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| 1 | Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer显示文摘BACKGROUND The connection between inflammatory bowel disease(IBD)and colorectal cancer(CRC)is well-established,as persistent intestinal inflammation plays a substantial role in both disorders.Cytokines may further influence the inflammation and the carcinogenesis process.AIM To compare cytokine patterns of active IBD patients with early and advanced CRC.METHODS Choosing a panel of cytokines crucial for Th17/Treg differentiation and behavior,in colon specimens,as mRNA biomarkers,and their serum protein levels.RESULTS We found a significant difference between higher gene expression of FoxP3,TGFb1,IL-10,and IL-23,and approximately equal level of IL-6 in CRC patients in comparison with IBD patients.After stratification of CRC patients,we found a significant difference in FoxP3,IL-10,IL-23,and IL-17A mRNA in early cases compared to IBD,and IL-23 alone in advanced CRC.The protein levels of the cytokines were significantly higher in CRC patients compared to IBD patients.CONCLUSION Our findings showed that IL-6 upregulation is essential for both IBD and CRC development until the upregulation of other Th17/Treg related genes(TGFb1,IL-10,IL-23,and transcription factor FoxP3)is a crucial primarily for CRC development.The significantly upregulated IL-6 could be a potential drug target for IBD and prevention of CRC development as well. | Tsvetelina Veselinova Velikova Lyuba Miteva Noyko Stanilov Zoya Spassova Spaska Angelova Stanilova | 2020 | World Journal of Gastroenterology2020，26，16： | 10 |
| 2 | STIMI has a plasma membrane role in the activation of store-operated Ca^2+ channels 显示文摘 | Spassova MA Soboloff J He LP | 2006 | Proc Natl Aead Sci U S A2006，103，11： | 1 |
| 3 | The tomato gene Sw-5 is a member of the coiled coil,nucle- otide binding,leucine-rich repeat class of plant resistance genes and confers resistance to TSWV in tobacco 显示文摘 | Spassova M L Prins T W Folkertsma R T | 2001 | Mol Breed2001，7，2： | 1 |
| 4 | Orail and STIM reconstitute store-operated calcium channel function 显示文摘 | Soboloff J Spassova M A Tang X D | 2006 | J Biol Chem2006，281，20： | 1 |
| 5 | Orail and STIM reconstitute store-operated calcium channel function显示文摘 | Soboloff J Spassova MA Tang XD | 2006 | J Biol Chem2006，281，20： | 1 |
| 6 | STIM2 is an inhibitor of STIMl-medlated store-operated Ca2+ Entry 显示文摘 | Soboloff J Spassova MA Hewavitharana T | 2006 | Curr Biol2006，16，14： | 1 |
| 7 | STIM1 has a plasma membrane role in the activation of store-operated Ca2+ channels显示文摘 | Soboloff J He LP | 2006 | Proc Natl Acad Sci USA2006，103，： | 1 |
| 8 | Calcium signals mediated by STIM and Orai proteins-a new paradigm in inter-organelle communication 显示文摘 | Soboloff J Spassova MA Dziadek MA | 2006 | Biochim Biophys Acta2006，1763，11： | 1 |
| 9 | Orail and STIM reconsti- tute store-operated calcium channel function 显示文摘 | Soboloff J Spassova MA Tang XD | 2006 | J Biol Chem2006，281，20： | 1 |
| 10 | Primary and combined resistance to four antimicrobial agents in Helicobacter pylori in Sofia, Bugaria显示文摘 | Boyanova L Stancheva I Spassova Z | 2000 | J Med Microbiot2000，49，5： | 1 |
| 11 | Quantitative analysis of polychlorinated biphenyls,organochlorine insecticides,polycyclic aromatic hydrocarbons,polychlorinated hydrocarbons and polynitrohydrocarbons in spiked samples of soil,water and plasma by selected-ion monitoring gas chromatography-mass spectrometry显示文摘 | Singh A K Spassova D White T 1998 | 1998 | Joumal of Chromatography B1998，706，： | 1 |
| 12 | Thin polyimide layers preparation and properties显示文摘 | AssaJ Spassova A E Karamancheva AI | 1998 | Vacuum1998，51，2： | 1 |
| 13 | On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process:total synthesis and comparative in vivo evaluations of the 15-Aza Epothilones显示文摘 | Stachel S J Lee C B Spassova M | 2001 | J Org Chem2001，66，12： | 1 |
| 14 | Vacuum deposited polyimide thin films显示文摘 | Spassova E | 2003 | Vacuum2003，70，4： | 1 |
| 15 | Si (Ⅳ)-methoxyethylene-glycol-naphthalocyanine:synthesis and pharmacokinetic and photosensitizing properties in different tumour models显示文摘 | V. Mantareva M.Shopova G. Spassova | | 0，，： | 1 |
| 16 | Acute effects of acephate and methamidophos on acetylcholinesterase activity, endocrine system and amino acid concentrations in rats显示文摘 | Dina Spassova Thomas White Ashok K Singh | 1999 | Comparative Biochemistry and Physiology. Part C: Comparative Pharmacology and Toxicology1999，，1： | 1 |
| 17 | Vacuum deposited polyimide thin films 显示文摘 | SPASSOVA E | 2003 | Vacuum2003，70，： | 1 |
| 18 | Role of endogenous TRPC6 channels in Ca^2+ signal generation in A7r5 smooth muscle cells 显示文摘 | Soholoff J Spassova M Xu W | 2005 | Biol Chem2005，280，39： | 1 |
| 19 | STIMI has a plasma membrane role in the activation of store-operated Car') chan?nels显示文摘 | Spassova MA Soboloff J He LP | 2006 | Proc Natl Acad Sci USA2006，103，11： | 1 |
| 20 | Vacuum deposition polyimide---A perfect matrix for nanocomposition materials 显示文摘 | Danev G Spassova E Assa J | 2005 | J Optoelectron Adv Mater2005，7，： | 1 |
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