|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis C eradication with sofosbuvir leads to significant metabolic changes显示文摘AIM To assess the effect of sofosbuvir(SOF) based regimens on glycemic and lipid control.METHODS This is a retrospective analysis of hepatitis C virus(HCV)-infected patients treated and cured with a SOF regimen [SOF/ribavirin/interferon, SOF/simeprevir, or SOF/ledipasvir(LDV) ± ribavirin] from January 2014 to March 2015. Patients with hemoglobin A1C(HbA1C) and lipid panels within six months before and six months after therapy were identified and included in our study. Due to the known hemolytic effect of ribavirin, HbA1C was obtained a minimum of three months post-treatment for the patients treated with a ribavirin regimen. Medical history, demographics, HCV genotype, pre-therapy RNA, and liver biopsies were included in our analysis. The patients who started a new medication or had an adjustment of baseline medical management for hyper-lipidemia or diabetes mellitus(DM) were excluded from our analysis.RESULTS Two hundred and thirty-four patients were reviewed, of which 60 patients met inclusion criteria. Sixty-three point three percent were male, 26.7% were Caucasian, 41.7% were African American and 91.7% were infected with hepatitis C genotype 1. Mean age was 60.6 ± 6.7 years. Thirty-nine patients had HbA1C checked before and after treatment, of which 22 had the diagnosis of DM type 2. HbA1C significantly decreased with treatment of HCV(pretreatment 6.66% ± 0.95% vs posttreatment 6.14% ± 0.65%, P < 0.005). Those treated with SOF/LDV had a lower HbA1C response than those treated with other regimens(0.26% ± 0.53% vs 0.71% ± 0.83%, P = 0.070). Fifty-two patients had pre- and post-treatment lipid panels; there was a significant increase in low-density lipoprotein(LDL) and total cholesterol(TC) after treatment(LDL: 99.5 ± 28.9 mg/dL vs 128.3 ± 34.9 mg/dL, P < 0.001; TC: 171.6 ± 32.5 mg/dL vs 199.7 ± 40.0 mg/dL, P < 0.001). Pretreatment body-mass index(BMI) did not differ from post-treatment BMI(P = 0.684). CONCLUSION Eradication of HCV with a SOF regimen resulted in a significant drop in HbA1C and an increase in LDL and TC post therapy. | Amilcar L Morales Zachary Junga Manish B Singla Maria Sjogren Dawn Torres | 2016 | World Journal of Hepatology2016，8，35： | 2 |
| 2 | 老年高总胆固醇水平与痴呆风险降低相关 | Mielke M.M. Zandi P.P. Sjogren M. 陈海 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，9： | 2 |
| 3 | Gravitational Constraints on the Internal Structure of Ganymede显示文摘 | LAU E L SJOGREN W L, | 1996 | Nature1996，384，6609： | 1 |
| 4 | Decreased cerehrospinal fluid acetylchollnesterase in patients with subcortical ischemlc vascular dementia 显示文摘 | Wallin A Sjogren M Blennow K | 2003 | Dement Geriatr Cogn Disord2003，16，4： | 1 |
| 5 | The effect of vacuum - assisted closure therapy on the pig femoral artery vasomotor responses 显示文摘 | Wackonfors A Angelica M Sjogren J | 2004 | Wound Repair & Regeneration2004，12，2： | 1 |
| 6 | Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyrA and parC显示文摘 | Gibreel A Sjogren E Kaijser B | | 0，，12： | 1 |
| 7 | HPA axis acti- vation determined by the CRH challenge test in patients with few versus multiple episodes of treatment--refractory depression 显示文摘 | Ehnvall A Sjogren M Zachrisson OC | 2004 | Eur Arch Psychiatry Clin Neurosci2004，254，6： | 1 |
| 8 | Chromosome 9p21 genetic variation explains 13% of cardiovascular disease incidence but does not improve risk prediction显示文摘 | Gransbo K Almgren P Sjogren M | 2013 | J Int Med2013，274，3： | 1 |
| 9 | Blood flow responses in the peristernal thoracic wall during vacuum-assisted closure therapy显示文摘 | GUSTAFSSON R SJOGREN J | 2005 | Ann Thorac Surg2005，79，5： | 1 |
| 10 | Reversible antifouling effect of the cyclotide cycloviolacin O2 against barnacles显示文摘 | Goransson U Sjogren M Svangard E | 2004 | Journal of NaturalProducts2004，67，8： | 1 |
| 11 | Enteropathogenic Bacteria in Faecal Swabs of Young Children Fed on Lactic Acid-Fermented Cereal Gruels显示文摘 | KINGAMKONO R SJOGREN E SVANBERG U | 1999 | Epidemiology and Infection1999，122，： | 1 |
| 12 | Factors affecting the long-term results of endodontic treatment显示文摘 | Sjogren U Hagglund B Sundqvist G | 1990 | J Endod1990，16，10： | 1 |
| 13 | Development and calibra- tion of nonlinear algebraic models for terms in Rey- nolds stress transport equations 显示文摘 | Sjogren T Johansson A V | 2000 | Phys Fluids2000，12，： | 1 |
| 14 | Differences in cerebral extracellular response of interleukin-1beta,interleukin-6,and interleukin-10 after subarachnoid hemorrhage or severe head trauma in humans显示文摘 | Mellergard P Aneman O Sjogren F | 2011 | Neurosurgery2011，68，1： | 1 |
| 15 | The search for putative unifying genetic factors for components of the metabolic syndrome 显示文摘 | Sjogren M Lyssenko V Jonsson A | 2008 | Diabetologia2008，51，12： | 1 |
| 16 | Symptoms,vascular risk factors and blood-brain barrier function in relation to CT white-matter changes in dementia显示文摘 | Wallin A Sjogren M Edman A | 2000 | Eur Neurol2000，44，： | 1 |
| 17 | Occupational exposure to dust:inflammation and ischaemie heart disease显示文摘 | Sjogren B | 1997 | Occup Environ Med1997，54，： | 1 |
| 18 | Characteristics of collaboration in product innovation in the regional system of innovation of East Gothia显示文摘 | Edquist C Eriksson M L Sjogren H | 2002 | European Planning Studies2002，，5： | 1 |
| 19 | Osteoprotegerin mRNA is increased by interleukin-l alpha in the human osteosareoma cell line MG-63 and in human osteoblast-like cells显示文摘 | Vidal ON Sjogren K Eriksson BI | 1998 | Biochem Biophys Res Commun1998，248，3： | 1 |
| 20 | Retained drugeluting stents and recalcitrant chronic rhinosinusitis:A case report显示文摘 | SJOGREN P P PARKER N P BOYER H C | 2013 | Allergy&Rhinology2013，4，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员