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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Incidence and predictors of glaucoma following surgery for congenital cataract in the first year of life in V ictoria, A ustralia显示文摘 | Jonathan B Ruddle Sandra E Staffieri Jonathan G Crowston Justin C Sherwin David A Mackey | 2013 | Clin Experiment Ophthalmol2013，，7： | 1 |
| 3 | The use of GIS to develop a probability-based trunk mains burst risk model 显示文摘 | Cooper N R Blakey G Sherwin C | 2000 | Urban Water2000，2，2： | 1 |
| 4 | Traditional and novel reservoir management techniques to enhance water quality for subsequent potable water treatment显示文摘 | Bayley R Ta C T Sherwin C J | 2001 | Particle Removal from Reservoirs and Other Surface Waters2001，1，1： | 1 |
| 5 | Effects of environmental enrichment,fluorescent and intermittent lighting on injurious pecking amongst male turkey poults 显示文摘 | Sherwin C M Lewis P D Perry G C | 1999 | British Poultry Science1999，40，： | 1 |
| 6 | Domestic turkeys are not averse to compact fluorescent lighting 显示文摘 | Sherwin C M | 1999 | Applied Animal Behaviour Science1999，64，： | 1 |
| 7 | Cave air and hydrological controls on priorcalcite precipitation and stalagmite growth rates : Implications forpalaeoclimate reconstructions using speleothems显示文摘 | Sherwin C M Baldini JUL | 2011 | Geochimica etCosmochimicaActa2011，75，14： | 1 |
| 8 | Contortostatin, a dimeric disintegrin from Agkistrodon contortrlx, inhibits breast cancer progression 显示文摘 | Zhou Q Sherwin R P Parrish C | 2000 | Breast Cancer Res Treat2000，61，： | 1 |
| 9 | Regulation of S-Adenosylmethionine levels in Saccharomyces cerevisiae显示文摘 | SHERWIN Y C DEAN R A | 2003 | J Biol Chem2003，278，43： | 1 |
| 10 | Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo显示文摘 | SANJA R SHERWIN Y C FATMA K | 2002 | J Biol Chem2002，277，6： | 1 |
| 11 | Studies on the motivation for burrowing by laboratory mice显示文摘 | Sherwin C M Haug E Terkelsen N | | 0，，3： | 1 |
| 12 | Comparison of the behaviour of broiler chickens in indoor and free-range environments显示文摘 | Weeks C Nicol C Sherwin C | 1994 | Animal Welfare1994，3，3： | 1 |
| 13 | Design and sustainabi]ity: a discussion paper based on personal experience and observations 显示文摘 | Sherwin C | 2004 | The Journal of Sustainable Product Design2004，，4： | 1 |
| 14 | Impaired insulin action in puberty 显示文摘 | AMIEL S A SHERWIN R S SIMONSON D C | 1986 | N Engl J Med1986，315，4： | 1 |
| 15 | Modelling the Long Term Water Yield Impact of Wildfire and Other Forest Disturbance in Eucalypt Forests显示文摘 | Lane P N J Feikema P M Sherwin C B | 2010 | Environmental Modelling Software2010，25，： | 1 |
| 16 | Identification of genes regulated by leukemia inhibitoty factor in the mouse uterus at the time of implantation显示文摘 | Sherwin J R Freeman T C Stephens R J | 2004 | Mol Endocrinol2004，18，9： | 1 |
| 17 | Xylem hydrau- lic characteristics of subtropical trees from contrasting habi- tats grown under identical environmental conditions显示文摘 | Willigen C V Sherwin H W Pammenter N W | 2000 | New Physiologist2000，145，1： | 1 |
| 18 | Some early developments in synthetic aperture radar system显示文摘 | Sherwin C W Ruina J P Raweliffe R D | 1962 | IRE trans on MIL1962，6，2： | 1 |
| 19 | Some early developments in synthetic aperture radar systems显示文摘 | Sherwin C W Ruina J P Rawcliffe R D | 1962 | IRE Transactions on Military Electronics1962，6，2： | 1 |
| 20 | Identification of genes regulated by leukemia-inhibitory factor in the mouse uterus at the time of implantation显示文摘 | Sherwin JRA Freeman T C Step hens R J | 2004 | Mol Endocrinol2004，18，9： | 1 |
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