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| 1 | Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma显示文摘AIM:To determine the expression and clinical significance of transcriptional intermediary factor 1 gamma (TIF1γ),Smad4 and transforming growth factor-beta (TGFβR) across a spectrum representing colorectal cancer (CRC) development.METHODS:Tissue microarrays were prepared from archival paraffin embedded tissue,including 51 colorectal carcinomas,25 tubular adenomas (TA) and 26 HPs,each with matched normal colonic epithelium.Immunohistochemistry was performed using antibodies against TIF1γ,Smad4 and TGFβ RⅡ.The levels of expression were scored semi-quantitatively (score 0-3 or loss and retention for Smad4).RESULTS:Overexpression of TIF1γ was detected in 5/26 (19%) HP;however,it was seen in a significantly higher proportion of neoplasms,15/25 (60%) TAs and 24/51 (47%) CRCs (P<0.05).Normal colonic mucosa,HP,and TAs showed strong Smad4 expression,while its expression was absent in 22/51 (43%) CRCs.Over-expression of TGFβ RⅡ was more commonly seen in neoplasms,13/25 (52%) TAs and 29/51 (57%) CRCs compared to 9/26 (35%) HP (P<0.05).Furthermore,there was a correlation between TIF1γ overexpression and Smad4 loss in CRC (Kendall tau rank correlation value=0.35,P<0.05).The levels of TIF1γ overexpression were significantly higher in stage Ⅲ than in stage Ⅰ and Ⅱ CRC (P<0.05).CONCLUSION:The findings suggest that over-expression of TIF1γ occurs in early stages of colorectal carcinogenesis,is inversely related with Smad4 loss,and may be a prognostic indicator for poor outcome. | Shilpa Jain Shashideep Singhal Franto Francis Cristina Hajdu Jin-Hua Wang Arief Suriawinata Yin-Quan wang Miao Zhang Elizabeth H Weinshel Fritz Francois Zhi-Heng Pei Peng Lee Ru-Liang Xu | 2011 | World Journal of Gastroenterology2011，17，35： | 3 |
| 2 | An evidence-based causative classification system for acute ischemie stroke 显示文摘 | Ay H Furie KL Singhal A | 2005 | Ann Neurol2005，58，： | 1 |
| 3 | Mathematical basis and validation of the full cavitation model 显示文摘 | Singhal A K Athavale M M Li H Y Jiang Y | 2002 | Journal of Fluids Engineering2002，，124： | 1 |
| 4 | Cell saver use in obstetrics显示文摘 | Malik S Brooks H Singhal T | 2010 | J Obstet Gynaecol2010，30，8： | 1 |
| 5 | Mathematical basis and validation of the full cavitation model显示文摘 | Singhal A K Athavale M M Li H Y | | 0，，： | 1 |
| 6 | Perparation of diafenthiuron, the correspoding carbodiimide 显示文摘 | C L Stevens G H Singhal | 1967 | J Org Chem1967，32，9： | 1 |
| 7 | Osteopontin and p53 expression are associated with tumor progression in a case of synchronous,bilateral,invasive mammary carcinomas显示文摘 | Tuck AB O'Malley FP Singhal H | 1997 | Arch Pathol Lab Med1997，121，6： | 1 |
| 8 | Mathematical Basis and Validation of the Full Cavitation Model 显示文摘 | SINGHAL A K ATHAVALE M M LI H Y | 2002 | Journal of Fluids Engineering2002，124，3： | 1 |
| 9 | Mathemati- cal basic and validation of full cavitation model显示文摘 | Singhal A K Athavale M M Li H etal | 2002 | Journal of Fluids Engineering2002，124，3： | 1 |
| 10 | Long- term study of port- site incisional hernia after laparoscopic procedures显示文摘 | Hussain A Mahmood H Singhal T | 2009 | JSLS2009，13，3： | 1 |
| 11 | Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival显示文摘 | Singhal H Bautista DS Tonkin KS | 1997 | Clin Cancer Res1997，3，4： | 1 |
| 12 | Mathematical basis and validation of the full cavitation model显示文摘 | Singhal A K Athavale M M Li H | 2002 | ASME Journal of Fluids Engineering2002，124，3： | 1 |
| 13 | Plasma Spraying of Lanthanum Chromite Films for Solid Oxide Fuel Cell Interconnection Application 显示文摘 | Kuo L J H Vora S D Singhal S C | 1997 | Journal of the American Ceramic Society1997，80，3： | 1 |
| 14 | Mathematical basis and validation of the full cavitations model显示文摘 | Athavale M M Li H Y | 2002 | ASME Journal of Fluids Engineering2002，124，： | 1 |
| 15 | Long-term study of portsite incisional hernia after laparoscopic procedures显示文摘 | Hussain A Mahmood H Singhal T | 2009 | JSLS2009，13，3： | 1 |
| 16 | Long-term study of pert-site ineisional hernia after laparoscopic procedures显示文摘 | Huaaain A Mahmood H Singhal T | 2009 | JSLS2009，13，3： | 1 |
| 17 | Mathemati- cal basis and validation of the full cavitation model 显示文摘 | Singhal A K Athavale M M Li H Y | 2002 | Journal of Fluids Engineering2002，124，： | 1 |
| 18 | Mathematical basis and validation of the full cavitation model显示文摘 | Singhal A K LI H Y Athavale M M | 2002 | Journal of Fluids Engineering2002，124，： | 1 |
| 19 | Mathematical Basis and Validation of the Full Cavitation Mode 显示文摘 | Singhal A K Athavale M M Li H | 2002 | Journal of Fluids Engineer- ing2002，124，3： | 1 |
| 20 | Antitumor immunity induced by laser immunotherapy and its adoptive transfer显示文摘 | Chen WR Singhal AK Liu H | 2001 | Cancer Res2001，61，： | 1 |
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