|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Stereotactic body radiation therapy for non-small cell lung cancer:A review显示文摘Stereotactic body radiation therapy(SBRT) is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC). A literature search primarily based on PubMed electronic databases was completed in July 2018. Inclusion and exclusion criteria were determined prior to the search, and only prospective clinical trials were included. Nineteen trials from 2005 to 2018 met the inclusion criteria, reporting the outcomes of 1434 patients with central and peripheral early stage NSCLC. Patient eligibility,prescription dose and delivery, and follow up duration varied widely. Threeyears overall survival ranged from 43% to 95% with loco-regional control of up to 98% at 3 years. Up to 33% of patients failed distantly after SBRT at 3 years. SBRT was generally well tolerated with 10%-30% grade 3-4 toxicities and a few treatment-related deaths. No differences in outcomes were observed between conventionally fractionated radiation therapy and SBRT, central and peripheral lung tumors, or inoperable and operable patients. SBRT remains a reasonable treatment option for medically inoperable and select operable patients with early stage NSCLC. SBRT has shown excellent local and regional control with toxicity rates equivalent to surgery. Decreasing fractionation schedules have been consistently shown to be both safe and effective. Distant failure is common, and chemotherapy may be considered for select patients. However, the survival benefit of additional interventions, such as chemotherapy, for early stage NSCLC treated with SBRT remains unclear. | Kavitha M Prezzano Sung Jun Ma Gregory M Hermann Charlotte I Rivers Jorge A Gomez-Suescun Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 10 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Long-term outcomes of interventions for radiation-induced xerostomia:A review显示文摘Xerostomia, or dry mouth, is a significant problem affecting quality of life in patients treated with radiation therapy for head and neck cancer. Strategies for reduction of xerostomia burden vary widely, with options including: sialagogue medications, saliva substitutes, acupuncture, vitamins, hyperbaric oxygen,submandibular gland transfer, and acupuncture or associated treatments. In this review, we sought to evaluate long-term outcomes of patients treated with various interventions for radiation-induced xerostomia. A literature search was performed using the terms 'xerostomia' and 'radiation' or 'radiotherapy'; all prospective clinical trials were evaluated, and only studies that reported 1 year follow up were included. The search results yielded 2193 studies, 1977 of which were in English. Of those, 304 were clinical trials or clinical studies. After abstract review, 23 trials were included in the review evaluating the following treatment modalities: pilocarpine(three); cevimeline(one); amifostine(eleven);submandibular gland transfer(five); acupuncture like transcutaneous electrical nerve stimulation(ALTENS)(one); hyperbaric oxygen(one); and acupuncture(one). Pilocarpine, cevimeline, and amifostine have been shown in some studies to improve xerostomia outcomes, at the cost of toxicity. ALTENS has similar efficacy with fewer side effects. Submandibular gland transfer is effective but requires an elective surgery, and thus may not always be appropriate or practical.The use of intensity-modulated radiation therapy, in addition to dose deescalation in select patients, may result in fewer patients with late xerostomia,reducing the need for additional interventions. | Sung Jun Ma Charlotte I Rivers Lucas M Serra Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 4 |
