|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Renin angiotensin system in liver diseases: Friend or foe?显示文摘In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. | Ana Cristina Simoes e Silva Aline S Miranda Natália P Rocha Antonio L Teixeira | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 2 | 母猪妊娠期营养对窝产仔猪初生重整齐度的影响显示文摘母猪窝产仔猪初生重整齐度差导致生猪生产效率降低,研究母猪妊娠期间营养需求满足母猪和胎儿营养需要对提高生猪生产效率和增加窝产仔猪初生重的整齐度具有重要意义。然而,母猪妊娠期间营养水平对仔猪初生重整齐度影响的报道很少。本文分析影响仔猪初生重差异的因素及其机制,旨在为寻找提高窝产仔猪整齐度的营养战略提供帮助。 | Campos P H Silva B A Donzele J L 陈琳 龚新明 李君荣 | 2012 | 养猪2012，，5： | 11 |
| 3 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 4 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 5 | Effect of calcium hydroxide on bacterial endotoxin in vivo 显示文摘 | Silva L Nelson Filho P Leonardo MR | 2002 | J Endod2002，28，2： | 1 |
| 6 | Potassium permanganate oxidation of phenanthrene and pyrene in contaminated soils显示文摘 | Silva P T de souza e Silva V L Neto B B | 2009 | Journal of Hazardous Materials2009，168，： | 1 |
| 7 | The role of major histocompatibility complex alleles in the susceptibility of Brazi-lian patients to develop the myogenic type of Graves' orbitopathy显示文摘 | Akaishi P M Cruz A A Silva F L | 2008 | Thyroid2008，18，4： | 1 |
| 8 | Online topology determination and bad data suppression in power system operation using artificial neural networks显示文摘 | Souza J C S Silva A M L d Silva A P A d | 1998 | IEEE Transactions on Power Systems1998，13，3： | 1 |
| 9 | Soil physical quality of aBrazilian Oxisol under two tillage systems using the least limiting waterrange approach显示文摘 | TORMENA C A DA SILVA A P LIBARDI P L | 1999 | Soil&Tillage Research1999，52，： | 1 |
| 10 | Parametric Study of Adhesive Joints with Composites 显示文摘 | NETO J A B P CAMPILHO R D S G DA SILVA L F M | 2012 | International Journal of Adhesion and Adhesives2012，，： | 1 |
| 11 | 查看详情显示文摘 | Baur M Fedorov A Steffen L Filipp S Silva M P Wallraff A | | 0，，： | 1 |
| 12 | The effect of colchicine on liver function tests and hepatic fibrosis in patients with chronic active hepatitis:a study of 3 cases(author's transl)显示文摘 | Leandro P Ade O e Silva A BrandSo J F Saldanha L B Pontes J F | 2013 | Arquivos de Gastroenterologia2013，15，3： | 1 |
| 13 | Analytical models of adhesively bonded joints-Part I:literature survey显示文摘 | da Silva L F M das Neves P J C Adams R D | 2009 | International Journal of Adhesion and Adhesives2009，29，3： | 1 |
| 14 | Comprehensive two-dimensional gas chromatography/mass spectrometric analysis of pepper voatiles显示文摘 | Cardeal Z L Gomes da Silva M D Marriott P J | 2006 | Rapid Commun Mass Spectrom2006，20，： | 1 |
| 15 | Towards property oriented testing 显示文摘 | MACHADO P D L SILVA D A MOTA A C | 2007 | Electrical Notes in Theoretical Computer Science2007，184，： | 1 |
| 16 | Active learning paradigms for CBIR systems based on optimum-path forest classification 显示文摘 | da SILVA A T FALC?O A X MAGALH?ES L P | 2011 | Pattern Recognition2011，44，12： | 1 |
| 17 | Effect of calcium hydroxide on bacterial endotoxin in vivo显示文摘 | Silva L Nelson-Filho P Leonardo MR | 2002 | J Endod2002，28，2： | 1 |
| 18 | Radiographics Pattern Recognition of Welding Defects Using Linear Classifiers显示文摘 | R R da Silva M H S Siqueira L P Caloba etc | 2001 | Insight2001，，10： | 1 |
| 19 | Amazon drought and its implications for forest flammability and tree growth : a basin-wide analysis 显示文摘 | NEPSTAD D LEFEBVRE P SILVA U L D | 2004 | Global Change Biology2004，10，： | 1 |
| 20 | Phytoplankton biomass is mainly controlled by hydrology and phosphorus concentrations in tropical hydroelectric reservoirs 显示文摘 | Rangel L M Silva L H S Rosa P | 2012 | Hydrobiologia2012，693，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员