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| 1 | WRN解旋酶是治疗微卫星不稳定型癌症的新靶点显示文摘由基因突变或启动子超甲基化引发的DNA错配修复(MMR)缺陷会造成核苷酸重复区(微卫星)序列超突变,即微卫星不稳定性(MSI).MSI可促进多种癌症的发生,包括结肠(15%)、胃(22%)、子宫内膜(20%~30%)和卵巢(12%),其中有45%~60%不响应免疫检查点封锁.因此,MSI型肿瘤需要新的治疗方法.研究人员猜测由MSI导致的基因组缺陷能与其他基因的失活形成合成致死关系,协同杀死癌细胞. | Chan EM Shibue T McFarland JM | 2019 | 国际老年医学杂志2019，40，6： | 3 |
| 2 | Fluorescent Superlattices of Gold Nanoparticles:A New Class of Functional Materials显示文摘Fluorescent three-dimensional(3-D)superlattices of dansyl glutathione protected gold nanoparticles,with potential applications in molecular detection,have been synthesized at an air/water interface by controlling the pH of the nanoparticle suspension.The number of fluorophores per nanoparticle was calculated to be~127.Morphologies of the superlattice crystals were examined using scanning electron microscopy(SEM).Most of the crystals observed were triangular in shape.High-resolution transmission electron microscopy(HRTEM)and small angle X-ray scattering(SAXS)were used to study the packing of nanoparticles in these crystals.Both these studies showed that the nanoparticles were arranged in a face-centered cubic(fcc)pattern with a particle-particle distance(center-center)of~10.5 nm.Evolution of the crystal morphologies with time was also examined.The fluorescence properties of these triangles were studied using confocal fluorescence imaging and confocal Raman mapping,which were in good agreement with the morphologies observed by SEM.The superlattice exhibits near-infrared(NIR)absorption in the range 1100-2500 nm.Easy synthesis of such functional nanoparticle-based solids makes it possible to use them in novel applications.We utilized the fluorescence of dansyl glutathione gold superlattice crystals for the selective detection of bovine serum albumin(BSA),the major protein constituent of blood plasma,based on the selective binding of the naphthalene ring of the dansyl moiety with site I of BSA. | Edakkattuparambil Sidharth Shibu Madathumpady Abubaker Habeeb Muhammed Keisaku Kimura Thalappil Pradeep | 2009 | Nano Research2009，2，3： | 3 |
| 3 | Burn scar revision on the face显示文摘 | De Souza BA Adlard R Shibu M | 2002 | Dermatol Surg2002，28，8： | 1 |
| 4 | Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State显示文摘 | Wenjun Guo Zuzana Keckesova Joana Liu Donaher Tsukasa Shibue Verena Tischler Ferenc Reinhardt Shalev Itzkovitz Aurelia Noske Ursina Zürrer-H?rdi George Bell Wai Leong Tam Sendurai A. Mani Alexander van Oudenaarden Robert A. Weinberg | 2012 | Cell2012，，5： | 1 |
| 5 | Distinct EMT programs control normal mammary stem cells and tumour-initiating cells 显示文摘 | YE X TAM WL SHIBUE T | 2015 | Nature2015，525，7568： | 1 |
| 6 | Enzymatic synthesis of pyruvic acid from acetaldehyde and carbon dioxide显示文摘 | Miyazaki M Shibue M Ogino K | 2001 | Chemical Communications2001，18，： | 1 |
| 7 | Walnut diet reduces accumulation of polyubiquitinated proteins and inflam- mation in the brain of ag~ rats 显示文摘 | Shibu M Poulose Donna F Bielinski Barbara Shukitt-Hale | 2013 | Journal of Nutritional Biochem- istry2013，24，： | 1 |
| 8 | Agroforestry for ecosystem services and environmental benefits显示文摘 | Shibu 7 | 2009 | Agroforest Sys- tem2009，76，： | 1 |
| 9 | Gas-phase Stability of Double-stranded Oligodeoxynucleotides and Their Noncovalent Complexes With DNAbinding Drugs as Revealed by Collisional Activation in an Ion Trap显示文摘 | Wan KX Gross ML Shibue T | 2000 | J Am Soc Mass Spectrom2000，11，5： | 1 |
