|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endoscopic ultrasound:It’s accuracy in evaluating mediastinal lymphadenopathy? A meta-analysis and systematic review显示文摘AIM:To evaluate the accuracy of endoscopic ultrasound (EUS), EUS-fine needle aspiration (FNA) in evaluating mediastinal lymphadenopathy. METHODS:Only EUS and EUS-FNA studies confirmed by surgery or with appropriate follow-up were selected. Articles were searched in Medline, Pubmed, and Cochrane control trial registry. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratios. Pooling was conducted by both Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS:Data was extracted from 76 studies (n = 9310) which met the inclusion criteria. Of these, 44 studies used EUS alone and 32 studies used EUS-FNA. FNA improved the sensitivity of EUS from 84.7% (95% CI:82.9-86.4) to 88.0% (95% CI:85.8-90.0). With FNA, the specificity of EUS improved from 84.6% (95% CI:83.2-85.9) to 96.4% (95% CI:95.3-97.4). The P forchi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION:EUS is highly sensitive and specific for the evaluation of mediastinal lymphadenopathy and FNA substantially improves this. EUS with FNA should be the diagnostic test of choice for evaluating mediastinal lymphadenopathy. | Srinivas R Puli Jyotsna Batapati Krishna Reddy Matthew L Bechtold Jamal A Ibdah Daphne Antillon Shailender Singh Mojtaba Olyaee Mainor R Antillon | 2008 | World Journal of Gastroenterology2008，14，19： | 10 |
| 2 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 3 | Immunotherapy and therapeutic vaccines in prostate cancer: an update on current strategies and clinical implications显示文摘在最近的年里,免疫疗法为前列腺癌症的治疗作为可行、吸引人的策略出现了。当有指向免疫系统的多重方法时,治疗学的癌症疫苗和有免疫力的检查点禁止者在迟了阶段的临床的试用是很成功的。为无征状或最低限度地征兆的变形前列腺癌症的 sipuleucel-T 的里程碑食物药品管理局赞同与癌症疫苗 PSA 得信佳和有免疫力的检查点禁止者 ipilimumab 为进行中的阶段 III 试用作准备。没有短期的变化,这些基于免疫者的治疗的一个普通特征是改进全面幸存的外观。这类效果看起来由于肿瘤生长率动力学,激活的免疫系统在施加减缓网络肿瘤生长的经常的 immunologic 压力的调整。新兴的数据建议为癌症疫苗的临床的试用的理想的人口是有更低的肿瘤体积和更少的好攻击的疾病的病人。把免疫疗法与标准治疗相结合的联合策略被显示了扩充有免疫力的反应和临床的利益。 | B Harpreet Singh James L Gulley | 2014 | Asian Journal of Andrology2014，16，3： | 6 |
| 4 | Influence of Biochars on Nitrous Oxide Emission and Nitrogen Leaching from Two Contrasting Soils显示文摘 | Singh Bhupinder Pal Hatton Blake J Singh Balwant Cowie Annette L Kathuria Amrit | 2010 | Journal of Environmental Quality2010，，4： | 4 |
| 5 | EXPERIMENTAL AND NUMERICAL INVESTIGATION OF BUBBLE AUGMENTED WATERJET PROPULSION显示文摘This contribution presents experimental and numerical investigations of the concept jet propulsion augmentation using bubble injection. A half-3D (D-shaped cylindrical configuration to enable optimal visualizations) divergent-convergent nozzle was designed, built, and used for extensive experiments under different air injection conditions and thrust measurement schemes. The design, optimization, and analysis were conducted using numerical simulations. The more advanced model was based on a two-way coupling between an Eulerian description of the flow field and a Lagrangian tracking of the injected bubbles using our Surface Averaged Pressure (SAP) model. The numerical results compare very favorably with nozzle experiments and both experiments and simulations validation the thrust augmentation concept. For a properly designed nozzle and air injection system, air injection produces net thrust augmentation, which increases with the rate of bubble injection. Doubling of thrust was measured for a 50% air injection rate. This beneficial effect remains at 50% after account for liquid pump additional work to overcome increased pressure by air injection. | CHOI Jin-Keun SINGH Sowmitra HSIAO Chao-Tsung CHAHINE Georges L | 2012 | Journal of Hydrodynamics2012，24，5： | 3 |
| 6 | Sex chromosome associated satellite DNA: Evolution and conservation 显示文摘 | Singh L Purdom I F Jones K W | 1980 | Chromosome1980，79，： | 2 |
| 7 | Phyototoxicity of ALS inhibitors is not due to accumulation of 2-ketobutyrate and/or 2-aminobutyrate 显示文摘 | Shaner D L and Singh B K | 1993 | Plant Phy1993，103，： | 2 |
| 8 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 9 | 中国农业产值优化组合预测研究显示文摘运用回归预测法与灰色系统预测法分别对中国农业总产值进行预测,再根据两种方法的误差确定优化组合预测模型的权重,通过优化组合方法对两种预测方法结果进行信息综合。结果表明,优化组合模型综合预测方法具有相对合理性、可行性和实用性,可为中国农业经济发展规划及管理决策提供科学依据。 | 朱春江 SINGH Surendra P COMER Sammy L | 2013 | 湖北农业科学2013，52，23： | 2 |
