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1Acid suppressive drugs and gastric cancer: A meta-analysis of observational studies显示文摘AIM: To evaluate the association between acid suppressive drug use and the development of gastric cancer. METHODS: A systematic search of relevant studies that were published through June 2012 was conducted using the MEDLINE (PubMed), EMBASE, and Cochrane Library databases. The search included observational studies on the use of histamine 2-receptor antagonists (H 2 RAs) or proton pump inhibitors and the associated risk of gastric cancer, which was measured using the adjusted odds ratio (OR) or the relative risk and 95%CI. An independent extraction was performed by two of the authors, and a consensus was reached. RESULTS: Of 4595 screened articles, 11 observational studies (n = 94558) with 5980 gastric cancer patients were included in the final analyses. When all the studies were pooled, acid suppressive drug use was associated with an increased risk of gastric cancer risk (adjusted OR = 1.42; 95%CI: 1.29-1.56, I2 = 48.9%, P = 0.034). The overall risk of gastric cancer increased among H 2 RA users (adjusted OR = 1.40; 95%CI: 1.24-1.59, I2 = 59.5%, P = 0.008) and PPI users (adjusted OR = 1.39; 95%CI: 1.19-1.64, I2 = 0.0%, P = 0.377). CONCLUSION: Acid suppressive drugs are associated with an increased risk of gastric cancer. Further studies are needed to test the effect of acid suppressive drugs on gastric cancer.Jeong Soo Ahn Chun-Sick Eom Christie Y Jeon Sang Min Park 2013World Journal of Gastroenterology2013,19,16:12
2Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment.Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng 2023Stroke & Vascular Neurology2023,8,1:2
3Living Donor Kidneys:Usefulness of Multi-Detector Row CT for Comp rehensive Evaluation显示文摘Jeong K Soo Y Heon J 2003Radiology2003,229,:1
4The rol of functional MR imaging in patients with ischemia in the visual cortex显示文摘 Chung TS Soo Y 2001AJNR Am J Neuroradiol2001,22,:1
5Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone显示文摘Cheng Y Wong RS Soo YO 2003N Engl J Med2003,349,:1
6New hybrid method for simultaneousimprovement of tensile and impact properties of carbon fiber reinforcedcomposites显示文摘Seong Y K Soo J B Jae R Y 2011Carbon2011,49,15:1
7A simple gold nanoparticle probes assay for identification of Mycobacterium tuberculosis and Mycobacterium tuberculosis complex from clinical specimens显示文摘Soo P C Horng Y T Chang K C 2009Mol Cell Probes2009,23,5:1
8A low complexity selected mapping scheme by use of time domain se-quence superposition technique for PAPR reduction in OFDM system显示文摘YANG L SOO K K SIU Y M 2008IEEE Transactions on Broadcast-ing2008,54,4:1
9Local structures around Mn luminescent centers in Mn-doped nanocrystals of ZnS显示文摘SOO Y L MING Z H HUANG S W 1994Phys Bev B1994,50,:1
10A generalized approach to the design of variable fractional-delay FIR digital filters 显示文摘Shu Jong J Y Pei Soo Chang 2008Signal Processing2008,88,6:1
11lnitial treatment of immune thrombocytopenic purpura with high-dose dexamethasone显示文摘CHENG Y WONG RS SOO YO 2003N Engl J Med2003,349,:1
12Resident perception of the impact of limited*stakes community-based casino gaming in mature gaming communities 显示文摘Soo K K Choong K L Yooshik Y 2008Tourism Management2008,29,4:1
13Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT-1080 human fibrosarcoma cells显示文摘Hee J Soo KB Ho Y 1996Cancer Ras1996,56,10:1
14An invertible frequency eigendomain transformation for masking-based subspace speech enhancement显示文摘Chang H Y Soo N K Susanto R 2005IEEE Singal Processing Letters2005,12,:1
15Initial treat-ment of immune thrombocytopenic purpura with high-dose dexamethasone显示文摘CHENG Y WONG R S SOO Y O 2003N Engl J Med2003,349,:1
16A cooperative multi- agent platform for invention based on patent document analysis and ontology显示文摘SOO V W LIN S Y YANG S Y 2006Expert Systems with Application2006,31,4:1
17The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in trans- forming growth factor-beta signaling 显示文摘Kim W Seok Kang Y Soo Kim J 2008Mol Biol Cell2008,19,5:1
18Biotechnol Bioeng 显示文摘Lee K G Park T J Soo S Y 2010107(4): 747-7512010,107,4:1
19Chordoma:review of clinicoradiological features and factors affecting survival显示文摘Soo M Y 2001Australas Radiol2001,45,4:1
20Different distribution pat terns of cerebral microbleeds in acute ischemic stroke patients with and without hypertension显示文摘Sun J Soo Y O Lam W W 2009Eur Neurol2009,62,:1
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