| 10 | Effect of extrusion ratio on tensile properties of TiAl(Mn) produced by reactive sintering 显示文摘 | Furuyama T Kim M S | 1994 | Powder & Powder Metallurgy1994，41，2： | 1 |
| 11 | Exploring expression data: identification and analysis of coexpressed genes显示文摘 | Lattrie J H Semyon K Shibu Y | 1999 | Genome Research1999，，9： | 1 |
| 12 | New Process for Removal of Organics from Bayer Liquor显示文摘 | C Sato Y Yamada Y shibue | 1982 | Light Metals1982，，： | 1 |
| 13 | Annular pancreas detected in adults, diagnosed by endoscopic retrograde cholangiopancreatography: report of four cases 显示文摘 | YOGI Y SHIBUE T HASHIMOTO S | 1987 | Gastroenterol Jpn1987，22，1： | 1 |
| 14 | Metastatic colonization: settlement, ad- aptation and propagation of tumor cells in a foreign tissue envi- ronment显示文摘 | Shibue T Weinberg RA | 2011 | Semin Cancer Biol2011，21，2： | 1 |
| 15 | Agroforestry for ecosystem services and environmental benefits: an overview显示文摘 | Shibu Jose | 2009 | Agroforestry Systems2009，，1： | 1 |
| 16 | Exploring expression data:identification and analysis of coexpressed genes显示文摘 | Laurie J H Semyon K Shibu Y | 1999 | Genome Research1999，，9： | 1 |
| 17 | Annular pancreas detected in adults, diagnosed by endoscopic retrograde cholangiopancreatography: Report of four cases显示文摘 | Yoshikuni Yogi Tadashi Shibue Shuji Hashimoto | 1987 | Gastroenterologia Japonica1987，，1： | 1 |
| 18 | Measurement of the interfacial mechanical properties of a thin cermic coating on ductile substrates显示文摘 | SHIBU F S SHIAO M H | 1997 | Thin Solid Films1997，306，1： | 1 |
| 19 | Modeling cotton production response to shading in a pecan alley cropping system using CROPGRO显示文摘 | Diomides S Zamora Shibu Jose James W Jones | 2009 | Agroforestry Systems2009，76，2： | 1 |
| 20 | A study of the relation between intensity oscillations and magnetic field parameters in a sunspot: Hinode observations显示文摘We present properties of intensity oscillations of a sunspot in the photosphere and chromosphere using G band and Ca II H filtergrams from Hinode. Intensity power maps as function of magnetic field strength and frequency reveal reduction of power in the G band with an increase in photospheric magnetic field strength at all frequencies. In Ca II H, however, stronger fields exhibit more power at high frequencies, particularly in the 4.5–8.0 mHz band. Power distributions in different locations of the active region show that the oscillations in Ca II H exhibit more power compared to that of the G band. We also relate the power in intensity oscillations with different components of the photospheric vector magnetic field using near simultaneous spectro-polarimetric observations of the sunspot from the Hinode spectropolarimeter. The photospheric umbral power is strongly anti-correlated with the magnetic field strength and its line-of-sight component but there is a good correlation with the transverse component. A reversal of this trend is observed in the chromosphere except at low frequencies(ν≤ 1.5 mHz). The power in sunspot penumbrae is anti-correlated with the magnetic field parameters at all frequencies(1.0 ≤ν≤ 8.0 mHz) in both the photosphere and chromosphere, except that the chromospheric power shows a strong correlation in the frequency range 3–3.5 mHz. | A.Raja Bayanna Shibu K.Mathew Brajesh Kumar Rohan E.Louis P.Venkatakrishnan | 2014 | Research in Astronomy and Astrophysics2014，14，11： | 1 |
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