| 4 | Transfusion-transmitted virus in association with hepatitis A-E viral infections in various forms of liver diseases in India显示文摘瞄准:描述播送输送的病毒(TTV ) 的流行与在在诺思 India.METHODS 的肝疾病的不同形式的肝炎 A-E 病毒的感染联合的感染:从一个总数的血清 137 个病人数,包括 37 有尖锐病毒的肝炎( AVH )的病人,有长期的病毒的肝炎( CVH )的 37 个病人,有肝硬变的 31 个病人和有暴发性的肝的失败( FHF )的 32 个病人,为 TTV-DNA 和肝炎 A-E 病毒的标记两个都被分析。肝炎 B (HBV ) 的存在,丙肝病毒(HCV ) 和肝炎 E 病毒(HEV ) 感染在不同的组在不同比例被检测。而且, TTV-DNA 同时在 100 健康供血者 also.RESULTS 被测试:任何一个都没病人有肝炎 A 病毒(HAV ) 和肝炎 D 病毒(HDV ) 感染。TTV-DNA 的全面流行与 FHF 与 AVH,有 CVH 的 18.9% 盒子,有肝硬化的 48.4% 盒子和 9.4% 盒子在 27.1% 情况中被检测。同时在 100 健康供血者测试的 TTV-DNA 显示出 27% 确实。在与另外的肝炎建立在 TTV 感染之间的一种关系上病毒的感染, TTV 在这些疾病组与 HBV, HCV 和 HEV 表明了合作感染。有中高音的 TTV 的关联在重量的单位铺平一没在感染 TTV 的病人表明高中高音水平,建议那 TTV 不引起严重的肝 damage.CONCLUSION:TTV 感染在印度在病人和健康个人两个都是流行的。然而,它没与另外的肝炎有任何重要关联病毒的感染,它也不与肝疾病在病人生产严重的肝损坏的一条证据。 | M Irshad Y Sharma I Dhar J Singh YK Joshi | 2006 | World Journal of Gastroenterology2006，12，15： | 3 |
| 5 | Sex chromosome associated satellite DNA: Evolution and conservation 显示文摘 | Singh L Purdom I F Jones K W | 1980 | Chromosome1980，79，： | 2 |
| 6 | Fluctuation of visual analog scale pain scores and opioid consumption before and after total hip arthroplasty显示文摘BACKGROUND Patients who undergo orthopedic procedures are often given excess opioid medication.Understanding the relationship between pain and opioid consumption following total hip arthroplasty(THA)is key to creating safe and effective opioid prescribing guidelines.AIM To evaluate the association between the quantity of opioid consumption in relation to pain scores both pre-and postoperatively in patients undergoing primary THA.METHODS We retrospectively reviewed patients who underwent primary THA from November 2018-May 2019 and answered both the visual analog scale(VAS)pain and opioid medication questionnaires pre-and postoperatively.Both surveys were delivered daily for 7-days before surgery through the first 30 postoperative days.Survey results were divided into preoperative,postoperative days 1-7,postoperative days 8-14,and postoperative days 15-30 for analysis.Mean opioid pill consumption and VAS pain scores in each time period were determined and compared to patients’preoperative status using hierarchical Poisson and linear regressions,respectively.RESULTS There were 105 patients included.Mean VAS pain scores were the highest preoperatively 7.41±1.72.However,VAS pain scores significantly declined in each successive postoperative category compared to preoperative scores:postoperative day 1-7(5.07±1.79;P<0.001),postoperative day 8-14(3.60±1.64;P<0.001),and postoperative day 15-30(3.15±1.63;P<0.001).Mean opioid pill consumption preoperatively was 0.68±1.29 pills.Compared to preoperative opioid consumption,opioid use was significantly greater between postoperative days 1-7(1.51±1.58;P=0.001)and postoperative days 8-14(1.00±1.27;P=0.043).Opioid consumption declined below preoperative levels between postoperative days 15-30(0.35±0.72;P=0.160)which correlates with a VAS pain score of 3.15.CONCLUSION All patients experienced significant benefit and pain relief from having undergone THA.Average postoperative opioid consumption decreased below preoperative consumption between postoperative days 15-30,which was associated with a VAS pain score of 3.15.These results can be used to appropriately guide opioid prescribing practices and set patient expectations regarding pain management following THA. | Vivek Singh Alex Tang Thomas Bieganowski Utkarsh Anil William Macaulay Ran Schwarzkopf Roy I Davidovitch | 2022 | World Journal of Orthopedics2022，13，8： | 2 |
