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| 1 | Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test显示文摘AIM:To study intestinal permeability(IP) and its relationship to the disease activity in patients with inflammatory bowel diseases(IBD)-Crohn's disease(CD) and ulcerative colitis(UC).METHODS:Fifty-eight patients with active IBD(32 with CD and 26 with UC) and 25 healthy controls consented to participate in the study.The clinical activity of CD was estimated using the Crohn's Disease Activity Index(CDAI),and the endoscopic activity of UC using the Mayo scoring system.IP was assessed by the rise in levels of iohexol,which was administered orally(25 mL,350 mg/mL) 2 h after breakfast.Three and six hours later serum(SIC mg/L) and urine(UIC g/mol) iohexol concentrations were determined by a validated HPLC-UV technique.RESULTS:In the CD group,SIC values at 3 h(2.95 ± 2.11 mg/L) and at 6 h after ingestion(2.63 ± 2.18 mg/L) were significantly higher compared to those of healthy subjects(1.25 ± 1.40 mg/L and 1.11 ± 1.10 mg/L,respectively,P < 0.05).UIC(g/mol) values were also higher in patients,but the differences were significant only for UIC at 6 h.Significant positive correlation(P < 0.05) was found between the CDAI and IP,assessed by SIC at 3 h(r = 0.60) and 6 h(r = 0.74) after the ingestion.In comparison to controls,SIC and UIC of UC patients were higher in the two studied periods,but the differences were significant at 6 h only.Significantly higher values of SIC(P < 0.05) were found in patients with severe endoscopic activity of UC compared to those of patients with mild and moderate activity(3.68 ± 3.18 vs 0.92 ± 0.69 mg/L).CONCLUSION:Serum levels of iohexol at 3 h and 6 h after its ingestion reflect increased IP,which is related to the disease activity in patients with IBD. | Vanya A Gerova Simeon G Stoynov Dimitar S Katsarov Dobrin A Svinarov | 2011 | World Journal of Gastroenterology2011，17，17： | 6 |
| 2 | Phenothiazines inhibit hepatitis C virus entry, likely by in- creasing the fluidity of cholesterol-rich membranes显示文摘 | Chamouu-Emanuelli A M Pecheur E I Simeon R L | 2013 | Antimi- crob Agents Chemother2013，57，6： | 1 |
| 3 | Utility of ITS sequence data for phylogenetic reconstruc- tion of Itatlian Querces spp 显示文摘 | Bellarosa R Simeone M C Papini A | 2005 | Mol Phylogenet Evol2005，34，2： | 1 |
| 4 | Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases显示文摘 | Lipton A Theriault RL Hortobagyi GN Simeone J Knight RD Mellars K Reitsma DJ Heffernan M Seaman JJ | | 0，，： | 1 |
| 5 | Cloning and characterization of two members of the vertebrate Dlx gene family显示文摘 | Simeone A Acampora D Pannese M | 1994 | Proc Nat Acad Sci1994，91，： | 1 |
| 6 | Aqueous tape casting processing of low dielectric constant cordierite-based glass-ceramics-Selection of binder显示文摘 | MEI Sen YANG Juan XU Xin Sandra Q Simeon A Ferreirajose M F | 2006 | J Euro Ceram Soc2006，26，12： | 1 |
| 7 | Nested expressiondomains of four homeobox genes in developing rostral brain 显示文摘 | Simeone A Acampora D Gulisano M | 1992 | Nature1992，358，6388： | 1 |
| 8 | Aldosterone-indueed activation of signaling pathways requires ac- tivity of angiotensin type la receptors显示文摘 | Lemarie CA Simeone SM Nikonova A | 2009 | Circ Res2009，105，9： | 1 |
| 9 | Surgical treatment of adrenal metastasis from renal cell carcinoma: a single-centre experience of 45 patients显示文摘 | ANTONELLI A COZZOLI A SIMEONE C | 2006 | BJU Int2006，97，3： | 1 |
| 10 | Ergodic and outage performance of fading broadcast channels with 1- bit feedback显示文摘 | Simeone O Somekh O Haimovich A M | 2010 | Vehicular Technology2010，59，3： | 1 |
| 11 | Surgical treatment of ureteral obstruction from edometriosis:our experience with thirteen cases显示文摘 | Antonelli A Simeone C Frego E | 2004 | Int Urogynecol Jpelvic Floor Dysfunct2004，15，： | 1 |
| 12 | Genetic map- ping of polyphenol oxidase in tetraploid wheat显示文摘 | Simeone R Pasqualone A Clodoveo M L | 2002 | Cell Mol Biol- ogy Letters2002，7，： | 1 |
| 13 | Soluble interleukin-2 receptor in stage Ⅰ-Ⅲ melanoma显示文摘 | Ottaiano A Leonardi E Simeone E | 2006 | Cytokine2006，33，3： | 1 |
| 14 | Surgical treatment of adrenal metastasis from renal cell carcinoma: a single-centre experience of 45 patients显示文摘 | Antonelli A Cozzoli A Simeone C | 2006 | BJU Int2006，97，3： | 1 |
| 15 | Herniated lumbar disc in patients over the age of fifty显示文摘 | An HS Vaccaro A Simeone FA | 1990 | J Spinal Disord1990，3，2： | 1 |
| 16 | Efficacy of liposomal daunorubicin and cytarabine as reinduction chemotherapy in relapsed acute lymphoblastic leukaemia despite expression of multidrug resistance-related proteins显示文摘 | Candoni A Michelutti A Simeone E | 2006 | Eur J Haematol2006，77，4： | 1 |
| 17 | Mechanical circulatory support:devices,outcomes and complications显示文摘 | Milano C A Simeone A A | 2013 | Heart Fail Reviews2013，18，1： | 1 |
| 18 | Clinical aspects and surgical treatment of urinary tract endometriosis: our experience with 31 cases显示文摘 | Antonelli A Simeone C Zani D | 2006 | Eur Urol2006，49，： | 1 |
| 19 | Genetic mapping of polyphenol oxidase in tetraploid wheat 显示文摘 | Simeone R Pasqualone A Clodoveo M L | 2002 | Cellular Molecular Biology Letters2002，7，： | 1 |
| 20 | Functional gastrointesti-nal disorders in children: An Italian prospective survey显示文摘 | MIELE E SIMEONE D MARINO A | 2004 | Pediat-rics2004，114，1： | 1 |
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