| 10 | Influence of Biochars on Nitrous Oxide Emission and Nitrogen Leaching from Two Contrasting Soils显示文摘 | Singh Bhupinder Pal Hatton Blake J Singh Balwant Cowie Annette L Kathuria Amrit | 2010 | Journal of Environmental Quality2010，，4： | 2 |
| 11 | Measurement of the intestinal permeability in chronic kidney disease显示文摘AIM: To evaluate methods measuring the intestinal permeability in chronic kidney disease(CKD) and clarify whether there is an increased intestinal permeability in CKD.METHODS: We reviewed the literature in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis(PRISMA) protocol and performed a systematic literature search through MEDline and EMBASE. All controlled trials and cohort studies using non-invasive methods to assess intestinal permeability in CKD patients were included. Excluded were: Conference abstracts and studies including patients younger than 18 years or animals. From the included studies we summarized the used methods and their advantages and disadvantages. For the comparison of their results we divided the included studies in two categories based on their included patient population, either assessing the intestinal permeability in mild to moderate CKD patients or in end stage renal disease(ESRD) patients. Results were graphically displayed in two plots, one comparing the intestinal permeability in mild to moderate CKD patients to healthy controls and one comparing the intestinal permeability in ESRD patients to healthy controls. RESULTS: From the 480 identified reports, 15 met our inclusion criteria. Methods that were used to assess the intestinal permeability varied from markers measured in plasma to methods based on calculating the urinary excretion of an orally administered test substance. None of the applied methods has been validated in CKD patients and the influence of decreased renal function on the different methods remains unclear to a certain extent. Methods that seem the least likely to be influenced by decreased renal function are the quantitative PCR(qPCR) for bacterial DNA in blood and D-lactate. Considering the results published by the included studies; the studies including patients with mild to moderate CKD conducted conflicting results. Some studies did report an increase in intestinal permeability whilst other did not find a significant increased permeability. However, despite the variety in used methods among the different studies, all studies measuring the intestinal permeability in ESRD point out a significant increased intestinal permeability. Results should nevertheless be interpreted with caution due to the possible influence of a decreased glomerular filtration rate on test results.CONCLUSION: The intestinal permeability in CKD:(1) could be measured by qPCR for bacterial DNA in blood and D-lactate; and(2) seems to be increased in ESRD. | Matty L Terpstra Ramandeep Singh Suzanne E Geerlings Frederike J Bemelman | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 12 | Aspergillus infections in transplant recipients 显示文摘 | Singh N Paterson D L | 2005 | Clin Microbiol Rev2005，18，1： | 1 |
| 13 | Demonstration of schottky barrier NMOS transistors with erbium silicided source/drain and silicon nanowire channel 显示文摘 | TAN E J PEY K L SINGH N | 2008 | IEEE Elec Dev Lett2008，29，10： | 1 |
| 14 | Oxidized LDL through LOX2-1 increases the expression of angiotensin converting enzyme in human coronary artery endothelial cells 显示文摘 | Li D Singh R M Liu L | 2003 | Cardiovasc Res2003，57，1： | 1 |
| 15 | Hydrological sensitivity of a large Himalayan basin to climate change显示文摘 | Singh P Bengtsson L | 2004 | Hydrological Processes2004，18，13： | 1 |
| 16 | Contingent gene regulatory networks and B cell fate specification显示文摘 | Singh H Medina K L Pongubala J M | 2005 | Proc Natl Acad Sci2005，102，： | 1 |
| 17 | Response of a grassland cactus to frequency and size of rainfall events in a North American shortgrass steppe显示文摘 | Dougherty R L Lauenroth W K Singh J S | 1996 | Journal of Ecology1996，84，： | 1 |
| 18 | Transcription factors in plant defense and stress responses 显示文摘 | Singh K Foley RC & Onate - Sanchez L | 2002 | Curr Opin Plant Biol2002，5，： | 1 |
| 19 | Comprehensive evidence-based guidelines for interventional techniques in the management of chronic spinal pain 显示文摘 | Manchikanti L Boswell MV Singh V | 2009 | Pain Physician2009，12，4： | 1 |
| 20 | Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms显示文摘 | Singh P K Schaefer A L Parsek M R | 2000 | Nature2000，407，6805： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员