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| 1 | Helicobacter pylori in human health and disease:Mechanisms for local gastric and systemic effects显示文摘Helicobacter pylori(H. pylori) is present in roughly 50% of the human population worldwide and infection levels reach over 70% in developing countries. The infection has classically been associated with different gastro-intestinal diseases, but also with extra gastric diseases. Despite such associations, the bacterium frequently persists in the human host without inducing disease, and it has been suggested that H. pylori may also play a beneficial role in health. To understand how H. pylori can produce such diverse effects in the human host, several studies have focused on understanding the local and systemic effects triggered by this bacterium. One of the main mechanisms by which H. pylori is thought to damage the host is by inducing local and systemic inflammation. However, more recently, studies are beginning to focus on the effects of H. pylori and its metabolism on the gastric and intestinal microbiome. The objective of this review is to discuss how H. pylori has co-evolved with humans, how H. pylori presence is associated with positive and negative effects in human health and how inflammation and/or changes in the microbiome are associated with the observed outcomes. | Denisse Bravo Anilei Hoare Cristopher Soto Manuel A Valenzuela Andrew FG Quest | 2018 | World Journal of Gastroenterology2018，24，28： | 32 |
| 2 | Going beyond 1000000 resolved points in a Brillouin distributed fiber sensor: theoretical analysis and experimental demonstration显示文摘Distributed fiber sensing possesses the unique ability to measure the distributed profile of an environmental quantity along many tens of kilometers with spatial resolutions in the meter or even centimeter scale.This feature enables distributed sensors to provide a large number of resolved points using a single optical fiber.However,in current systems,this number has remained constrained to a few hundreds of thousands due to the finite signal-to-noise ratio(SNR)of the measurements,which imposes significant challenges in the development of more performing sensors.Here,we propose and experimentally demonstrate an ultimately optimized distributed fiber sensor capable of resolving 2100000 independent points,which corresponds to a one-orderof-magnitude improvement compared to the state-of-the-art.Using a Brillouin distributed fiber sensor based on phase-modulation correlation-domain analysis combined with temporal gating of the pump and time-domain acquisition,a spatial resolution of 8.3 mm is demonstrated over a distance of 17.5 km.The sensor design addresses the most relevant factors impacting the SNR and the performance of medium-to-long range sensors as well as of sub-meter spatial resolution schemes.This step record in the number of resolved points could be reached due to two theoretical models proposed and experimentally validated in this study:one model describes the spatial resolution of the system and its relation with the sampling interval,and the other describes the amplitude response of the sensor,providing an accurate estimation of the SNR of the measurements. | Andrey Denisov Marcelo A Soto Luc Thévenaz | 2016 | Light(Science & Applications)2016，5，1： | 11 |
| 3 | Influence of dissolved organic matter character on mercury incorporation by planktonic organisms: An experimental study using oligotrophic water from Patagonian lakes显示文摘Ligands present in dissolved organic matter(DOM) form complexes with inorganic divalent mercury(Hg2+) afecting its bioavailability in pelagic food webs. This investigation addresses the influence of a natural gradient of DOM present in Patagonian lakes on the bioaccumulation of Hg2+(the prevailing mercury species in the water column of these lakes) by the algae Cryptomonas erosa and the zooplankters Brachionus calyciflorus and Boeckella antiqua. Hg2+accumulation was studied through laboratory experiments using natural water of four oligotrophic Patagonian lakes amended with197Hg2+. The bioavailability of Hg2+was afected by the concentration and