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| 1 | Oral eplerenone for the management of chronic central serous chorioretinopathy显示文摘AIM: To examine eplerenone(Inspra, Pfizer), a mineralocorticoid receptor antagonist, as a treatment option for chronic central serous chorioretinopathy(CSCR).METHODS: A retrospective consecutive case series was conducted for patients receiving oral eplerenone for chronic CSCR. At baseline and each follow-up visit,spectral domain optical coherence tomography(SD-OCT)imaging was performed, including manual measurements of the height and diameter size of subretinal fluid. The primary outcome measure was the reduction in subretinal fluid following initiation of therapy.RESULTS: A total of 17 eyes of 13 patients treated with25 and 50 mg of oral eplerenone per day were identified.Subretinal fluid(SRF) decreased over time following eplerenone therapy(P = 0.007 and P =0.002, diameter and height respectively). Maximum SRF height decreased from a mean of 131.5 μm at baseline to 15.3 μm at day181+. SRF diameter decreased from an average of 2174.4μm at baseline to 46.9 μm at day 181 +. Log MAR visual acuity improved from 0.42(Snellen equivalent: 20/53) at baseline to 0.29(Snellen equivalent: 20/39) at day 181 +(P = 0.024). Central subfield thickness(CST) decreased from 339.5 μm at baseline to 270.3 μm at day 181+(P = 0.029).CONCLUSION: Eplerenone therapy resulted in significant anatomic and visual improvements in eyes with chronic CSCR. | Rishi P Singh Jonathan E Sears Rumneek Bedi Andrew P Schachat Justis P Ehlers Peter K Kaiser | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 6 |
| 2 | Myoxardial ischemia in untreat- ed hypertensive patients : effect of a single small oral dose of a beta- adremergic blocking agent 显示文摘 | Stone JG Foix P Sear JW | 1988 | Anethesioligy1988，68，4： | 1 |
| 3 | PPARgammaactivation in adipocytes is suficient for systemic insu lin sensitization显示文摘 | SUGII S OLSON P SEARS D D | 2009 | Proc Nat! Acad Sci U S A2009，106，22： | 1 |
| 4 | Genetic gain in yield at- tributes of winter wheat in the great plains 显示文摘 | Donmez E Sears R G Shroyer J P | 2001 | Crop Sci2001，，41： | 1 |
| 5 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 6 | Experiment and theory for heterogeneous nucleation of protein crystals in a porous medium显示文摘 | Chayen N E Saridakis E Sear R P | 2006 | Proc Natl Acad Sci USA2006，103，3： | 1 |
| 7 | A weak calcium binding site in subtilisin BPN has a dramatic effect on protein stability 显示文摘 | R D Kidd H P Yennawar P Sears CH Wong G K Farber | 1996 | Am Chem Soc1996，118，： | 1 |
| 8 | Gasification of brown coal and char with carbon dioxide in the presence of finely dispersed iron catalysts显示文摘 | Asami K Sears P Furimsky E | 1996 | Fuel Processing Technology1996，47，2： | 1 |
| 9 | Enhancement of Finserprints in Blood Part 3 :Reactive Tech- niques, Acid Yellow and Process Sequences, Journal of Foren- sic Identification显示文摘 | Vaughn G Sears Butcher Colin P G Fitzgerald Lesley A | 2005 | 55(6):7412005，55，6： | 1 |
| 10 | Exacerbations of asthma without sputum eosinophilia显示文摘 | Turner MOP Hussack P Sears MR | 1995 | Thorax1995，50，10： | 1 |
| 11 | Treatment of malignant fibrous histiocytoma of the heart显示文摘 | Sears Rogan P Bitterman P | 1992 | Cancer1992，69，4： | 1 |
| 12 | Volatility, price resolution, and the effectiveness of price limits 显示文摘 | Ma C K Rao R P Sears R S | 1989 | Journal of Financial Services Research1989，，3： | 1 |
| 13 | Experiment and Theory for Heterogeneous Nucleation of Protein Crystals in a PorousMedium显示文摘 | Chayen N E Saridakis E Sear R P | 2006 | Proc Natl Acad Sci USA2006，103，3： | 1 |
| 14 | Themurine homolog of the interleukin-8 receptor cxcr-2 is essential for the occurrence of neutrophilic inflammation in air pouchmodel of acute urate crys-tal-induced gouty synovitis显示文摘 | Terkeltaub R Baird S Sears P | 1998 | Arthritis Rheum1998，41，5： | 1 |
| 15 | A weak calcium binding site in subtilisin BPN-has a dramatic effect on protein stability显示文摘 | R D Kidd H P Yennawar P Sears C H Wong G K Farber | 1996 | Am Chem Soc1996，118，： | 1 |
| 16 | Sleep problems in children with autism显示文摘 | Gail-Williams P Sears L L Allard A | 2004 | J Sleep Res2004，13，3： | 1 |
| 17 | Cortically evoked depolarization of primary afferent fibers in the spinal cord 显示文摘 | Eccles JC Sears TA | 1964 | J Neurophysiol1964，27，： | 1 |
| 18 | Hypertension, hypertensive heart disease and perioperative cardiac risk 显示文摘 | Howell S Sear JW Foex P | 2004 | BJA2004，92，4： | 1 |
| 19 | Peri-operative beta-blockade: a useful treatment that should be greeted with cautious enthusiasm显示文摘 | Howell SJ Sear JW Foex P | 2001 | Br J Anaesth2001，86，2： | 1 |
| 20 | The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis 显示文摘 | Terkeltaub R Baird S Sears P | 1998 | Arthritis Rheum1998，41，5： | 1 |
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