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| 1 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 2 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 3 | Direct continous method for monitoring biofilm infection in a mouse model显示文摘 | Kadurugamuwa JL Sin L Albert E | 2003 | Infec Immun2003，71，2： | 1 |
| 4 | Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis 显示文摘 | Sugimoto K Koh E Sin HS Maeda Y | 2009 | J Hum Genet2009，54，8： | 1 |
| 5 | IC-colorings and IC-indices of graphs 显示文摘 | SALEHI E SIN MIN LEE KHATIRINEJAD M S | 2005 | Discrete Mathematics2005，299，8： | 1 |
| 6 | The year in cardiology 2013:Valvular heart disease(focus on catheter-based interventions)显示文摘 | Grube E Sinning JM Vahanian A | 2014 | Eur Heart J2014，35，8： | 1 |
| 7 | Direct continuous method for monitoring biofilm infection in a mouse model显示文摘 | Kadurugamuwa JL Sin L Albert E | 2003 | Infect Immun2003，71，2： | 1 |
| 8 | A state-of-the-art review of parallel machine scheduling research显示文摘 | Cheng T C E Sin C C S | 1990 | European Journal of Operational Research1990，47，3： | 1 |
| 9 | Hypothalamic pituitary testicular axis function in endurance trained males显示文摘 | Hackney A C Sinning W E Bruot B C | 1990 | Iht J Sports Med1990，11，4： | 1 |
| 10 | Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease显示文摘 | Sin DD Lacy P Ernest York E | 2004 | Am J Respir Crit Care Med2004，170，： | 1 |
| 11 | Effects of fluticasone on systemicmarkers of inflammation in chronic obstructive pulmonary disease显示文摘 | Sin DD Lacy P York E | 2004 | Am J Respir Crit Care Med2004，170，7： | 1 |
| 12 | The effects of wrestling training on reproductive hormones (AB)显示文摘 | Hackney A C Sinning W E | 1986 | Med Sci Sports Exerc1986，18，： | 1 |
| 13 | Toxicokinetics of dothiepin: 2 case reports 显示文摘 | ROELOFSEN E E WILHELM A J SIN JEWEL A | 2008 | Ther Drug Monit2008，30，5： | 1 |
| 14 | Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons tometabolic and oxidative stress显示文摘 | Liu D C Sin L Souza-Pivto D E | 2006 | Neuro Molecular Medicine2006，8，3： | 1 |
| 15 | Calculations of melting threshold energies of crystalline and amorphous materials due to pulsed-laser irradiation 显示文摘 | Ong C K Tan H S Sin E H | 1986 | Mater Sci Eng1986，79，11： | 1 |
| 16 | Heat-flow calculation of pulsed excimer ultraviolet laser's melting of amorphous and crystalline silicon surfaces 显示文摘 | Ong C K Tan H S Sin E H | 1986 | J Opt Soc Am B1986，3，5： | 1 |
| 17 | Triptolide induced cytotoxic effects on human promyelocytic leukemia,T cell lymphoma and human hepatocellular carcinoma cell lines显示文摘 | Chan E W Cheng S C Sin F W | 2001 | Toxicol Lett2001，122，1： | 1 |
| 18 | Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis显示文摘 | SUGIMOTO K KOH E SIN H S | 2009 | J Hum Genet2009，54，8： | 1 |
| 19 | Significance of settling model structures and parameter subsets in modelling WWTPs under wet-weather flow and filamentous bulking conditions显示文摘 | Ramin E Sin G Mikkelsen P S | 2014 | Water Res2014，63，7： | 1 |
| 20 | Hypothalamic pituitary testicular axis function in endurance trained males 显示文摘 | Hackney A C Sinning W E Bruot B C | 1990 | Int J Sports Med1990，11，4： | 1 |
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