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| 1 | In vivo printing of growth factor-eluting adhesive scaffolds improves wound healing显示文摘Acute and chronic wounds affect millions of people around the world,imposing a growing financial burden on patients and hospitals.Despite the application of current wound management strategies,the physiological healing process is disrupted in many cases,resulting in impaired wound healing.Therefore,more efficient and easy-to-use treatment modalities are needed.In this study,we demonstrate the benefit of in vivo printed,growth factor-eluting adhesive scaffolds for the treatment of full-thickness wounds in a porcine model.A custom-made handheld printer is implemented to finely print gelatin-methacryloyl(GelMA)hydrogel containing vascular endothelial growth factor(VEGF)into the wounds.In vitro and in vivo results show that the in situ GelMA crosslinking induces a strong scaffold adhesion and enables printing on curved surfaces of wet tissues,without the need for any sutures.The scaffold is further shown to offer a sustained release of VEGF,enhancing the migration of endothelial cells in vitro.Histological analyses demonstrate that the administration of the VEGF-eluting GelMA scaffolds that remain adherent to the wound bed significantly improves the quality of healing in porcine wounds.The introduced in vivo printing strategy for wound healing applications is translational and convenient to use in any place,such as an operating room,and does not require expensive bioprinters or imaging modalities. | Kristo Nuutila Mohamadmahdi Samandari Yori Endo Yuteng Zhang Jacob Quint Tannin ASchmidt b Ali Tamayol Indranil Sinha | 2022 | Bioactive Materials2022，7，2： | 3 |
| 2 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 3 | The developmental gene Knotted-1 is a member of a maize homeobox gene family显示文摘 | Vollbrecht E Veit B Sinha N | 1991 | Nature1991，350，： | 1 |
| 4 | 显示文摘 | Morris D E Chandrachood M R Sinha A P B | 1991 | Physica C1991，175，： | 1 |
| 5 | Characterization of M-type barium hexagonal ferrite-based wide band microwave absorber显示文摘 | Meshram M R Agrawal N K Sinha B | 2004 | J Magn Magn Mater2004，，271： | 1 |
| 6 | Bcl-2 family members : dual regu- lators of apoptosis and autophagy显示文摘 | Levine B Sinha S Kroemer G | 2008 | Autophagy2008，4，5： | 1 |
| 7 | Teratogenic Effects of Ochratoxin A and Aflatoxin B1 Alone and in Combination on Post-Implantation Rat Embryos in Culture显示文摘 | Wangikar P B Sinha N Dwivedi P | | 0，，04： | 1 |
| 8 | Improved Production of Re- combinant Ovine Iuterferon-'r by Mut + Strain of Pichiapastoris Using an Optimized Methanol Feed Profile显示文摘 | Sinha J Plantz B A Zhang W | 2003 | Biotechnol Progr2003，19，3： | 1 |
| 9 | Assessment of partial nitrification reactor performance through microbial population shift using quinone profile, FISH and SEM显示文摘 | SINHA B ANNACHHATRE A P | 2007 | Bioresource Technology2007，98，18： | 1 |
| 10 | Differential oncogene expression and susceptibility to apoptosis in the hLlman leukemia HL- 60 cell lines- mplications for etoposide resistance显示文摘 | Eliot H E Bomer MN Sinha B K | 1995 | Anticancer Res1995，15，3： | 1 |
| 11 | Determination of current density distributions generated by electrical stimulation of the human cerebral cortex 显示文摘 | Nathan SS Sinha SR Gordon B | 1993 | Electroencephalogr Clin Neurophysiol1993，86，： | 1 |
| 12 | On patent licensing in spatial competition显示文摘 | Poddar S Sinha U B | 2004 | The Economic Record2004，80，2： | 1 |
| 13 | The shear of press-joining in cold-formed steel structures显示文摘 | Davies R Pedreschi R Sinha B | 1996 | Thin-Walled Structure1996，25，3： | 1 |
| 14 | X-ray and neutuon scattering from rough surfaces显示文摘 | Sinha S K Sirata E B Garoff S Stanley H B | 1988 | Phys Rev B1988，38，4： | 1 |
| 15 | Bcl-2 family members:dual regulators of apoptosis and autophagy显示文摘 | Levine B Sinha S Kroemer G | 2008 | Autophagy2008，4，5： | 1 |
| 16 | Phosphated issolving mi croorganisium in the rhizosphere and soil显示文摘 | Sundara Rao W V B Sinha M K | 1963 | Indian J Ag- tic Soi11963，33，4： | 1 |
| 17 | Effect of Eupatorium adenophorum Spreng, leaf extracts on the mustard aphid, Lipaphis crysimi Kalt: a scanning electron microscope study 显示文摘 | Dey S Sinha B Kalita J | 2005 | Microsc Res Techniq2005，66，1： | 1 |
| 18 | Synthesis of Silicon Nanowires and Novel Nano-Dendrite Structures显示文摘 | Gan B Zhou O | 2004 | J Nanopart Res2004，6，4： | 1 |
| 19 | Assessment of Partial Nitrification Reactor Performance through Microbial Population Shift Using Quinone Profile,FISH and SEM显示文摘 | Sinha B Annachhatre A P | 2007 | Bioresource Technology2007，98，18： | 1 |
| 20 | Maternal ante-natal parameters as predictors of persistent postnatal glucose intolerance:a comparative study between Afro-Caribbeans,Asians and Caucasians显示文摘 | Sinha B Brydon P Taylor RS | 2003 | Diabet Med2003，20，5： | 1 |
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