character of DOM. The entrance of Hg2+into pelagic food webs occurs mostly through passive and active accumulation. The incorporation of Hg2+by Cryptomonas, up to 27% of the Hg2+amended, was found to be rapid and dominated by passive adsorption,and was greatest when low molecular weight compounds with protein-like or small phenolic signatures prevailed in the DOM.Conversely, high molecular weight compounds with a humic or fulvic signature kept Hg2+in the dissolved phase, resulting in the lowest Hg2+accumulation in this algae. In Brachionus and Boeckella the direct incorporation of Hg from the aqueous phase was up to3% of the Hg2+amended. The dietary incorporation of Hg2+by Boeckella exceeded the direct absorption of this metal in natural water,and was remarkably similar to the Hg2+adsorbed in their prey. Overall, DOM concentration and character afected the adsorption of Hg2+by algae through competitive binding, while the incorporation of Hg2+into the zooplankton was dominated by trophic or dietary transfer. | María C.Diéguez Claudia P.Queimalios Sergio Ribeiro Guevara Mark Marvin-DiPasquale Carolina Soto Crdenas María A.Arribre | 2013 | Journal of Environmental Sciences2013，25，10： | 6 |
| 4 | Developing a Marker of exposure to xenoestrogen mixtures in human serum显示文摘 | Soto A M Fernandez M F Luizzi M F | 1997 | Environ Health Perspect1997，105，3： | 2 |
| 5 | A comparative evaluation of microalgae for the degradation of piggery wastewater under photosynthetic oxygenation显示文摘 | Ignacio de Godos Virginia A. Vargas Saúl Blanco María C. García González Roberto Soto Pedro A. García-Encina Eloy Becares Raúl Mu?oz | 2010 | Bioresource Technology2010，，14： | 2 |
| 6 | Involvement of chemokine receptors in breast cancer metastasis显示文摘 | Muller A Hmey B Soto H | | 0，，： | 2 |
| 7 | Involvement of chemokine receptors in breast cancer metastasis显示文摘 | Muller A Homey B Soto H | | 0，，6824： | 2 |
| 8 | In vovvment of ckemokine receptors in breast cancer metastasis显示文摘 | Muller A Homey B Soto H | 2001 | Nature2001，420，1： | 1 |
| 9 | Involvement of chemokine receptors in breast cancer metastasis显示文摘 | Muller A Homey B Soto H Ge N Catron D Buchanan M E | 2001 | Nature2001，410，： | 1 |
| 10 | Involvement of chemokine receptors in breast cancer metastasis显示文摘 | Muller A Homey B Soto H | 2001 | Nature2001，410，6824： | 1 |
| 11 | Involvement of chemokine receptors in breast cancer metastasis显示文摘 | Muller A Homey B Soto H | 2001 | Nature2001，410，6824： | 1 |
| 12 | Performance of phisulfo fatty methyl ester sulfonate versus linear alkylbenzene sulfonate,secondary alkane sulfonate and alpha -sulfo fatty methyl ester sulfonate显示文摘 | Cohen L Soto F Melgarejo A | 2008 | Journal of Surfactants and Detergents2008，11，： | 1 |
| 13 | Succ-essful intraoperative spinal cord monitoring during scoliosis surgery using a total intravenous anesthetic regimen including dexmedetomidine显示文摘 | ANSCHEL D J AHERNE A SOTO R G | 2008 | J Clin Neurophysiol2008，25，1： | 1 |
| 14 | MR cholangiopancreatography:techniques and clinical application显示文摘 | Baiish M A Soto J A | 1997 | AJR1997，169，12： | 1 |
| 15 | A method for calculating the magnetic field produced by a coil of any shape显示文摘 | Garcia A Carrasco J A Soto J F | 2001 | Sensors and Actuators A2001，91，12： | 1 |
| 16 | Self-optimization in tool wear for friction-stir welding of Al 6061 +20% Al2O3 MMC显示文摘 | Prado R A Murr L E Soto K F | 2003 | Mater Sci Eng A2003，349，12： | 1 |
| 17 | Involvement of chemokine receptors in breast cancer metastasis显示文摘 | Muller A Homey B Soto H | 2001 | Nature2001，410，6824： | 1 |
| 18 | Developmental effects of endocrine-disrupting chemicals in wildlife and humans显示文摘 | Colborn T Saal F S V Soto A M | 1993 | Environmental Health Perspectives1993，101，5： | 1 |
| 19 | Involvement of chemokine re?ceptors in breast cancer metastasis显示文摘 | Muller A Homey B Soto H | 2001 | Nature2001，410，6824： | 1 |
| 20 | Diagnosis of arte- rial injuries caused by penetrating trauma to the neck: comparison of helical CT angiography and conventional angiography 显示文摘 | Munera F Soto J A Palacio D | 2000 | Radiology2000，216，2： | 1 |
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