粒,转染大鼠IMCD细胞并筛选稳定表达绿色荧光蛋白(CFP)-B1 M和GFP—B1 WT的IMCD细胞系。应用免疫荧光、免疫蛋白印迹法、ATP。NADH耦合实验和快速酸负荷后不依赖钠的细胞内pH的变化,来观察GFP—B1 M和GFP—B1 WT在细胞内的分布,及其与H^+-ATPase其他(E、H和c)亚基结合能力对ATP酶活性和H^+-ATPase泵氢功能的影响。结果GFP.B1wT在转染细胞中呈囊泡样分布,与H^+-ATPase的分布一致;而GFP—B1 M则为弥散分布。免疫沉淀结果显示只有GFP—B1 WT融合蛋白能和其他的H^+-ATPase亚基(E、H和c)结合形成复合物,而GFP-B1 M融合蛋白无此作用。ATP酶活性只有在GFP—B1 WT转染细胞株的免疫沉淀产物中存在,在GFP—B1 M转染细胞株的免疫沉淀产物中不存在。在GFP—B1 M转染的IMCD细胞快速酸负荷后H^+-ATPase介导的钠不依赖pHi的恢复受到显著抑制[pHi的恢复率(pHU/min)在L81P、R124W、M174R、P275R、G316E、P346R、G364S GFP—B1M转染的IMCD细胞分别为0.007±0.002、0.004±0.002、0.002±0.002、0.003±0.002、0.006±0.004、0.009±O.004、0.015±0.006,P〈0.05,n=51。而GFP—B1 WT转染的IMCD细胞pHi的恢复率与未转染IMCD细胞相似[(0.040±0.006)pH U/min],且能被1μmol/L巴弗洛霉素(H^+-ATPase特异性抑制剂)所抑制。结论遗传性dRTA囊泡型H^+-ATPaseB1亚基点突变影响GFP—B1融合蛋白与其他亚基正常结合组装形成完整的H^+-ATPase,并抑制H^+-ATPase的泌酸功能。 | 杨琼琼 毛海萍 李广木 John H Schwartz 余学清 | 2009 | 中华肾脏病杂志2009，25，1： | 3 |
| 4 | Volumetric Analysis Predicts Hepatic Dysfunction in Patients Undergoing Major Liver Resection显示文摘 | Margo Shoup Mithat Gonen Michael D’Angelica William R Jarnagin Ronald P DeMatteo Lawrence H Schwartz Scott Tuorto Leslie H Blumgart Yuman Fong | 2003 | Journal of Gastrointestinal Surgery2003，，3： | 2 |
| 5 | Correlation of expression of BP1,a homeobox gene,with estrogen receptor status in breast cancer 显示文摘 | Fu SW Schwartz A Stevenson H | 2003 | Breast Cancer Res2003，5，4： | 1 |
| 6 | Isolation and characterization of neural progenitor cells from post-mortem human cortex显示文摘 | SCHWARTZ P H BRYANT P J FUJA T J | 2003 | J Neurosci Res2003，74，6： | 1 |
| 7 | Cadherin-catenin complex:protein interactions and their implications for cadherin function显示文摘 | Aberle H Schwartz H Kemler R | 1996 | J Cell Biochem1996，61，4： | 1 |
| 8 | Contribution of technical materials to the mobile fraction of metals in urban soils in Marrakech (Morocco) 显示文摘 | Khalil H E Schwartz C Elhamiani O | 2008 | Journal of Soils and Sediments2008，8，1： | 1 |
| 9 | Temporal evolution of the human coronary collateral circulation after myocardial infarction 显示文摘 | Schwartz H Leiboff RH Brcn GB | 1984 | J Amer Coil Cardio1984，4，6： | 1 |
| 10 | Forced Response of a Cantilever Beam with a Dry Friction Damper Attached PartI: Theory 显示文摘 | Dowel E H Schwartz H B | 1983 | Journal of Sound and Vibration1983，91，2： | 1 |
| 11 | Taxotere-induced inhibition of human endothelial cell migration is a result of heat shock protein 90 degradation 显示文摘 | Murtagh J Lu H Schwartz E L | 2006 | Cancer Res2006，66，16： | 1 |
| 12 | Ruboxistaurin mesilate hydrate for diabetic retinopathy 显示文摘 | Schwartz S G Flynn H W Aiello L P | 2009 | Drugs Today2009，45，4： | 1 |
| 13 | MR imaging of the breast with rotating delivery of excition off resonance clinical experience with pathologic correlation显示文摘 | Morris E A Schwartz L H Dershaw D D | 1993 | Radiology1993，187，2： | 1 |
| 14 | Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome:A worldwide report显示文摘 | SCHWARTZ P J LOCATI E H MOSS A J | 1991 | Circulation1991，84，2： | 1 |
| 15 | Preparation and comparison of supported gold nanocatalysts on anatase, brookite, rutile, and P25 polymorphs of TiO2 for catalytic oxidation of CO 显示文摘 | Yan Wenfu Chen Bei Mahurin S M Schwartz V Mullins D R Lupini R Andrew Pennycook S J Dai Sheng Overbury S H | 2005 | Journal of Physical Chemistry B2005，109，10： | 1 |
| 16 | Alternate estrogen re- ceptors promote invasion of inflammatory breast cancer cells via non- genomic signaling显示文摘 | Ohshiro K Schwartz A M Levine P H | 2012 | PLoS One2012，7，30： | 1 |
| 17 | Culturing of calcium stable adult cardiac myocytes显示文摘 | PIPER H M PROBST I SCHWARTZ P | 1982 | J Mol Cell Cardiol1982，14，： | 1 |
| 18 | Improvement in glycemic excursions with a transcutaneous,real-time continuous glucose sensor A randomized controlled trial显示文摘 | Garg S Zisser H Schwartz S | 2006 | Diabetes care2006，29，1： | 1 |
| 19 | Universals in the Content and Structure of Values :Theoretical Advances and Empirical Tests in 20 Countries 显示文摘 | Schwartz S H | 1992 | Advances in Experimental Social Psychology1992，25，1： | 1 |
| 20 | Seven-day therapy for helicobacter pylori in the United States显示文摘 | Vaki N Lanza F Schwartz H | 2004 | Aliment Pharmacol Ther2004，20，： | 1 |
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