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| 1 | Shell Cansolv CO 2 capture technology: Achievement from First Commercial Plant显示文摘 | Ajay Singh Karl Stéphenne | 2014 | Energy Procedia2014，，： | 1 |
| 2 | A dynamic simulation model of land-use change in Sudano-sahelian countries of Africa(SALU) 显示文摘 | Stéphenne N Lambin E F | 2001 | Agric Ecosyst Environ2001，85，13： | 1 |
| 3 | Hepatocyte cryopreservation:Is it time to change the strategy?显示文摘Liver cell transplantation presents clinical benefit in patients with inborn errors of metabolism as an alternative,or at least as a bridge,to orthotopic liver transplantation.The success of such a therapeutic approach remains limited by the quality of the transplanted cells.Cryopreservation remains the best option for long-term storage of hepatocytes,providing a permanent and sufficient cell supply.However, isolated adult hepatocytes are poorly resistant to such a process,with a significant alteration both at the morphological and functional levels.Hence,the aim of the current review is to discuss the state of the art regarding widely-used hepatocyte cryopreservation protocols,as well as the assays performed to analyse the post-thawing cell quality both in vitro and in vivo. The majority of studies agree upon the poor quality and efficiency of cryopreserved/thawed hepatocytes as compared to freshly isolated hepatocytes.Intracellular ice formation or exposure to hyperosmotic solutionsremains the main phenomenon of cryopreservation process,and its effects on cell quality and cell death induction will be discussed.The increased knowledge and understanding of the cryopreservation process will lead to research strategies to improve the viability and the quality of the cell suspensions after thawing.Such strategies,such as vitrification,will be discussed with respect to their potential to significantly improve the quality of cell suspensions dedicated to liver cell-based therapies. | Xavier Stéphenne Mustapha Najimi Etienne M Sokal | 2010 | World Journal of Gastroenterology2010，16，1： | 9 |
| 4 | Sustained engraftment and tissue enzyme activity after liver cell transplantation for argininosuccinate lyase deficiency显示文摘 | Stéphenne X Najimi M Sibille C | 2006 | Gastroenterology2006，130，4： | 1 |
| 5 | Performance of time-delay estimation in the presence of room reverberation显示文摘 | CHAMPAGNE B BéDARD S STéPHENNE A | | 0，，02： | 1 |
| 6 | Regulation of hepatic EAAT-2 glutamate transporter expression in human liver cholestasis显示文摘AIM: To investigate the activity and expression of EAAT2 glutamate transporter in both in vitro and in vivo models of cholestasis. METHODS: This study was conducted on human hepatoblastoma HepG2 cell cultures, the liver of bile duct ligated rats and human specimens from cholestatic patients. EAAT2 glutamate transporter activity and expression were analyzed using a substrate uptake assay, immunofluorescence, reverse transcription-polymerase chain reaction, and immunohistochemistry, respectively. RESULTS: In HepG2 cells, cholestasis was mimicked by treating cells with the protein kinase C activator, phorbol 12-myristate 13-acetate. Under such conditions, EAAT2 transporter activity was decreased both at the level of substrate affinity and maximal transport velocity. The decreased uptake was correlated with intracellular translocation of EAAT2 molecules as demonstrated using immunofluorescence. In the liver of bile duct ligated rats, an increase in EAAT2 transporter protein expression in hepatocytes was demonstrated using immunohistochemistry. The same findings were observed in human liver specimens of cholestasis in which high levels of γ-glutamyl transpeptidase were documented in patients with biliary atresia and progressive familial intrahepatic cholestasis type 3. CONCLUSION: This study demonstrates the alteration in glutamate handling by hepatocytes in liver cholestasis and suggests a potential cross-talk between glutamatergic and bile systems. | Mustapha Najimi Xavier Stéphenne Christine Sempoux Etienne Sokal | 2014 | World Journal of Gastroenterology2014，20，6： | 0 |
| 7 | Liver cell transplantation for Crigler-Najjar syndrome type Ⅰ: Update and perspectives显示文摘Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such diseases in that the host liver is lacking one function with an otherwise normal parenchyma. The patient is at permanent risk for irreversible brain damage. The goal of liver cell transplantation is to reduce serum bilirubin levels within safe limits and to alleviate phototherapy requirements to improve quality of life. Preliminary data on Gunn rats, the rodent model of the disease, were encouraging and have led to successful clinical trials. Herein we report on two additional patients and describe the current limits of the technique in terms of durability of the response as compared to alternative therapeutic procedures. We discuss the future developments of the technique and new emerging perspectives. | Philippe A Lysy Mustapha Najimi Xavier Stéphenne Annick Bourgois Franoise Smets Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，22： | 9 |
| 8 | Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection in children and adolescents显示文摘 | Etienne M. Sokal Annick Bourgois Xavier Stéphenne Themis Silveira Gilda Porta Dace Gardovska Bj?rn Fischler Deirdre Kelly | 2010 | Journal of Hepatology2010，，6： | 1 |
| 9 | Sustained Engraftment and Tissue Enzyme Activity After Liver Cell Transplantation for Argininosuccinate Lyase Deficiency显示文摘 | Xavier Stéphenne Mustapha Najimi Catherine Sibille Marie–Cécile Nassogne Fran?oise Smets Etienne M. Sokal | 2006 | Gastroenterology2006，，4： | 1 |
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