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| 1 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 2 | Serum arylesterase and paraoxonase activity in patients with chronic hepatitis显示文摘AIM: To investigate the relationship between serum paraoxonase (PON1), AST, ALT, GGT, and arylesterase (AE) activity alterations and the degree of liver damage in patients with chronic hepatitis.METHODS: We studied 34 chronic hepatitis patients and 32 control subjects, aged between 35 and 65 years,in the Department of Infection and Clinical Microbiology at the Firat University School of Medicine. Blood samples were collected from subjects between 8:00 and 10:00 a.m. following a 12-h fast. Baseline and salt-stimulated PON1 activities were measured by the hydrolysis of paraoxon. Phenyl acetate was used as the substrate and formed phenol was measured spectrophotometrically at 270 nm after the addition of a 10-fold diluted serum sample in AE activity measurements.RESULTS: The results of this investigation revealed that the levels of AE activity decreased from 132±52 to 94±36 (29%), baseline PON1 activity from 452±112 to 164±67 (64%), salt-stimulated PON1 activity from 746±394 to 294±220 (61%), HDL from 58.4±5.1 to 47.2±5.6(20%), triglyceride from 133±51.2 to 86±34.0 (35%),while a slight increase in the level of LDL (from 163±54.1 to 177.3±56.0; 9%) and significant increases in the levels of AST (from 29±9.3 to 98±44), ALP (from 57.2±13.1 to 91±38.1), ALT (from 27.9±3.32 to 89±19.1), GGT (from 24.3±2.10 to 94±48.2), total bilirubin (from 0.74±0.02 to 1.36±0.06; 84%) and direct bilirubin (from 0.18±0.01 to 0.42±0.04; 133%) were detected.However, the levels of albumin, total protein, cholesterol,and uric acid were almost the same in chronic hepatitis and the control subjects.CONCLUSION: Low PON1 and AE activity may contribute to the increased liver dysfunction in chronic hepatitis patients by reducing the ability of HDL to retard LDL oxidation and might be clinically useful for monitoring the disease of chronic hepatitis. | Suleyman Sirri Kilic Suleyman Aydin Nermin Kilic Fazilet Erman Suna Aydin Ilhami Celik | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 3 | Effects of dietary vitamin E on the quality of table eggs enriched with n-3 long-chain fatty acids 显示文摘 | Meluzzi A Sirri F Manfreda G | 2000 | Poult Sci2000，79，4： | 1 |
| 4 | The AgNOR proteins: qualitative and quantitative changes during the cell cycle 显示文摘 | SIRRI V ROUSSEL P HERNANDEZ - VERDUM D | 2000 | Micron2000，31，： | 1 |
| 5 | Costly search and mutual fund flows 显示文摘 | Sirri E R Tufano P | 1998 | Journal of Finance1998，，53： | 1 |
| 6 | Modified atmosphere packaging of hen table eggs: Effects on functional properties ofalbumen显示文摘 | Rocculi P Cocci E Sirri F | 2011 | Poultry Science2011，90，9： | 1 |
| 7 | Costly search and mutual fund flows 显示文摘 | Sirri E Tufano P | 1998 | Journal of Finance1998，53，5： | 1 |
| 8 | Costly search and mutual fund flows显示文摘 | Sirri E P Tufano | 1998 | Journal of Finance1998，53，5： | 1 |
| 9 | Costly Search and Mutual Fund Flows 显示文摘 | Sirri Erik R Tufano P | 1998 | Journal of Finance1998，，53： | 1 |
| 10 | The AgNOR proteins: qualitative and quantitative changes during the cell cycle显示文摘 | Sirri V Roussel P Herrandez-Verdun D | 2000 | micror2000，31，2： | 1 |
| 11 | Costly search and mutual funds flow显示文摘 | Sirri E P Tufano P | 1998 | The Journal of Finance1998，53，2： | 1 |
| 12 | FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse显示文摘 | Hentges KE Sirry B Gingeras AC | 2001 | Proc Natl Acad Sci U S A2001，98，13： | 1 |
| 13 | Effects of Dietary Vitamin E on the Quality of Table Eggs Enriched with n-3 Long-Chain Fatty Acids显示文摘 | Meluzzi A Sirri F Manfreda G | 2000 | Poulry Sci2000，79，： | 1 |
| 14 | Modified atmosphere packaging of hen table eggs:effects on functional properties of albumen显示文摘 | Rocculi P Cocci E Sirri F | 2011 | Poultry Science2011，90，9： | 1 |
| 15 | Polymorphisms of the methylenetetrahydrofolate reductase, vascular endothelial growth factor, endothelial nitric oxide synthase, monocyte chemoattractant protein-I and apolipoprotein E genes are not associated with carot- id intima-media thickness显示文摘 | Emin Alioglu Ugur Turk Sirri Cam | 2009 | Can J Cardiol2009，25，1： | 1 |
| 16 | Cosily Search and Mutual Fund Flows显示文摘 | SIRRI ERIN R TUFANO PETER | 1998 | The Journal of Finance1998，53，5： | 1 |
| 17 | Modified atmosphere packaging of hen table eggs:effects on functional properties of albumen显示文摘 | Rocculi P Cocci E Sirri F | 2011 | Poultry Science2011，90，9： | 1 |
| 18 | The quantity of nucleolar proteins nucleolin and protein B23 is related to cell doubling time in human cancer cells显示文摘 | Derenzini M Sirri V Trere D | | 0，，04： | 1 |
| 19 | and Peter Tufano,Costly Search And Mutual Fund Flows显示文摘 | Erik R | 1998 | Journal of Finance1998，，53： | 1 |
| 20 | Costly search and mutual fund flows显示文摘 | Sirri Erin R Tufano Peter | 1998 | The Journal of Finance1998，53，5： | 1 |
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