| 7 | Current status of multidrug resistant tuberculosis in a tertiary care hospital of East Delhi显示文摘 | T Sagar N Singh B Kashyap I Kaur | 2013 | Journal of Postgraduate Medicine2013，，3： | 2 |
| 8 | 改良搅拌摩擦焊修复汽车保险杠显示文摘本文研究了改良搅拌摩擦焊(MFSW)修复热塑性汽车保险杠。聚酰胺(PA6)复合材料常被用于改良搅拌摩擦焊中连接丙烯腈丁二烯苯乙烯(ABS)复合材料。为保证有效范围内的熔体流动特性,对不同的热塑性塑料进行了处理。然后,通过螺杆挤压制备了用于熔融沉积建模(FDM)过程的原料长丝。最后,为改良搅拌摩擦焊制备了基于PA6的3D打印耗材快速模具(RT),并对制备的接头进行了弯曲、硬度、形态和热性能测试。结果表明,在1400 r/min、50 mm/min横向速度和3 mm深度下焊接的样品力学强度最大,在1000 r/min、30 mm/min横向速度和2 mm深度下焊接的样品力学强度最小,该结果与热成像和显微结果一致。 | Ranvijay KUMAR Rupinder SINGH I P S AHUJA | 2020 | Journal of Central South University2020，27，8： | 2 |
| 9 | Primary small cell neuroendocrine carcinoma of urinary bladder: an uncommon entity to be recognized显示文摘 | Nabi G Singh I Ansari MS | 2001 | Int Urol Nephrol2001，33，： | 2 |
| 10 | Identification of human brain tumour initiating ceils 显示文摘 | SINGH S K HAWKINS C CLARKE I D | 2004 | Nature2004，432，7015： | 1 |
| 11 | Parallel EFG algorithm for heat transfer problems 显示文摘 | Singh I V Jain P K | 2005 | Advances in Engineering Software2005，36，8： | 1 |
| 12 | Identification of human brain tumour initiating cells显示文摘 | SINGH S K HAWKINS C CLARKE I D | 2004 | Nature2004，432，7015： | 1 |
| 13 | Identification of a cancer stem cell in human brain tumors显示文摘 | Singh S K Clarke I D Terasaki M | 2003 | Cancer Res2003，63，18： | 1 |
| 14 | Nonlinear behavior of soft clays during cyclic loading 显示文摘 | IDRISS I M DOBRY R SINGH R D | 1978 | Journal of Soil Mechanics and Foundation1978，104，12： | 1 |
| 15 | Distribu- tion of Giardia duodenalis genotypes and subgenotypes in raw urban wastewater in Milwaukee, Wisconsin显示文摘 | SULAIMAN I M JIANG Jian-lin SINGH A | 2004 | Appl Environ Microbiol2004，70，6： | 1 |
| 16 | Assessment and rationalizationof genetic diversity of Papua New Guinea taro(Colocasia esculenta)using SSR DNA fingerprinting显示文摘 | Singh D Mace E S Godwin I D | 2008 | Genetic Resources and CropEvolution2008，55，6： | 1 |
| 17 | Grain size and geochemical partitioning of heavy metals in sediments of the Damodar River--a tributary of the lower Ganga, India显示文摘 | Singh A K Hasnain S I Banerjee D K | 1999 | Environmental geology1999，39，1： | 1 |
| 18 | Productivity,competition indices and soil fertility changes of Bt cotton(Gossypium hirsutum)-groundnut(Arachis hypogaea) intercropping system using different fertility levels显示文摘 | Singh R J Ahlawat I P S | 2011 | Indian Journal of Agricultural Sciences2011，81，7： | 1 |
| 19 | Problems with reconciling density functional theory calculations with experiment in ferropnictides 显示文摘 | Mazin I I Johannes M D Boeri L Koepernik K Singh D J | 2008 | Plays Rev B2008，78，08： | 1 |
| 20 | Higher Body Mass Index Is Not Associated with Worse Pain Outcomes After Primary or Revision Total Knee Arthroplasty (TKA) 显示文摘 | Jasvinder A Singh S Gabriel I)(3 | 2011 | J Arthroplasty2011，26，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员